Users Online: 129
Home Print this page Email this page
Home About us Editorial board Search Browse articles Submit article Ahead of Print Instructions Subscribe Contacts Special issues Login 

Previous article Browse articles Next article 
Adv Biomed Res 2017,  6:29

Presentation of Placental Site Trophoblastic Tumor with Amenorrhea

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Date of Web Publication07-Mar-2017

Correspondence Address:
Safoura Rouholamin
Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2277-9175.201686

Rights and Permissions

Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy. During curettage, necrotic tissue was removed and severs vaginal bleeding was controlled with medical therapy. Histology examination showed neoplastic intermediate trophoblastic cells with invasion to the vessel wall compatible with PSTT. After that, hysterectomy was down and serum βhCG declined to undetectable level 2 weeks after surgery and was followed for 2 years without complication.

Keywords: Placental site throphoblastic tumor, amenorrhea, vaginal bleeding

How to cite this article:
Behnamfar F, Rouholamin S, Esteki M. Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. Adv Biomed Res 2017;6:29

How to cite this URL:
Behnamfar F, Rouholamin S, Esteki M. Presentation of Placental Site Trophoblastic Tumor with Amenorrhea. Adv Biomed Res [serial online] 2017 [cited 2023 Feb 8];6:29. Available from:

  Introduction Top

Placental site throphoblastic tumor (PSTT) is an extremely rare form of the gestational throphoblastic disease (GTD) of which approximately 200 cases has been reported in the literature.[1] Histopathologically, PSTT is characterized by a neoplastic population of intermediate trophoblastic cells at the implantation site often arranged as sheets of polyhedral, round, or occasionally spindle-shaped cells that infiltrate the myometrium extensively.[2],[3] Because of the rarity of this type of tumor, there is little information about its epidemiology and etiology and few large series on diagnosis and treatment have been published.[4] Thus, report of any new cases with clinical presentation and treatment of disease is very important for characterize of this rare disease.

The serum beta human chorionic gonadotropin (βhCG) level is generally low in PSTT. Abnormal vaginal bleeding is the most common manifestation of this tumor.[5] Herein, we report a case of PSTT, who unexpectedly presented with prolonged amenorrhea.

  Case Report Top

A G6P5 31-year-old woman was referred to our center with a history of 13 weeks amenorrhea and slightly elevated serum βhCG level. On pelvic examination, she had an enlarged uterus measuring about 10–12 weeks in size. The uterus was no tender, mobile and soft. Cervix was soft and adnexes were free. Serum β-hCG level was 190 IU/ml at the time of admission. On ultrasound examination, endometrial thickening of 22 millimeter (mm) was reported. Two cystic lesions measuring 26 mm × 16 mm and 18 mm × 13 mm were seen within the endometrial cavity. These had been interpreted as a blighted ovum or missed abortion.

The patient underwent therapeutic dilation and curettage (D and C) with a preoperative diagnosis of a blighted ovum. The uterus was felt to be soft at D and C and contained necrotic tissue not resembling usual products of conception. Severe vaginal bleeding occurred after D and C. This was controlled by bimanual massage, oxytocin infusion, and rectal prostaglandin. Microscopic study of the curettage specimen revealed sheets of intermediate trophoblastic cells with abundant eosinophilic cytoplasm, large nuclei, nuclear atypia, and <2 mitoses/10 high-power fields (HPF). Fibrin deposition was seen in the background. Prominent necrosis was absent. The neoplastic intermediate trophoblastic cells showed invasion to the vessel wall. According to these microscopic findings, the diagnosis of PSTT was made for the patient [Figure 1].
Figure 1: Sheets of polygonal intermediate trophoblasts are seen in a background of fibrin deposition (×400)

Click here to view

Because of definitive diagnose of our case with the pathological examination, according to comment of our pathologist and financial problems, we did not check prolactin.

Renal and liver function tests following surgery were normal. Computed tomography (CT) of the chest and brain showed no evidence of metastasis. On pelvic CT, the uterus was large, but there was not obvious evidence of a solid mass lesion. Since the patient had five children and did not desire to preserve her fertility and the disease was limited to the uterus, hysterectomy was planned. Intraoperatively, the uterus was symmetrically enlarged and globally infiltrated by tumoral mass. Ovaries seemed normal. Total hysterectomy was done and ovaries were preserved. Pathologic study of the hysterectomy specimen revealed slightly enlarged uterus. A hemorrhagic mass was seen within the endometrial cavity showing deep myometrial and focal serosal invasion. Microscopic study of the mass confirmed the diagnosis of the placental site trophoblastic tumor. Sheets and cords of polygonal intermediate trophoblastic cells with convoluted and occasionally bilobed nuclei were seen. The cells showed nuclear atypia, invasion to the vessel wall and <2 mitoses/10 HPF and deeply extended into the myometrium in a dissecting fashion. Foci of uterine serosal involvement were also evident.

