Users Online: 1441
Home
About us
Editorial board
Search
Browse articles
Submit article
Ahead of Print
Instructions
Subscribe
Contacts
Login
» Articles published in the past year
To view other articles click corresponding year from the navigation links on the side bar.
All
|
Brief Communication
|
Brief Reports
|
Case Report and Literature Review
|
Case Reports
|
Editorial
|
Erratum
|
Letter to Editor
|
Letters to Editor
|
Notice of Retraction
|
Original Article
|
Original Articles
|
Research Articles
|
Review Articles
|
Review Report
|
Short Communications
|
Systematic Review
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Show all abstracts
Show selected abstracts
Export selected to
Add to my list
Brief Report:
Knowledge, attitude, and performance of medical staff of teaching healthcare settings about hepatitis B and C in Isfahan, Iran
Behrooz Ataei, Mohsen Meidani, Maryam Khosravi, Farzin Khorvash, Mojtaba Akbari
Adv Biomed Res
2014, 3:267 (31 December 2014)
DOI
:10.4103/2277-9175.148249
PMID
:25625106
Background:
hospital personnel are at high risk of exposure, infection, and transmission of viral hepatitis. The present study aimed at investigating the knowledge, attitude, and performance of health service providers to provide them with the information required for their educational promotion on viral hepatitis.
Materials and Methods:
This cross-sectional study was conducted on 400 staff of the forenamed healthcare settings such as on nurses, midwives, licensed practical nurses, and lab officials in Isfahan, Iran, in 2012. A checklist including demographic data and questions associated with the knowledge (18 questions), attitude (4 questions), and performance (15 questions) on hepatitis B and C was completed by the participants.
Results:
A total of 388 participants completed the checklist. Participants' knowledge on the ways of transmission, prevalence, vaccination, and prevention methods was moderate (total score = 58.56 ± 10.1 percent) and the attitude was generally positive. Proper vaccination was carried out by 81.4% of the participants. Accidental injury by a needle was reported in 47.7% of the participants, but only 37.6% of them reported it to higher authorities and of them only 13.7% received appropriate treatment. Only 44.3% and 11.6% of participants reported always using gloves and masks, respectively, and 58.8% of the staff covered the needle cap before transferring it to the safety box.
Conclusions:
Due to excessive contact with patients, a paramedic-educated society is expected to have an optimal level of knowledge, attitude, and performance related to viral hepatitis. Our results from the checklists showed that medical personnel are not appropriately aware of viral hepatitis and their performance, too, is not satisfactory. Further continuous training is required and there needs to be more emphasis on actions regarding behaviors with high risk of infection transmission.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (4) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Review Article:
Mesenchymal stem cells derived in vitro transdifferentiated insulin-producing cells: A new approach to treat type 1 diabetes
Shruti Dave
Adv Biomed Res
2014, 3:266 (31 December 2014)
DOI
:10.4103/2277-9175.148247
PMID
:25625105
The pathophysiology of type 1 diabetes mellitus (T1DM) is largely related to an innate defect in the immune system culminating in a loss of self-tolerance and destruction of the insulin-producing β-cells. Currently, there is no definitive cure for T1DM. Insulin injection does not mimic the precise regulation of β-cells on glucose homeostasis, leading long term to the development of complications. Stem cell therapy is a promising approach and specifically mesenchymal stem cells (MSCs) offer a promising possibility that deserves to be explored further. MSCs are multipotent, nonhematopoietic progenitors. They have been explored as an treatment option in tissue regeneration as well as potential of
in vitro
transdifferentiation into insulin-secreting cells. Thus, the major therapeutic goals for T1DM have been achieved in this way. The regenerative capabilities of MSCs have been a driving force to initiate studies testing their therapeutic effectiveness; their immunomodulatory properties have been equally exciting; which would appear capable of disabling immune dysregulation that leads to β-cell destruction in T1DM. Furthermore, MSCs can be cultured under specially defined conditions, their transdifferentiation can be directed toward the β-cell phenotype, and the formation of insulin-producing cells (IPCs) can be targeted. To date, the role of MSCs-derived IPC in T1DM-a unique approach with some positive findings-have been unexplored, but it is still in its very early phase. In this study, a new approach of MSCs-derived IPCs, as a potential therapeutic benefit for T1DM in experimental animal models as well as in humans has been summarized.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (14) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Brief Report:
Resectability of the pancreatic adenocarcinoma: A study from Iran
Mahmud Baghbanian, Hasan Salmanroghani, Ali Baghbanian, Mohsen Bakhtpour, Bijan Shabazkhani
Adv Biomed Res
2014, 3:265 (31 December 2014)
DOI
:10.4103/2277-9175.148246
PMID
:25625104
Background:
Definite treatment of pancreatic adenocarcinoma is surgical resection. Absence of early symptoms in most patients leads to late diagnosis and treatment. This study aims to evaluate resectability of the pancreatic adenocarcinoma at the time of the diagnosis in Iran.
