Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 1  |  Page : 14-

Impact of admission calcium-phosphate product on 1-year mortality among hospitalized patients


Wisit Cheungpasitporn1, Charat Thongprayoon3, Panupong Hansrivijit2, Juan Medaura3, Api Chewcharat5, Tarun Bathini4, Michael A Mao5, Stephen B Erickson7 
1 Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi; Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
2 Department of Internal Medicine, University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA, USA
3 Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi, USA
4 Department of Internal Medicine, University of Arizona, Tucson, Arizona, USA
5 Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA

Correspondence Address:
Dr. Wisit Cheungpasitporn
Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, 2500 N State Street, Jackson 39216, Mississippi
USA

Background: Calcium-phosphate product is associated with mortality among patients with end-stage kidney disease on dialysis. However, clinical evidence among hospitalized patients is limited. The objective of this study was to investigate the relationship between admission calcium-phosphate product and 1-year mortality in hospitalized patients. Materials and Methods: All adult patients admitted to a tertiary referral hospital in 2009–2013 were studied. Patients who had both available serum calcium and phosphate measurement within 24 h of hospital admission were included. Admission calcium-phosphate product (calcium × phosphate) was stratified based on its distribution into six groups: <21, 21–<27, 27–<33, 33–<39, 39–<45, and ≥45 mg2/dL2. Multivariate cox proportional hazard analysis was performed to evaluate the association between admission calcium-phosphate product and 1-year mortality, using the calcium-phosphate product of 33–<39 mg2/dL2 as the reference group. Results: A total of 14,772 patients were included in this study. The mean admission calcium-phosphate product was 34.4 ± 11.3 mg2/dL2. Of these patients, 3194 (22%) died within 1 year of hospital admission. In adjusted analysis, admission calcium-phosphate product of ≥45 mg2/dL2 was significantly associated with increased 1-year mortality with hazard ratio of 1.41 (95% 95% confidence interval 1.25–1.67), whereas lower admission calcium-phosphate product was not significantly associated with 1-year mortality. Conclusion: Elevated calcium-phosphate product was significantly associated with increased 1-year mortality in hospitalized patients.


How to cite this article:
Cheungpasitporn W, Thongprayoon C, Hansrivijit P, Medaura J, Chewcharat A, Bathini T, Mao MA, Erickson SB. Impact of admission calcium-phosphate product on 1-year mortality among hospitalized patients.Adv Biomed Res 2020;9:14-14


How to cite this URL:
Cheungpasitporn W, Thongprayoon C, Hansrivijit P, Medaura J, Chewcharat A, Bathini T, Mao MA, Erickson SB. Impact of admission calcium-phosphate product on 1-year mortality among hospitalized patients. Adv Biomed Res [serial online] 2020 [cited 2020 Dec 2 ];9:14-14
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2020;volume=9;issue=1;spage=14;epage=14;aulast=Cheungpasitporn;type=0