Serum βhCG declined to undetectable level 2 weeks after surgery. The patient has been followed for 2 years. She has been disease free without receiving any adjuvant treatment.

  Discussion Top

The placental site trophoblastic tumor is a rare manifestation of GTD that may complicate any type of pregnancy and presents in 0.25–5% of patients with GTD worldwide. The disease is seen mostly in women of reproductive age.[6] Most of PSTT follow a term delivery and remnant arising after abortion or molar pregnancy. Risk factors for PSTT are not well understood. The disease is unique from other GTDs, because of slow growth, low hCG serum levels, late onset metastasis and the relative insensitivity to chemotherapy.[7],[8] Due to the rarity of this type of GTD, reporting new cases and their presentations are important to improve PSTT diagnosis and treatment.

Abnormal vaginal bleeding is the most common presentation of the disease. Other presentations include amenorrhea, ruptured uterus, abdominal pain and postmenopausal bleeding in decreasing order of frequency.[5],[9] Our case presented with amenorrhea which is not a common presentation of the disease. Seldom symptoms of the metastatic disease have been reported including virilization, nephrotic syndrome, and polycythemia. Most PSTT is diagnosed when a uterine lesion is seen on imaging and serum hCG is mildly elevated.[7] Behnamfar et al. from Isfahan University reported one case of PSTT presented with amenorrhea.[10] They collected other cases of PSTT that presented with amenorrhea.[10],[11] According to their report, six cases of PSTT had amenorrhea.

Hyman et al. describe the presentation, treatment, and outcome of 17 cases of PSTT in Memorial Sloan-Kettering Cancer Center. Only one patient had an interval from last antecedent pregnancy of ≥24 months and others presented with vaginal bleeding.[12]

According to a Japanese study, a correct diagnosis of PSTT is achieved in only 35% of cases on the basis of curettage specimens.[13] However, we could diagnose PSTT in our case after curettage.

Most PSTTs behave in a benign fashion, but approximately 10–15% are clinically malignant.[14] The tumors are usually nonmetastatic and remain confined to the uterus. The most common site of metastasis is lung. However, they can spread to peritoneum, liver, pancreas, and brain late in their course. Tumors with more than 5 mitoses/10 HPF have an increased propensity for metastatic disease.[15]

Surgery remains the primary mode of treatment in patients presenting with disease limited to the uterus. Remission rates of up to 100% have been reported in these cases.

Adjuvant chemotherapy in patients with Stage I or II disease is considered for patients who have risk factors for recurrence including vascular invasion, deep myometrial invasion, serosal involvement, high mitotic index and persistently elevated postoperative serum hCG concentration.[16]

In metastatic disease treatment is surgery, chemotherapy with or without radiation. The response to chemotherapy is variable, and optimum regimen for PSTT is unknown. EMA-EP regimen (etoposide, methotrexate with folinic acid, actinomycin D, and cisplatin) is a more potent regimen. However, the previous study found PSTT is not a chemosensitive tumor.[16] We treated our case successfully with abdominal hysterectomy without adjuvant or neoadjuvant chemotherapy. Undetectable levels of serum βhCG were achieved in <3 weeks after a hysterectomy. Since the patient had no extrauterine disease and had a rapid decline of hCG titer, postoperative chemotherapy was not necessary. Hysterectomy without chemotherapy has also been reported as a definitive treatment for tumors limited to the uterus in other studies.[16],[17] Our experience confirms for patients with early stage and disease confined to the uterus, surgery alone is typically sufficient.