Materials and Methods:
The present study which is of a descriptive, prospective and case series nature, has been studying the resectability of the pancreatic adenocarcinoma by multi-detector computerized tomography, endoscopic ultrasonography, laparoscopy and/or laparotomy in 157 patients for the duration of 2 years since November 2009.
Results:
A total of 157 patients were enrolled in this study. Majority of them (68%) were male. The mean age was 67 years. Final diagnosis obtained 1-12 (2.7 ± 1.6) months after beginning of the symptoms. The lesion situated in the head of the pancreas in 127 cases (81%). Vascular invasion, lymphadenopathy, liver metastasis and peritoneal involvement were seen in 88%, 57%, 43% and 19% of the patients, respectively. According to imaging, tumor was resectable in 10 (6%) patients but laparoscopy and/or laparotomy revealed that only five cases (3%) were actually resectable. After 24 months, only 8 patients were alive; 5 cases of them had been treated by Whipple surgery and other 3 cases were under the chemotherapy. At 1 and 2 year survival rate of the patients was 11% and 5%, respectively.
Conclusion:
Majority (97%) of the pancreatic adenocarcinomas are unresectable at the time of diagnosis. Thus, meticulous preoperative assessment of patients is essential in patients to avoid major surgery in unresectable cases.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Case Report:
Erythema nodosum migrans successfully treated with indomethacin: A rare entity
Fatemeh Mokhtari, Bahareh Abtahi-Naeini, Mohsen Pourazizi
Adv Biomed Res
2014, 3:264 (31 December 2014)
DOI
:10.4103/2277-9175.148243
PMID
:25625103
Erythema nodosum migrans (subacute nodular migratory panniculitis) is a panniculitis characterized by migrating subcutaneous nodules or plaque on the lower extremity. We describe a 75-year-old woman with idiopathic erythema nodosum migrans which was manifest centrifugally spreading, slightly morpheaform erythematous plaque on the lower left leg successfully treated with indomethacin. She was initially diagnosed and treated as a case with cellulitis and with poor clinical response. A biopsy specimen from this lesion showed that the septal was thickening; fibrous tissue was also seen with lymphohistiocytic infiltrate and occasional multinucleated giant cells with some inflammatory cells infiltrated into the periphery of the fat lobules. Erythema nodosum migrans should be kept in mind in the differential diagnosis of any morpheaform centrifugally expended plaque, especially in the lower extremities in cases of unknown etiology.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Case Report:
Creeping eruption of the hand in an Iranian patient: Cutaneous larva migrans
Zabihollah Shahmoradi, Bahareh Abtahi-Naeini, Mohsen Pourazizi, Mohsen Meidani
Adv Biomed Res
2014, 3:263 (31 December 2014)
DOI
:10.4103/2277-9175.148239
PMID
:25625102
Cutaneous larva migrans (CLM), a serpiginous cutaneous eruption is the most commonly acquired tropical dermatosis. It is caused by infection with hookworm larvae in tropical and sub-tropical areas, and people who have a history of travel in these countries. The most frequent location of CLM is the distal lower extremities or buttocks. We describe a case of 57-year-old Iranian female patient with CLM of hand (unusual site) without traveling to endemic countries that was successfully treated with oral albendazole. To the best of our knowledge, this is the first report of CLM in Iran.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
The efficacy of oral isotretinoin versus cyproterone compound in female patients with acne and the triad of cutaneous hyperandrogenism: A randomized clinical trial
Gita Faghihi, Kioumars Jamshidi, Nabet Tajmirriahi, Bahareh Abtahi-Naeini, Mohamadali Nilforoshzadeh, Mohamadreza Radan, Sayed Mohsen Hosseini
Adv Biomed Res
2014, 3:262 (31 December 2014)
DOI
:10.4103/2277-9175.148236
PMID
:25625101
Background:
SAHA (Seborrhea, Acne, Hirsutism and Androgenetic Alopecia) syndrome is a dermatologic disorder, with variant response to treatment. Triad of cutaneous hyperandrogenism included nodulocystic or severe acne, female pattern hair loss and hirsutism.
Aim:
The aim of this study is to compare the effectiveness of isotretinoin and cyproterone compound in the treatment of nodulocystic acne, in patients with SAHA syndrome or triad of cutaneous hyperandrogenism.
Materials and Methods:
30 female patients with SAHA syndrome were divided randomly into two groups. Group A was treated with cyproterone compound from day 5 of menstrual cycle onwards for 3 weeks and a week without it and group B received isotretinoin, with a dose of 0.75 mg/kg per day from the beginning of menses onwards for 4 months. The results were evaluated by a blind dermatologist using Acne Severity Index (ASI) score at baseline and monthly for 4 months.
Results:
Despite a continuous reduction in ASI score in both the groups, according to both physician (
P
= 0.63) and patient (
P
= 0.25) assessment, cyproterone compound was not statistically more effective than conventional treatment of nodulocystic acne at the end of the study. Side-effects were reported in patients in both groups, generally being mild and tolerable except in two subjects.
