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Evaluation of relationship between serum levels of anti-müllerian hormone, androgen, and insulin resistant with retrieval oocytes in overweight patients with polycystic ovary syndrome
Esmat Aghadavod1, Nosratollah Zarghami2, Laya Farzadi3, Mina Zare4, Abolfazl Barzegari5, Ali Akbar Movassaghpour6, Mohammad Nouri7
1 Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz; Research Center for Biochemistry and Nutrition In Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
2 Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Biochemistry and Clinical Laboratories, Faculty of Medicine; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Tabriz, Iran
6 Hematology and Oncology Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
7 Women's Reproductive Health Research Center; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Correspondence Address:
Mohammad Nouri
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Post Box: 51656-65811, Tabriz
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2277-9175.153903
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Background: This study aimed to find a correlation between increased body mass index (BMI), insulin resistance (IR), hyperandrogenism, and anti-mullerian hormone (AMH) serum levels with the number of follicles retrieved in polycystic ovary syndrome (PCOS) patients.
Materials and Methods: The descriptive study was taken on 80 women with average ages of 20-35 years at Alzahra Hospital of Tabriz-Iran who referred for in vitro fertilization. Patients were divided into four groups and serum levels of AMH, testosterone and IR were evaluated at the puncture time.
Results: The mean number of follicle retrieved was higher in PCOS (P < 0.05) group than non-PCOS patients. There was a negative significant correlation of follicle number with BMI (r = −0.26, P < 0.05). The ratio of follicle numbers in PCOS/overweight group decreased in comparison to PCOS/normal weight group (−30%, P < 0.05) while the follicle numbers in non-PCOS/overweight patients decreased in comparison with non-PCOS/normal weight (−26%, P > 0.05). There was a significant negative association between BMI with AMH (r = −0.59, P < 0.05), BMI with the follicle numbers (r = −0.2, P < 0.05) and a positive association BMI with -IR (r = 0.3, P < 0.05), but there wasn't a significant correlation between BMI with testosterone (r = 0.1, P < 0.5).
Conclusion: Our finding provides that increasing BMI with direct effect on AMH levels and IR can affect the number of follicles, which are retrieved in these patients. |