Persistent low levels of hCG titer in parous women presenting with amenorrhea should prompt the possibility of PSTT, which will be best treated with early diagnosis when the disease is confined to the uterus.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Berkowitz RS, Goldstein DP, Horowitz NS. Management options of gestational trophoblastic disease. Curr Obstet Gynecol Rep 2014;3:76-83.  Back to cited text no. 1
Alazzam M, Hancock BW, Tidy J. Role of hysterectomy in managing persistent gestational trophoblastic disease. J Reprod Med 2008;53:519-24.  Back to cited text no. 2
Stevens FT, Katzorke N, Tempfer C, Kreimer U, Bizjak GI, Fleisch MC, et al. Gestational Trophoblastic Disorders: An Update in 2015. Geburtshilfe Frauenheilkd 2015;75:1043-50.  Back to cited text no. 3
Genest D, Berkowitz R, Fisher R, Newlands E, Fehr M. Gestational trophoblastic disease. Tavassoli FA, Devilee P, editors. World Health Organization Classification of Tumours, Tumours of the Breast and Female Genital Organs. Lyon: IARC Press; 2003. p. 203.  Back to cited text no. 4
Soper JT, Mutch DG, Schink JC; American College of Obstetricians and Gynecologists. Diagnosis and treatment of gestational trophoblastic disease: ACOG Practice Bulletin No 53. Gynecol Oncol 2004;93:575-85.  Back to cited text no. 5
Hoekstra AV, Keh P, Lurain JR. Placental site trophoblastic tumor: A review of 7 cases and their implications for prognosis and treatment. J Reprod Med 2004;49:447-52.  Back to cited text no. 6
Kohorn EI. Long-term outcome of placental-site trophoblastic tumours. Lancet 2009;374:6-7.  Back to cited text no. 7
Gulia S, Bajpai J, Gupta S, Maheshwari A, Deodhar K, Kerkar RA, et al. Outcome of gestational trophoblastic neoplasia: Experience from a tertiary cancer centre in India. Clin Oncol (R Coll Radiol) 2014;26:39-44.  Back to cited text no. 8
Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE. Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol 2006;100:511-20.  Back to cited text no. 9
Behnamfar F, Mousavi A, Rezapourian P, Zamani A. Placental site trophoblastic tumor, report of a case with unusual presentation. Placenta 2013;34:460-2.  Back to cited text no. 10
Hassadia A, Gillespie A, Tidy J, Everard RG, Wells M, Coleman R, et al. Placental site trophoblastic tumour: Clinical features and management. Gynecol Oncol 2005;99:603-7.  Back to cited text no. 11
Hyman DM, Bakios L, Gualtiere G, Carr C, Grisham RN, Makker V, et al. Placental site trophoblastic tumor: Analysis of presentation, treatment, and outcome. Gynecol Oncol 2013;129:58-62.  Back to cited text no. 12
Kashimura M, Kashimura Y, Oikawa K, Sakamoto C, Matsuura Y, Nakamura S. Placental site trophoblastic tumor: Immunohistochemical and nuclear DNA study. Gynecol Oncol 1990;38:262-7.  Back to cited text no. 13
Eckstein RP, Paradinas FJ, Bagshawe KD. Placental site trophoblastic tumour (trophoblastic pseudotumour): A study of four cases requiring hysterectomy including one fatal case. Histopathology 1982;6:211-26.  Back to cited text no. 14
Feltmate CM, Genest DR, Wise L, Bernstein MR, Goldstein DP, Berkowitz RS. Placental site trophoblastic tumor: A 17-year experience at the New England trophoblastic disease center. Gynecol Oncol 2001;82:415-9.  Back to cited text no. 15
Chang YL, Chang TC, Hsueh S, Huang KG, Wang PN, Liu HP, et al. Prognostic factors and treatment for placental site trophoblastic tumor-report of 3 cases and analysis of 88 cases. Gynecol Oncol 1999;73:216-22.  Back to cited text no. 16
Newlands ES, Mulholland PJ, Holden L, Seckl MJ, Rustin GJ. Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors. J Clin Oncol 2000;18:854-9.  Back to cited text no. 17


  [Figure 1]

This article has been cited by
1 lnc003875/miR-363/EGR1 regulatory network in the carcinoma -associated fibroblasts controls the angiogenesis of human placental site trophoblastic tumor (PSTT)
Sai Zhang,Xiang Tao,Qi Cao,Xuan Feng,Jing Wu,Huandi Yu,Yinhua Yu,Congjian Xu,Hongbo Zhao
Experimental Cell Research. 2019; : 111783
[Pubmed] | [DOI]
2 A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene-expressing stem cells to selectively target choriocarcinoma (Review)
Gyu-Sik Kim,Kyung-A Hwang,Kyung-Chul Choi
Oncology Letters. 2019;
[Pubmed] | [DOI]


Previous article  Next article
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Case Report
Article Figures

 Article Access Statistics
    PDF Downloaded303    
    Comments [Add]    
    Cited by others 2    

Recommend this journal