Conclusion:
This study indicates that cyproterone compound is not superior to isotretinoin in the treatment of nodulocystic acne in patient with SAHA syndrome or triad of cutaneous hyperandrogenism. Indeed, other studies are needed to evaluate the effect of cyproterone compound (regardless of androgen level) and isotretinoin in subjects with only nodulocystic acne.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide
Shiva Seirafian, Yalda Haghdarsaheli, Mojgan Mortazavi, Mohsen Hosseini, Firouzeh Moeinzadeh
Adv Biomed Res
2014, 3:261 (31 December 2014)
DOI
:10.4103/2277-9175.148234
PMID
:25625100
Background:
The risk of cardiovascular disease in dialysis patients is higher than the general population. Vitamin D receptors exist in myocardium inhibit cardiac hypertrophy. N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a neurohormone secreted by the heart in response to ventricular mass increase. This study aimed to evaluate the effect of oral vitamin D on serum level of pro-B-type natriuretic peptide (pro-BNP) in peritoneal dialysis patients.
Materials
and
Methods:
In a randomized clinical trial, 84 peritoneal dialysis patients (49 males and 35 females) were randomly divided into two groups. The intervention group received 50000 units oral vitamin D per week, for 12 weeks if 25-hydroxy-vitamin D level was <10 ng/ml and for 8 weeks if it was between 10 ng/ml and 30 ng/ml. The control group received placebo. Parathyroid hormone, calcium, phosphor, 25-hydroxy-vitamin D, albumin and NT-pro-BNP were evaluated before and after the study.
Results:
The mean serum level of pro-BNP in patients receiving vitamin D and placebo group before the study was 875 pg/ml and 793 pg/ml, respectively. There was 895.9 pg/ml in the intervention group and 736.7 pg/ml in the control group (
P
= 0.7). Mean serum level of 25(OH) D in patients receiving oral vitamin D and placebo group before the study was 16.9 ng/ml and 31.9 ng/ml, respectively. There was 28.9 ng/ml in the intervention group and 12.9 ng/ml in the control group (
P
= 0.001). There were no significant differences regarding other indices (Alb, P, Ca, intact parathyroid hormone) between two groups.
Conclusion:
Vitamin D did not significantly change the serum level of pro-BNP in peritoneal dialysis patients.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (3) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Aminoguanidine partially prevents the reduction in liver pyruvate kinase activity in diabetic rats
Alimohammad Amiri Majd, Mohammad Taghi Goodarzi, Taghi Hassanzadeh, Heidar Tavilani, Jamshid Karimi
Adv Biomed Res
2014, 3:260 (31 December 2014)
DOI
:10.4103/2277-9175.148233
PMID
:25625099
Background
: Low molecular weight aldehydes and carbonyl compounds which are derived from glucose metabolism are prevalent in diabetic plasma. These compounds react to amino groups of Lys and Arg and lead to the formation of advanced glycation end products (AGEs). This modification changes the function of the proteins. The present study aimed to survey the effect of diabetes on rat liver pyruvate kinase activity and to show the inhibitory effect of aminoguanidine (AG).
Materials and Methods
: Male Wistar rats (
n
= 18, 6 to 8 weeks old) were divided randomly in three groups: the first group as control; second and third groups were induced diabetes using streptozocin. Third group received AG orally for 8 weeks after diabetes induction. Liver cell homogenate was prepared from all studied groups and L-type pyruvate kinase was separated from the homogenate. Pyruvate kinase activity was determined in both liver cell homogenate and extracted L-type PK. The PK activity was compared in all samples between groups.
Results
: PK activity in isolated form and in liver cell homogenate was lower in diabetic rats as compared to control group. AG-treated group showed higher PK activity compared to untreated diabetic group; however, the difference was not significant. Non-significant difference in PK activity between AG-treated diabetic and non-diabetic (control) group indicated the inhibitory effect of AG in glycation of PK.
Conclusion
: The obtained results showed PK activity decreased in diabetic rats and AG can partially prevent the reduction in PK activity.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Comparison the efficacy of ablative CO
2
laser and fractional CO
2
laser on the healing of cutaneous leishmaniasis scars
Mohammad Ali Nilforoushzadeh, Shahriar Minaravesh, Fariba Jaffary, Amir Hossein Siadat, Elaheh Haftbaradaran
Adv Biomed Res
2014, 3:259 (31 December 2014)
DOI
:10.4103/2277-9175.148231
PMID
:25625098
Background:
The aim of this study is to compare ablative CO
2
laser with fractional CO
2
laser on healing of the wound and the size of cutaneous leishmaniasis scars.
Materials and Methods:
This prospective randomized clinical trial study was done on 120 patients in two groups evaluated in Sedigheh Tahereh Hospital in Isfahan. The patients in case group underwent one session ablative CO
2
laser for treatment of leishmaniasis scars and the patients in control group underwent si x 3-weeks interval sessions fractional CO
2
laser for treatment of leishmaniasis scars. All cases were evaluated from size and other aspects of scar by a questionnaire, and before and 6 months after photos were evaluated by blinded dermatologist. The data collected in the check list was then analyzed by
t
-test and Chi-square with SPSS 20.
