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Original Article:
Hydroalcoholic tarooneh extract (Spathe of Phoenix Dactylifera) increased sedative-hypnotic effects and modulated electroencephalography brain waves in anesthetized rats
Sahar Rahimi, Hojjatollah Alaei, Parham Reisi, Bahare Zarrin, Zahra Siahmard, Ali Asghar Pourshanazari
Adv Biomed Res
2019, 8:24 (28 March 2019)
DOI
:10.4103/2277-9175.255135
PMID
:31008090
Background:
Spathe of phoenix dactylifera is hard-covering envelope of date palm which is mentioned as a nerve relief in ancient medicine books. In this experiment, three extract doses used in sleeping time, sedative efficacy, and electroencephalography (EEG) protocol to show different aspects of extract effects on sleep.
Materials and Methods:
In three sleeping time, anesthesia time and EEG experiment protocols test group containing three extract doses (62.5, 125, and 250 mg/kg) were compared with saline control group, and in sleeping time experiment control group contained intact, midazolam, and saline group to detail more in behavioral Angel method.
Results:
Three extract doses increased sleeping time when compared with saline control group (
P
< 0.05). In evaluated sedative efficacy, two 125 and 250 mg/kg doses increased anesthesia and showed sedative effect (
P
< 0.05). In EEG experiment, dose 125 mg/kg increased delta waves and decreased high-frequency waves of alpha and beta. In addition, there were significant decreases in alpha waves of 62.5 and 250 mg/kg doses.
Conclusion:
Although all three doses increased sleeping time, dose 125 mg/kg is more efficient for deep and relaxing sleep and suits more for related researches.
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Original Article:
In vitro
Antibacterial Effect of Hydroalcoholic Extract of
Lawsonia inermis, Malva sylvestris
, and
Boswellia serrata
on
Aggregatibacter actinomycetemcomitans
Surena Vahabi, Mojdeh Hakemi-Vala, Samaneh Gholami
Adv Biomed Res
2019, 8:22 (20 March 2019)
DOI
:10.4103/2277-9175.254625
PMID
:31016180
Background:
Considering the increased rate of microbial resistance to antibiotics and chemical side effects of antibiotics and antiseptics used for the treatment of periodontal disease, there is a need for an alternative antimicrobial agent with fewer complications. Medicinal herbs have recently become popular as novel antimicrobial agents. This study aimed to assess the antibacterial effects of hydroalcoholic extracts of
Lawsonia inermis, Malva sylvestris
, and
Boswellia serrata
on
Aggregatibacter actinomycetemcomitans
.
Materials and Methods:
Hydroalcoholic extracts of the three medicinal plants were obtained by the maceration technique and
A. actinomycetemcomitans
was cultured. Antimicrobial efficacy of the three medicinal plants was compared with that of 0.2% chlorhexidine (CHX) according to the Clinical and Laboratory Standards Institute protocol using agar disc diffusion and broth microdilution techniques. All tests were repeated three times.
Results:
Hydroalcoholic extracts of all three plants had antimicrobial activity against
A. actinomycetemcomitans
. The minimum inhibitory concentration (MIC) of
L. inermis, M. sylvestris
, and
B. serrata
was 78.1, 156.2, and 1666 μg/mL with no significant difference between them. The MIC of CHX was 3.33 μg/mL, which was significantly higher than that of
B. serrata
extract.
Conclusion:
Given that further
in vivo
studies confirm other properties of these extracts and their safety in terms of cytotoxicity and mutagenicity, hydroalcoholic extracts of
L. inermis
and
M. sylvestris
may be used in mouthwashes or local delivery systems to affect periodontal biofilm.
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Original Article:
Diagnostic Value of Cytology in Detecting Endometrial Hyperplasia and Endometrial and Ovarian Cancers in Patients Undergoing Hysterectomy or Salpingo-Oophorectomy
Tajossadat Allameh, Shiva Danesh-Pour, Nooshin Afshar Moghadam, Shima Danesh-Pour
Adv Biomed Res
2019, 8:20 (20 March 2019)
DOI
:10.4103/2277-9175.254623
PMID
:31016178
Background:
Ovarian cancer (OC) is one of the most common cancers among women in the world. This study aimed to compare the results of endometrial and endocervical cytology with the ultimate outcome of the uterus, ovary, and fallopian tube (derived from hysterectomy or salpingo-oophorectomy) in diagnosing endometrial hyperplasia, endometrial, and OC.
