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Brief Report:
The Prevalence of Osmophobia in Migranous and Episodic Tension Type Headaches
Ahmad Chitsaz, Abbas Ghorbani, Masoumeh Dashti, Mohsen Khosravi, Mohammadreza Kianmehr
Adv Biomed Res
2017, 6:44 (17 April 2017)
DOI
:10.4103/2277-9175.204587
PMID
:28503499
Background:
Migraines are a neurological disease, of which the most common symptom is an intense and disabling episodic headache. Many persons experience sensory hyper excitability manifested by photophobia, phonophobia and osmophobia. This study was planned to investigate the prevalence of osmophobia in migranous and episodic tension type headache (ETTH).
Materials and Methods:
A semi-structured questionnaire was administered to all patients to evaluate the eventual presence of osmophobia during a headache attack and different characteristics of osmophobia were determined.
Results:
Osmophobia reported in 84% with migranous headache with aura, 74% of migranous patients without aura and in 43.3% of those with ETTH.
In 50% of patients, osmophobia was present in all of their headache attacks, 11.7% had osmophobia in more than half of their attacks (from 10 attacks they reported osmophobia in 5-9 ones) and others had this sign in less than half of their attacks (from 10 attacks they reported osmophobia in less than 5 ones). Most frequently the offending odors were scents (88%), foods (54.2%) and cigarette smoke (62.5%). Osmophobia starts 30 min before the headache starts in 22.7% of patients.
Conclusion:
Osmophobia appears structurally integrated into the migraine history of the patient; however, for differential diagnosis with ETTH, other criteria are necessary.
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Brief Report:
Evaluation of Energy Balance on Human Telomerase Reverse Transcriptase (hTERT) Alternative Splicing by Semi-quantitative RT-PCR in Human Umbilical Vein Endothelial Cells
Mohaddeseh Behjati, Mohammad Hashemi, Mohammad Kazemi, Mansoor Salehi, Shaghayegh Haghjooy Javanmard
Adv Biomed Res
2017, 6:43 (17 April 2017)
DOI
:10.4103/2277-9175.204591
PMID
:28503498
Background:
Decreased high-energy phosphate level is involved in endothelial cell injury and dysfunction. Reduced telomerase activity in endothelial cells in parallel with reduced energy levels might be due to altered direction of alternative splicing machine as a complication of depleted energy during the process of atherosclerosis.
Materials and Methods:
Isolated human umbilical vein endothelial cells (HUVECs) were treated for 24 hours by oligomycine (OM) and 2-deoxy glucose (2-DG). After 24 hours, the effect of energy depletion on telomerase splicing pattern was evaluated using RT-PCR. Indeed, in both treated and untargeted cells, nitric oxide (NO) and von Willebrand factor (vWF) were measured.
Results:
ATP was depleted in treated cells by 43.9% compared with control group. We observed a slight decrease in NO levels (
P
= 0.09) and vWF (
P
= 0.395) in the setting of 49.36% ATP depletion. In both groups, no telomerase gene expression was seen. Telomerase and housekeeping gene expression were found in positive control group (colon cancer tissue) and sample tissue.
Conclusions:
The absence of telomerase gene expression in HUVECs might be due to the mortality of these cells or the low level of telomerase gene expression in these cells under normal circumstances.
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1
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1
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2019
March
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1
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February
[
1
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January
[
1
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2018
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1
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December
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1
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3
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2
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July
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1
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May
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1
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April
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2
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March
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1
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January
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1
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December
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3
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July
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1
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May
[
2
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April
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1
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March
[
4
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4
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1
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1
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1
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3
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September
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1
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May
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1
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January
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2
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2013
October
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1
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2012
October
[
1
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