Results:
There were 60 people in case group and 60 in control group. The mean age was 27.21 ± 11.2. Our results show that fractional CO
2
laser is better than ablative CO
2
laser in various aspect of treatment of leishmaniasis scars (
P
< 0.05).
Conclusions:
Fractional CO
2
laser is better than ablative CO
2
laser in variants aspect of treatment of leishmaniasis scars.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
The effect of pulp and seed extract of Citrullus Colocynthis, as an antidaibetic medicinal herb, on hepatocytes glycogen stores in diabetic rabbits
Hajar Shafaei, Jafar Soleimani Rad, Abbas Delazar, Mohaddeseh Behjati
Adv Biomed Res
2014, 3:258 (31 December 2014)
DOI
:10.4103/2277-9175.148230
PMID
:25625097
Background
: Medicinal herbs such as Citrullus Colocynthis (C.C) have been used traditionally in the treatment of diabetes mellitus. However therapeutic applications and adverse effects of C.C and its natural variants are not determined well. The current work investigates the effects of pulp and seed extract of C.C on hepatocyte's glycogen stores.
Materials and Methods
: Thirty six male rabbits were divided into six groups (control and diabetic) randomly. Alloxan was used in order to induce diabetes mellitus in animals. Among 5 diabetic groups, one remained as control and the rest received 100 and 200 mg/kg/day of either pulp or seed extract. One month later, animals were sacrificed and their liver specimen fixed in 10% Formalin was stained with periodic acid schiff (PAS) for light microscopic scanning.
Results
: PAS staining of hepatocytes revealed large amounts of glycogen stores in diabetic animals treated with pulp and seed extracts of C.C, contrary with non-treated diabetic rabbits. Sites of glycogen deposition were also different in animals treated with seed extract (
P
< 0.0001). No hepatic congestion was seen in treated animals. Dose escalation has no effect on the obtained results.
Conclusions
: The anti-diabetic effects of C.C can be explained by its effects on accumulation of glycogen stores in hepatocytes. The importance of varied sites of glycogen deposition by the application of C.C needs to be determined.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (4) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Comparison of the effects of two different formulas of fluids in craniotomy patients
Mohammadali Attari, Shahryar Sane, Akbar Bordbar
Adv Biomed Res
2014, 3:257 (12 December 2014)
DOI
:10.4103/2277-9175.146927
PMID
:25590035
Background:
Intraoperative fluid management of the patients who had undergone neurosurgery presents special challenges for the anesthesiologist. In this study, we aimed to compare the effects of two fluid combinations (half-normal + bicarbonate with saline + Ringer's lactate) on brain relaxation, and acid, base, and hemodynamic balance in patients undergoing elective craniotomy surgery.
Materials and Methods:
This randomized double-blind controlled clinical trial study was done on 50 patients, of age 20-60 years, undergoing craniotomy in Alzahra Hospital in 2012. They were divided in two groups of 25 patients each. In the control group, after the patients received hypertonic saline, normal saline serum and Ringer's lactate was administered, and in the half-normal study group, 80 ml of sodium bicarbonate for every liter of it was added. Arterial blood gas (ABG) was taken before the last suture. Brain relaxation before dura opening was registered.
Results:
There was no significant difference in heart rate changes (
P
= 0.054). No significant difference was observed in the mean arterial pressure between the two groups (
P
= 0.99). Changes in pH, HCO3, and BE were not significantly different (
P
= 0.99) between the two groups. Urine output in half-normal saline group was significantly higher than in normal saline group. The mean bleeding volume was higher in normal saline group, but was not significantly different (
P
= 0.54). The mean volume of injected blood was higher in half-normal group with a significant difference (
P
= 0.54). The injected blood volume mean in half-normal group was higher with no significant difference (
P
= 0.55). The mean of brain relaxation was not different (
P
= 0.5).
Conclusion:
These two fluids did not show any significant differences in the studied variables in this research.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
[Sword Plugin for Repository]
Beta
Brief Report:
Comparison of Bristow procedure and Bankart arthroscopic method as the treatment of recurrent shoulder instability
Abolghasem Zarezade, Mohammad Dehghani, Ali Reza Rozati, Hossein Saeid Banadaki, Neda Shekarchizade
Adv Biomed Res
2014, 3:256 (12 December 2014)
DOI
:10.4103/2277-9175.146926
PMID
:25590034
Background:
Anterior shoulder dislocation is the most common major joint dislocation. In patients with recurrent shoulder dislocation, surgical intervention is necessary. In this study, two methods of treatment, Bankart arthroscopic method and open Bristow procedure, were compared.
Materials and Methods:
This clinical trial survey had been done in the orthopedic department of Alzahra and Kashani hospitals of Isfahan during 2008-2011. Patients with recurrent anterior shoulder dislocation who were candidates for surgical treatment were randomly divided into two groups, one treated by Bankart arthroscopic technique and the other treated by Bristow method. All the patients were assessed after the surgery using the criteria of ROWE, CONSTANT, UCLA, and ASES. Data were analyzed by SPSS software.