Materials and Methods:
This cross-sectional study was conducted on 30 women with endometrial hyperplasia, 90 cases of endometrial cancer, 30 cases of OC, and 30 normal controls undergoing hysterectomy or salpingo-oophorectomy referring to Al-Zahra and Shahid Beheshti Hospitals in 2015–2017. Their basic and clinical characteristics were recorded, and then, endometrial cytology was performed by a specialist and sent to a pathological center.
Results:
Diagnostic value of cytology showed that out of 90 individuals with endometrial cancer, 78 (86.7%) ones were positive and 12 (13.3%) were negative with sensitivity and specificity of 86.67% and 100%, respectively. Its positive predictive values (PPVs) and negative predictive values (NPVs) were 100% and 71.4% (AUC = 0.933;
P
< 0.0001). In diagnosing endometrial hyperplasia out of 30 individuals with endometrial hyperplasia, there were 24 (80.0%) positive and 6 (20.0%) negative with sensitivity and specificity of 80.00% and 100%, respectively. Its PPVs and NPVs were 100% and 83.3%, respectively (AUC = 0.9000;
P
< 0.0001). In diagnosing, OC cytology could not detect any one of the 30 individuals with OC, with sensitivity and specificity of 0% and 100.0%, respectively. Its PPVs and NPVs were 0% and 50%, respectively (AUC = 0.500;
P
= 1.00).
Conclusion:
Cytology has a good diagnostic value for detecting endometrial hyperplasia and endometrial cancer compared to pathology; however, due to very low sensitivity in detection of OC, it could not be considered as a good diagnostic tool.
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Month wise articles
Figures next to the month indicate the number of articles in that month
2021
February
[
3
]
January
[
6
]
2020
December
[
6
]
November
[
5
]
October
[
12
]
September
[
8
]
August
[
5
]
July
[
6
]
June
[
1
]
May
[
5
]
April
[
5
]
March
[
2
]
February
[
3
]
January
[
5
]
2019
December
[
2
]
November
[
4
]
October
[
4
]
September
[
4
]
August
[
5
]
July
[
3
]
June
[
7
]
May
[
3
]
April
[
4
]
March
[
3
]
February
[
6
]
2018
December
[
1
]
November
[
8
]
October
[
7
]
September
[
2
]
August
[
9
]
July
[
7
]
June
[
9
]
May
[
12
]
April
[
15
]
March
[
13
]
February
[
14
]
January
[
19
]
2017
December
[
8
]
November
[
16
]
October
[
9
]
September
[
8
]
August
[
13
]
July
[
17
]
June
[
10
]
May
[
9
]
April
[
9
]
March
[
16
]
February
[
7
]
January
[
6
]
2016
December
[
10
]
November
[
18
]
October
[
10
]
September
[
9
]
August
[
19
]
July
[
14
]
June
[
16
]
May
[
14
]
April
[
10
]
March
[
27
]
February
[
14
]
January
[
13
]
2015
December
[
2
]
November
[
14
]
October
[
24
]
September
[
27
]
August
[
8
]
July
[
26
]
June
[
9
]
May
[
35
]
March
[
11
]
February
[
19
]
January
[
29
]
2014
December
[
14
]
November
[
21
]
October
[
18
]
September
[
16
]
August
[
21
]
July
[
12
]
June
[
8
]
May
[
17
]
April
[
2
]
March
[
15
]
February
[
10
]
January
[
56
]
2013
November
[
8
]
October
[
4
]
July
[
18
]
June
[
8
]
March
[
32
]
2012
December
[
4
]
October
[
14
]
August
[
29
]
July
[
10
]
May
[
7
]
March
[
7
]
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Online since 15 January, 2012