ORIGINAL ARTICLE
Year : 2015 | Volume
: 4 | Issue : 1 | Page : 158-
Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference
Marzieh Vafapour1, Mehdi Nematbakhsh2, Ramesh Monajemi4, Safoora Mazaheri3, Ardeshir Talebi4, Nahid Talebi1, Soheyla Shirdavani3
1 Water and Electrolytes Research Center, Isfahan University of Medical Sciences; Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
2 Water and Electrolytes Research Center; Department of Physiology, Isfahan University of Medical Sciences; Isfahan-MN Institute of Basic and Applied Sciences Research, Isfahan, Iran
3 Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Water and Electrolytes Research Center; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Mehdi Nematbakhsh
Department of Physiology, Water and Electrolytes Research Center, Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
Background: The most important cause of kidney injury is renal ischemia/reperfusion injury (IRI), which is gender-related. This study was designed to investigate the protective role of Γ-aminobutyric acid (GABA (against IRI in male and female rats.
Materials and Methods: Thirty-six female and male wistar rats were assigned to six experimental groups. The IRI was induced by clamping renal vessels for 45 min then was performed reperfusion for 24 h. The group sex posed to IRI were pretreated with GABA and were compared with the control groups.
Results: Serum levels of creatinine and blood urea nitrogen, kidney weight, and kidney tissue damage score increased in the IRI alone groups, (P < 0.05), while GABA decreased these parameters in female significantly (P < 0.05), but not in male rats. Uterus weight decreased significantly in female rats treated with GABA. Testis weight did not alter in male rats. Serum level of nitrite and kidney level of malondialdehyde (MDA) had no significant change in both female and male rats. Kidney level of nitrite increased significantly in female rats experienced IRI and serum level of MDA increased significantly in males that were exposed to IRI (P < 0.05).
Conclusion: GABA could ameliorate kidney injury induced by renal IRI in a gender dependent manner.
How to cite this article:
Vafapour M, Nematbakhsh M, Monajemi R, Mazaheri S, Talebi A, Talebi N, Shirdavani S. Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference.Adv Biomed Res 2015;4:158-158
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How to cite this URL:
Vafapour M, Nematbakhsh M, Monajemi R, Mazaheri S, Talebi A, Talebi N, Shirdavani S. Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference. Adv Biomed Res [serial online] 2015 [cited 2023 Jun 6 ];4:158-158
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=158;epage=158;aulast=Vafapour;type=0 |
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