Results:
Six patients (16.22%) had inappropriate condition with ROWE score (score less than 75); of them, one had been treated with Bristow and five with Bankart (5.26 vs. 27.78). Nine patients (24.32%) had appropriate condition, which included six from Bristow group and three treated by Bankart technique (31.58 vs. 16.67). Finally, 22 patients (59.46%) showed great improvement with this score, which included 12 from Bristow and 10 from Bankart groups (63.16 vs. 55.56). According to Fisher's exact test, there were no significant differences between the two groups (
P
= 0.15).
Conclusion:
The two mentioned techniques did not differ significantly, although some parameters such as level of performance, pain intensity, use of analgesics, and range of internal rotation showed more improvement in Bristow procedure. Therefore, if there is no contraindication for Bristow procedure, it is preferred to use this method.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Case Report:
Case report on the administration of an eighty milligram diazepam injection without respiratory depression
Morteza Abdar Esfahani, Arash Beiki, Sedigheh Asgarian
Adv Biomed Res
2014, 3:255 (12 December 2014)
DOI
:10.4103/2277-9175.146925
PMID
:25590033
Nowadays one of the most challenging problems in Medicine is addiction - addiction to sedative drugs such as benzodiazepines. In this article, we are going to describe a case of diazepam addiction that has tolerated a high dose of intravenous diazepam.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Perspective on the hospital incidence rate of deep venous coagulopathy: Clinical and biochemical diagnostic markers
Alireza Khosravi, Mojgan Gharipour, Morteza Abdar Isfahani, Hamid Mohajeri, Mohammad Saadatnia, Farshad Roghani, Shahin Shirani, Arsalan Khaledifar
Adv Biomed Res
2014, 3:254 (12 December 2014)
DOI
:10.4103/2277-9175.146924
PMID
:25590032
Background:
Identifying factors contributing to the increased risk of deep venous thrombosis (DVT) in each population is vital, because of its life-threatening outcome. The current study aims to find the diagnostic performance of some laboratory coagulation markers for predicting DVT in an Iranian population complaining of DVT in the lower limbs.
Patients and Methods:
For this study, 66 consecutive patients with documented DVT, admitted to the Al-Zahra Hospital in Isfahan for the first time, were considered as the case group and 33 patients without DVT documentations were included as the control group. DVT was considered when there was visualization of thrombus or non-compressibility of the vein, confirmed by bilateral lower extremity compression Doppler ultrasonographic examination. Homocysteine, antiphospholipid, and anticardiolipin antibodies were measured in both groups by using sensitive ELISA kits. Protein C was measured via a functional clotting method, and prothrombin was measured by a kinetic, enzymatic assay.
Results:
Multivariable analysis showed that the serum homocysteine levels was potentially associated with the presence of DVT after adjusting for age and gender (OR: 1.038, 95% CI: 1.007-1.070,
P
= 0.017). Comparison of the C statistic showed a partially good discrimination of homocysteine for DVT, with the area under the receiver operating characteristic (ROC) curve being 0.614 and with the optimal cut-off value of 16.5 micromol/L (mmol/L) for men and 14.5 mmol/L for women.
Conclusion:
Hyperhomocysteinemia could be considered as an independent risk factor for DVT, with an actual acceptable prognostic value, in the Iran population.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Comparing the treatment results of proximal humerus fracture based on surgical or nonsurgical methods
Mohammad Hadi Nouraei, Davoud Amirian Majd, Fereshteh Zamani
Adv Biomed Res
2014, 3:253 (6 December 2014)
DOI
:10.4103/2277-9175.146385
PMID
:25590031
Background:
A common type of Humerus fractures is about proximal. This study aimed to compare the results of surgical and non-surgical methods in treatment the Fracture of Proximal Humerus for decisions based on high-performance and less side effect.
Materials and Methods
: This prospective clinical trial study was done on 114 patients 30-80 years old with proximal humerus fracture referred to the Isfahan hospital universities (Ayatollah Kashani and Al Zahra hospitals) in 2007-2012. They were divided into two groups of 57 and treated surgically or non-surgically. The self provided questionnaires were used to assess the consequences of the side effects. The patients returned for trial check up during 6 weeks, 3 months, 6 months and one year after intervention.
Result:
In two parts fracture with displacement, nonsurgical treatment had lead to more complications rather than surgical treatment. In three-parts fracture non-union was seen in nonsurgical method in 6 weeks and in surgical method in 3, 6 months and one year after treatment, malunion was seen more in nonsurgical method rather than surgical method. In four-part fracture none-union results was seen more in nonsurgical method in 6 weeks, 3 months and one year and in surgical method in 6 months after treatment, mal union was seen more in nonsurgical method rather than surgical method.
