The effect of hydroalcoholic extract from the leaves of <i>Moringa peregrina</i>(Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats :Leila Safaeian, Gholamreza Asghari, Shaghayegh Haghjoo Javanmard, Arman Heidarinejad, Advanced Biomedical Research

ORIGINAL ARTICLE
Year : 2015 | Volume : 4 | Issue : 1 | Page : 101-

The effect of hydroalcoholic extract from the leaves of Moringa peregrina(Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats

Leila Safaeian¹, Gholamreza Asghari², Shaghayegh Haghjoo Javanmard³, Arman Heidarinejad¹
¹ Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
² Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
³ Department of Physiology, Applied Physiology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Leila Safaeian
Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Moringa peregrina (Forssk.) Fiori. is a tropical tree growing in southeast of Iran. All parts of this plant have nutritional uses and pharmacological activities. The present study was designed to evaluate the effect of hydroalcoholic extract from the leaves of M. peregrina in dexamethasone (Dex)-induced hypertension in rats. Materials and Methods: Male Wistar rats received Dex (30 μg/kg, subcutaneously; s.c.) or saline (as vehicle, 1 ml/kg, s.c.) for 14 days. In a prevention study, the rats received M. peregrina extract (100, 200 and 400 mg/kg, orally) for 4 days, followed by Dex for 14 days. In a reversal study, the animals received M. peregrina extract orally from day 8 to 14. The systolic blood pressure (SBP) was measured using tail-cuff method. The hydrogen peroxide (H ₂ O ₂ ) concentration and ferric reducing antioxidant power (FRAP) were assessed in plasma samples. Results: Dex significantly increased the SBP and the plasma H ₂ O ₂ and decreased the plasma FRAP value (P < 0.001). M. peregrina extract at a dose of 400 mg/kg prevented (P < 0.01) but did not reverse Dex-induced hypertension in rats. It also dose-dependently reduced the plasma H ₂ O ₂ concentration and improved the FRAP value upon Dex administration. Conclusions: The findings of the present study indicated the antioxidant and partially antihypertensive effects of the hydroalcoholic extract from the leaves of M. peregrina in Dex-induced hypertension. Further experiments on other fractions of the leaves and also other parts of this plant are suggested for better evaluation of its antihypertensive effect and finding its mechanisms of action.

How to cite this article:
Safaeian L, Asghari G, Javanmard SH, Heidarinejad A. The effect of hydroalcoholic extract from the leaves of Moringa peregrina(Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats.Adv Biomed Res 2015;4:101-101

How to cite this URL:
Safaeian L, Asghari G, Javanmard SH, Heidarinejad A. The effect of hydroalcoholic extract from the leaves of Moringa peregrina(Forssk.) Fiori. on blood pressure and oxidative status in dexamethasone-induced hypertensive rats. Adv Biomed Res [serial online] 2015 [cited 2023 May 31 ];4:101-101
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=101;epage=101;aulast=Safaeian;type=0