Advanced Biomedical Research

BRIEF COMMUNICATION
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 54-

Cisplatin Alters Sodium Excretion and Renal Clearance in Rats: Gender and Drug Dose Related


Sima Jilanchi1, Ardeshir Talebi1, Mehdi Nematbakhsh2 
1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Water and Electrolytes Research Center, Isfahan University of Medical Sciences; Department of Physiology, Isfahan University of Medical Sciences; IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Correspondence Address:
Dr. Mehdi Nematbakhsh
Department of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals. Results: The serum level of blood urea nitrogen (BUN) and creatinine (Cr), and Cr-clearance, kidney tissue damage score, kidney weight, body weight change, and Na excretion was altered significantly (P < 0.05) in animals treated with continuous dose of CP (treat 2), while alteration of BUN and Cr was gender related. The kidney levels of malondialdehyde and nitrite were significantly different between male and female in two protocols of treatments. Conclusion: Renal function after CP therapy alters in rats' gender dependently, and it is related to protocol of treatment.


How to cite this article:
Jilanchi S, Talebi A, Nematbakhsh M. Cisplatin Alters Sodium Excretion and Renal Clearance in Rats: Gender and Drug Dose Related.Adv Biomed Res 2018;7:54-54


How to cite this URL:
Jilanchi S, Talebi A, Nematbakhsh M. Cisplatin Alters Sodium Excretion and Renal Clearance in Rats: Gender and Drug Dose Related. Adv Biomed Res [serial online] 2018 [cited 2020 Nov 25 ];7:54-54
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=54;epage=54;aulast=Jilanchi;type=0