Conclusion:
The surgery in three and four parts fractures had fewer complications in the patients under 50 but not in the elders.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Placement of long-term hemodialysis catheter (permcath) in patients with end-stage renal disease through external jugular vein
Ali Akbar Beigi, Ali Sharifi, Hafez Gaheri, Saeed Abdollahi, Morteza Abdar Esfahani
Adv Biomed Res
2014, 3:252 (6 December 2014)
DOI
:10.4103/2277-9175.146381
PMID
:25590030
Background:
The number of patients with End-Stage Renal Disease (ESRD) has progressively increased in the population. Kidney transplantation is the specific treatment for such patients; however a majority of patients will require hemodialysis before kidney transplantation. The present study aims to investigate using the external jugular vein (EJV) for Permcath placement in these patients.
Materials and Methods:
This descriptive and analytical study was conducted in Alzahra Medical Center, Isfahan, in 2012. Catheters were inserted by cutting down the right EJV. The patency rate and potential complications were studied. The obtained data was analyzed using SPSS 21.0.
Results:
Out of 45 live patients, within three months of surgery, 40 patients (81.6%) had no complications and dialysis continued through Permcath. Permcath Thrombosis occurred in two patients (4.4%). Catheter infection led to the removal of it in one patient (2.2%) 1.5 months after surgery. And accidental catheter removal occurred in one patient.
Conclusion:
Placement of the permcath in the external jugular vein can be a safe, uncomplicated, and reliable method for patients requiring hemodialysis, and can be a life-saving alternative in patients without accessible internal jugular vein.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (8) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Kefir protective effects against nicotine cessation-induced anxiety and cognition impairments in rats
Negin Noori, Mohammad Yasan Bangash, Majid Motaghinejad, Pantea Hosseini, Behshad Noudoost
Adv Biomed Res
2014, 3:251 (6 December 2014)
DOI
:10.4103/2277-9175.146377
PMID
:25590029
Background:
Nicotine as one of the potent psychostimulant drugs is characterized by its parasympathomimetic activity. Upon the abrupt discontinuation of nicotine intake, a number of symptoms such as anxiety, depression and cognition impairment develop. Kefir as a food supplement is rich in tryptophan. In this study, we have evaluated the effects of Kefir on nicotine cessation-induced anxiety, depression and cognition impairment.
Materials and Methods:
Forty adult male rats were divided into four groups. All the groups received 6 mg/kg/day of nicotine for 17 days and then the negative control groups got 5 mg/kg/day of normal saline. The positive control groups were given 40 mg/kg/day of Sertraline HCl for 7 days. The group treated with Cow Milk Kefir (CMK) and Soy Milk Kefir (SMK) received 5 mg/kg/day for 7 days. On the 25
th
day, Elevated Plus Maze (EPM), Open Field Test (OFT) and Forced Swim Test (FST) were used to investigate anxiety and depression. In addition, Moris Water Maze was applied to evaluate learning and memory in the animals between the 20
th
and 25
th
days.
Results:
The results showed that administration of CMK, SMK and Sertraline had higher anti-depression and anxiolytic effects on nicotine withdrawal-induced depression and anxiety in rats (
P
< 0.05). Moreover, CMK and SMK improved learning and memory impairment results in the nicotine withdrawal period (
P
< 0.05).
Conclusion:
This study revealed that Kefir had a potential effect on the treatment of nicotine cessation-induced depression, anxiety and cognition impairment in the animal model. Kefir may be useful for adjunct therapy for nicotine abandonment treatment protocols.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (10) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Case Report:
Preoperative evaluation of pelvic kidney renal cell carcinoma with 64-slice CT and 3D-CT angiography
Mohammad H Izadpanahi, Mahmoud Kabiri, Hamid Mazdak, Kia Nouri-Mahdavi, Mohammad H Khorrami
Adv Biomed Res
2014, 3:250 (6 December 2014)
DOI
:10.4103/2277-9175.146376
PMID
:25590028
We report a case of a 55-year-old woman, who presented with a vague pelvic pain and was found to have an ectopic pelvic kidney involved by a mass. Preoperative assessment was done by multi-slice CT and 3D-CT angiography. According to our knowledge only eight cases of pelvic kidney tumor have been reported in the literature and our case is the first report of using multi-slice CT and 3D-CT angiography in the preoperative evaluation of these cases.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
The frequency of agitation due to inappropriate use of naltrexone in addicts
Sima Siadat, Nastaran Eizadi-Mood, Ali Mohammad Sabzghabaee, Farzad Gheshlaghi, Ahmad Yaraghi
Adv Biomed Res
2014, 3:249 (6 December 2014)
DOI
:10.4103/2277-9175.146373
PMID
:25590027
Background:
There is a high tendency among specialists to treat the addicts with naltrexone; withdrawal symptoms are frequent after taking naltrexone along with opioids. This study investigated the frequency of agitation due to inappropriate use of naltrexone in addicts.
Materials and Methods:
This was a cross-sectional study, conducted in Noor and Aliasghar hospitals in Isfahan city. The study population included the addicts who were agitated as a result of naltrexone abuse. Scores of patients with agitation were measured with Richmond Agitation Sedation Scale (RASS). Patient outcomes including recovery without complications, recovery with complications (rhabdomyolysis), and mortality were recorded.
