Users Online: 1053
Home Print this page Email this page
Home About us Editorial board Search Browse articles Submit article Ahead of Print Instructions Subscribe Contacts Special issues Login 
Year : 2019  |  Volume : 8  |  Issue : 1  |  Page : 49

An Overview of the CRISPR-Based Genomic- and Epigenome-Editing System: Function, Applications, and Challenges

1 Department of Medical Genetics, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Neuroscience, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Dr. Majid Mojarrad
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/abr.abr_41_19

Rights and Permissions

Developing a new strategy for an efficient targeted genome editing has always been a great perspective in biology. Although different approaches have been suggested in the last three decades, each one is confronting with limitations. CRISPR-Cas complex is a bacterial-derived system which made a breakthrough in the area of genome editing. This paper presents a brief history of CRISPR genome editing and discusses thoroughly how it works in bacteria and mammalians. At the end, some applications and challenges of this growing research area are also reviewed. In addition to moving the boundaries of genetics, CRISPR-Cas can also provide the ground for fundamental advances in other fields of biological sciences.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded667    
    Comments [Add]    
    Cited by others 4    

Recommend this journal