Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 5  |  Issue : 1  |  Page : 23-

Vasomotor reactivity comparison in multiple sclerosis patients with white matter lesions and nonmultiple sclerosis subjects with white matter lesions in brain magnetic resonance imaging


Fariborz Khorvash1, Ali Masaeli2, Vahid Shaygannejad1, Mohammad Saadatnia1 
1 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan, Iran
2 Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Ali Masaeli
Department of Neurology, Isfahan University of Medical Sciences, Isfahan
Iran

Background: It has been recognized a close relationship between multiple sclerosis (MS) lesions and the cerebral vasculature. In this study, we observed cerebrovascular vasomotor reactivity difference between the MS patients and the non-MS migraine individuals. Materials and Methods: This prospective study was conducted on 40 patients with MS referring to Neurology Clinic of Isfahan Al-Zahra Hospital in 2012. The patients were compared with the same number of non-MS migraine individuals. Both groups had white matter lesions in brain magnetic resonance imaging. To evaluate the rate of cerebral artery vasomotor reactivity, transcranial Doppler device was used, and breath-holding index (BHI) was separately calculated for each middle cerebral artery. Main flow velocity (MFV) was determined by continuously recording of a period of 5 min of breathing the air in the room. The obtained data were analyzed using SPSS software version 18 and t-test, Chi-square and analysis of variance tests. Results: The mean values of MFV at rest was not significantly different between cases and control groups (46.21 ± 4.20 vs. 44.69 ± 4.34, P = 0.115) but difference between cases and control groups in MFV apnea was significant (59.11 ± 5.10 vs. 55.35 ± 6.03, P = 0.004). BHI in the control group was 0.79 ± 0.26 and in the case group was 0.93 ± 0.20 and these differences was found to be significant (P < 0.05). Conclusion: The mean of BHI and cerebral vasomotor reactivity in MS patients was more than the non-MS migraine individuals, although the mechanism of this process still remains unknown.


How to cite this article:
Khorvash F, Masaeli A, Shaygannejad V, Saadatnia M. Vasomotor reactivity comparison in multiple sclerosis patients with white matter lesions and nonmultiple sclerosis subjects with white matter lesions in brain magnetic resonance imaging.Adv Biomed Res 2016;5:23-23


How to cite this URL:
Khorvash F, Masaeli A, Shaygannejad V, Saadatnia M. Vasomotor reactivity comparison in multiple sclerosis patients with white matter lesions and nonmultiple sclerosis subjects with white matter lesions in brain magnetic resonance imaging. Adv Biomed Res [serial online] 2016 [cited 2020 Dec 2 ];5:23-23
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2016;volume=5;issue=1;spage=23;epage=23;aulast=Khorvash;type=0