Results:
All the patients with agitation caused by naltrexone abuse during 1 year were 40 people, of whom nine were excluded due to their comorbid diseases (diabetes or cardiovascular disease). Among the remaining 31 patients, 30 were male. The patients' mean age was 29.93 (5.24) years. The most common symptoms observed besides agitation was midriasis (41.9%), and vomiting (41.9%), A 38.8% of the patients scored 3 or 4, and, 61.2% scored 1 or 2 for agitation. The mean time for patients' restlessness scores to reach zero was 9.30 (3.71) h (min: 3 h, max: 18 h). All the patients in both groups were discharged with recovery without complication.
Conclusion:
Considering the high prevalence of agitation in the poisoning emergency department due to inappropriate use of naltrexone, more accurate planning for administration of naltrexone in addicts seems necessary.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
A comparison between standard triple therapy and sequential therapy on eradication of
Helicobacter pylori
in uremic patients: A randomized clinical trial
Atieh Makhlough, Hafez Fakheri, Ahmad Ramezani Farkhani, Omid Seddighi, Seyed Vahid Hossieni, Mohammad Khademloo, Zohreh Bari
Adv Biomed Res
2014, 3:248 (6 December 2014)
DOI
:10.4103/2277-9175.146372
PMID
:25590026
Background:
The prevalence of peptic ulcer disease in hemodialysis dependent patients is higher than the general population. These patients are also more prone to upper gastrointestinal bleeding. The aim of this study was to compare the effects of a standard triple therapy with a sequential therapy on
Helicobacter
pylori
eradication in azotemic and hemodialysis patients.
Materials and Methods:
Forty nine hemodialysis and azotemic patients, naïve to
H.
pylori
treatment, were randomized into two groups to receive either standard triple therapy (pantoprazole 40 mg, amoxicillin 500 mg and clarithromycin 250 mg twice a day for 14 days) or a sequential therapy (pantoprazole 40 mg for 10 days, amoxicillin 500 mg twice a day for the first 5 days and clarithromycin 250 mg + tinidazole 500 mg twice a day just during the second 5 days).
H.
pylori
eradication was evaluated by fecal
H.
pylori
antigen assessment 8 weeks after the treatment.
Results:
Of 49 patients, 45 patients (21 in triple therapy group and 24 in the sequential group) completed the study. Based on intention to treat analysis,
H.
pylori
eradication rates were 66.7% (95% confidence interval [CI]: 47.8-85.5%) in standard triple therapy group and 84% (95% CI: 69.6-98.3%) in sequential therapy group (
P
= 0.34
)
. Per-protocol (PP) eradication rates were (95% CI: 76.2%. 6-89.3%) 54 and 87.5% (95% CI: 68.8-95.5%), respectively (
P
= 0.32).
Conclusion:
According to Maastricht III consensus report, the results of our study showed that sequential therapy might be a better choice compared with the standard triple therapy in azotemic and hemodialysis patients Iran. We propose to assess the effects of shorter-duration sequential therapy (less than 10 days) for
H.
pylori
eradication.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (4) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Review Article:
Immunocontraceptives: How far from reality?
Seema Lekhwani, ND Vaswani, Veena Singh Ghalaut, Vijay Shanker, Ragini Singh
Adv Biomed Res
2014, 3:247 (6 December 2014)
DOI
:10.4103/2277-9175.146369
PMID
:25590025
Despite high expectations of safer, effective, economical, longer acting contraceptives, to date, there are no licensed contraceptive vaccines available in the market. Nevertheless, a role for vaccines undoubtedly exists as an aid to birth spacing and as a nonsurgical means of generating sterility. The research concerned in the area so far has been successful on the feline population, with room still for exhaustive studies on humans. The future of contraceptive vaccines holds great promise in terms of comfort, price, efficacy, rare complications, and possibly nonselective action on animal populations as well as on humans. This brief review deals with the basic aspects of immunocontraceptives along with the efforts done so far. There is a need for further research in aspects involving the rate of evolution of contraception resistance based on genetics, resistance phenotypes, or cross generation effects. Gonadotropin-releasing hormone and luteinizing-hormone have not been investigated in humans, as both reported impotency in animals; the follicle-stimulating hormone has been shown to cause oligospermia; zona pellucida has also not been studied in humans as it causes irreversible oophoritis, while the sperm has the potential for success in humans based on the data from immunoreproductive studies. Even as the position of the human chorionic gonadotropin vaccine looks hopeful, research on other possible targets continue with an eventual aim of discovering a vaccine that is more immunogenically effective.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
The Serum and salivary level of malondialdehyde, vitamins A, E, and C in patient with recurrent aphthous stomatitis
Heidar Khademi, Faezeh Khozeimeh, Atefeh Tavangar, Sima Amini, Parichehr Ghalayani
Adv Biomed Res
2014, 3:246 (6 December 2014)
DOI
:10.4103/2277-9175.146366
PMID
:25590024
Background:
Oral recurrent aphthous stomatitis (RAS) is a chronic inflammatory disease affected oral mucosa which has afflicted about 20% of the society. Etiology of this disease is unknown. Three main factors influencing aphthous stomatitis are genetic, hematologic, and immunologic factors. Another proposed factor that may be considered in etiology of aphthous ulcer is oxidant, anti-oxidant imbalance in the body. The purpose of this study was the evaluation of lipid peroxide enzyme as an important oxidant agent and anti-oxidant vitamins in the saliva and serum of the patients suffering from RAS and compare it to healthy people.
Materials and Methods:
In this cross-sectional, descriptive - analytical study, 25 patients suffering from RAS were compared to 24 healthy individuals. Applying enzyme-linked immunosorbent assay method, the amount of malondialdehyde (MDA) as well as Vitamins A, E, and C were measured in the saliva and serum of two groups. The results were analyzed by Statistical Package for the Social Sciences (SPSS) software version (11.5),
t
-test and χ
2
.
Results:
No significant difference was detected between salivary and serum levels of antioxidant vitamins (A, E, and C) and MDA in both experimental groups (
P
> 0.05).
Conclusion:
According to the results of this study, RAS is not associated with oxidant-antioxidant imbalance in the body. However, it seems quite necessary to carry out more studies in this area.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (7) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Original Article:
Comparison between antibiotic therapy of
Brucellosis
with and without vitamin A
Marziyeh Salehi, Hassan Salehi, Mohamad Mahdi Salehi, Maryam Salehi
Adv Biomed Res
2014, 3:245 (6 December 2014)
DOI
:10.4103/2277-9175.146365
PMID
:25590023
Background:
Brucellosis is one of the endemic diseases in our country and it can be in the types of acute, sub-acute or chronic. It estimates that about 20% of Brucellosis may change from acute to chronic. Because cell mediated immunity (CMI) is the main defense of body against
Brucella
species, it seems that some degree of Immunologic disorders existed in the patients with chronic form of diseases and some supplements such as Vitamin A (Vit A) as an immunomodulator can stimulate CMI and may decrease the rate of chronicity.
Materials
and
Methods:
In a single-blind randomized clinical trial 120 patients with the clinical and serological diagnosed Brucellosis were randomized. A total of 60 patients received streptomycin and Doxycycline as standard therapy for 6 weeks and others in addition to this Regimen received Vit A for about 4 weeks.
Results:
In the case group, only 1 case (1.6%) relapsed and in the control group 8 (13.5%) with significant difference (
P
< 0.005) between two groups. Morbidity of disease was different between two groups.
Conclusion:
Vit A therapy in the patients with Brucellosis with may reduce the disease morbidity and rate of chronicity.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Feedback
Subscribe
Advanced Search
Month wise articles
Figures next to the month indicate the number of articles in that month
2021
March
[
2
]
February
[
4
]
January
[
6
]
2020
December
[
8
]
November
[
7
]
October
[
13
]
September
[
10
]
August
[
10
]
July
[
7
]
June
[
4
]
May
[
5
]
April
[
5
]
March
[
3
]
February
[
4
]
January
[
5
]
2019
December
[
2
]
November
[
5
]
October
[
5
]
September
[
7
]
August
[
6
]
July
[
3
]
June
[
7
]
May
[
5
]
April
[
8
]
March
[
6
]
February
[
8
]
January
[
10
]
2018
December
[
9
]
November
[
9
]
October
[
11
]
September
[
5
]
August
[
10
]
July
[
10
]
June
[
13
]
May
[
17
]
April
[
17
]
March
[
19
]
February
[
19
]
January
[
20
]
2017
December
[
13
]
November
[
21
]
October
[
12
]
September
[
9
]
August
[
15
]
July
[
22
]
June
[
11
]
May
[
14
]
April
[
14
]
March
[
21
]
February
[
8
]
January
[
8
]
2016
December
[
17
]
November
[
20
]
October
[
12
]
September
[
9
]
August
[
19
]
July
[
16
]
June
[
17
]
May
[
17
]
April
[
16
]
March
[
36
]
February
[
14
]
January
[
14
]
2015
December
[
2
]
November
[
15
]
October
[
25
]
September
[
29
]
August
[
29
]
July
[
31
]
June
[
11
]
May
[
39
]
March
[
15
]
February
[
29
]
January
[
34
]
2014
December
[
23
]
November
[
25
]
October
[
18
]
September
[
19
]
August
[
22
]
July
[
13
]
June
[
11
]
May
[
22
]
April
[
2
]
March
[
24
]
February
[
11
]
January
[
77
]
2013
November
[
10
]
October
[
5
]
August
[
1
]
July
[
23
]
June
[
11
]
March
[
42
]
2012
December
[
4
]
October
[
17
]
August
[
34
]
July
[
15
]
May
[
10
]
March
[
7
]
1900
January
[
1
]
Sitemap
|
What's New
|
Feedback
|
Disclaimer
© Advanced Biomedical Research | Published by Wolters Kluwer -
Medknow
Online since 15 January, 2012