Users Online: 1147
Home Print this page Email this page
Home About us Editorial board Search Browse articles Submit article Ahead of Print Instructions Subscribe Contacts Special issues Login 

Previous article Browse articles Next article 
Adv Biomed Res 2015,  4:33

Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats

1 Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Iranian Traditional Medicine, School of Traditional Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Date of Submission02-Oct-2013
Date of Acceptance16-Apr-2014
Date of Web Publication30-Jan-2015

Correspondence Address:
Mousa-Al-Reza Hadjzadeh
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad
Login to access the Email id

Source of Support: Council of Research, Mashhad University of Medical Sciences, Conflict of Interest: None

DOI: 10.4103/2277-9175.150427

Rights and Permissions

Background: Hyperlipidemia is an associated complication of diabetes mellitus. Lowering of serum lipid levels seems to be associated with a decrease in the risk of vascular disease and related complications. The purpose of the current study was to evaluate the antihyperglycemic and antihyperlipidemic effects of the hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats.
Materials and Methods: Female Wistar rats were randomly divided into four groups as follows: Control, diabetic, and diabetic rats treated with the Securigera extract at doses of 100 and 200 mg/kg. The animals were rendered diabetic by a single intraperitoneal injection of 55 mg/kg streptozotocin. Diabetic rats received the Securigera extract daily in drinking water from the day on which diabetes was confirmed for 4 weeks. The levels of serum glucose and lipids were spectrophotometrically measured in all groups at weeks 0 (before diabetes induction), 2, and 4.
Results: The results showed that there was a significant increase in serum glucose, triglycerides, total cholesterol, and low density lipoprotein (LDL)-cholesterol in streptozotocin-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL)-cholesterol. Treatment of diabetic rats with S. securidaca seed extract at a dose of 200 mg/kg over a 4-week period significantly reduced the levels of serum glucose, total cholesterol, and LDL-cholesterol and increased the level of HDL-cholesterol, compared to diabetic untreated rats.
Conclusions: Securigera extract at a dose of 200 mg/kg exhibited hypoglycemic and hypolipidemic activities in streptozotocin-diabetic rats during the 4-week treatment period. This provides a valid scientific basis for using it in the treatment of diabetes in Iranian folk medicine.

Keywords: Diabetes, hyperglycemia, hyperlipidemia, rat, Securigera securidaca, streptozotocin

How to cite this article:
Rajaei Z, Hadjzadeh MA, Moradi R, Ghorbani A, Saghebi A. Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats. Adv Biomed Res 2015;4:33

How to cite this URL:
Rajaei Z, Hadjzadeh MA, Moradi R, Ghorbani A, Saghebi A. Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats. Adv Biomed Res [serial online] 2015 [cited 2023 Mar 31];4:33. Available from:

  Introduction Top

Diabetes mellitus is a chronic metabolic disease affecting about 4% of the population worldwide and its incidence is expected to increase by 5.4% in 2025. [1] Diabetes is characterized by hyperglycemia and disturbances in carbohydrate, protein, and lipid metabolism. Chronic hyperglycemia that occurs in diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. [2] Diabetes is also associated with profound alterations in the plasma lipid and lipoprotein profile and an increased risk of premature atherosclerosis, coronary insufficiency, and myocardial infarction. [3]

Despite the notable progress shown in the management of diabetes mellitus by synthetic drugs, there has been a growing interest in medicinal plants for their therapeutic properties. Herbal remedies are apparently effective, produce minimal or no side effects in clinical experience, and are of relatively low cost, as compared to oral synthetic hypoglycemic agents. [4],[5],[6]

Securigera securidaca (Fabaceae), locally known as "Gandeh Talkheh" in Persian, is an annual herb distributed in West Asia, Europe, and Africa. Phytochemical analysis of the ethanolic and aqueous extracts of S. securidaca seed has revealed the presence of flavonoids, steroidal and pentacyclic triterpenoid-type saponins, cardenolides, and tannins. [7],[8]

The seeds of the plant are used in Iranian folk medicine to treat several ailments such as hypertension, hyperlipidemia, and diabetes. [9] It has been shown that the extracts from the seeds of S. securidaca have different activities such as antiepileptic, [10] marked chronotropic, diuretic, hypokalemic, [11] and antiulcerogenic activities. [12] Till date, only limited experimental studies are available showing the antihyperglycemic and/or hypolipidemic activity of S. securidaca. The hypoglycemic effect of S. securidaca seeds has been reported in alloxan-induced diabetes. [8],[13] Recently, the effect of S. securidaca seeds in lowering serum low density lipoprotein (LDL)-cholesterol and triglyceride levels was found in hypercholesterolemic rats by Garjani et al. [14] However, none of the studies have reported on the hypolipidemic activity of S. securidaca seeds in experimental diabetes. In this study, we investigated the antihyperglycemic and hypolipidemic effects of hydroalcoholic extract of S. securidaca seeds in a streptozotocin-induced diabetic model.

  Materials and methods Top

Preparation of the hydroalcoholic extract

S. securidaca seeds were purchased from Imam Reza Pharmacy and graciously identified by Ferdowsi University herbarium, Mashhad, Iran (Herbarium Accession No. 160-1901-11). The powdered seeds (860 g) were macerated in 3200 ml of 70% ethanol/H 2 O for 72 h. Then the hydroalcoholic extract was filtered and concentrated in an oven at 40-45°C for 72 h. The resulting extract on drying gave 102.6 g (i.e. 11.86% yield) of brownish extract. The plant extract was dissolved in water for pharmacological experiments.


Female Wistar rats weighing 200-230g were housed in an air-conditioned colony room at 23 ± 2°C on a standard pellet diet and tap water ad libitum. The experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals, and the study was approved by Mashhad University of Medical Sciences.

Induction of diabetes

The overnight fasted rats were rendered diabetic by a single intraperitoneal injection of 55 mg/kg streptozotocin (Enzo Life Sciences, New York, USA) [5] freshly dissolved in cold distilled water. After 72 h of administering streptozotocin injection, serum glucose levels were measured using a glucometer (Glucocard, Kyoto, Japan). Only those animals with serum glucose higher than 250 mg/dl were selected as diabetics for the following experiments. The day on which hyperglycemia had been confirmed was designated as day 0. Diabetes was also confirmed by the presence of polyphagia, polydipsia, and polyuria during the experiment.

Experimental design

Rats were randomly allocated to four groups as follows: Control (n = 8), diabetic (n = 8), diabetics treated with the extract of Securigera in drinking water at doses of 100 mg/kg (Securigera 100 mg/kg, n = 10) and 200 mg/kg (Securigera 200 mg/kg, n = 10). The animals received the Securigera extracts in drinking water from day 0 for 4 weeks. Changes in body weight, food consumption, and water intake were regularly recorded during the experimental period. For blood sampling, the rats were fasted overnight and blood samples were obtained from retro-orbital plexus before diabetes induction (week 0) and at the end of weeks 2 and 4. Blood was allowed to clot and the serum separated by centrifugation at 3500 × g for 10 min.

Biochemical parameters

Serum concentrations of glucose, triglycerides (TG), total cholesterol (TC), and high density lipoprotein (HDL)-cholesterol were determined by enzymatic colorimetric methods using commercially available kits (Pars Azmun, Tehran, Iran) by a biochemistry analyzer (Convergys 100, Germany). The assay was performed according to the manufacturer's instructions. Very low density lipoprotein (VLDL)-cholesterol was calculated as TG/5, and LDL-cholesterol was estimated by using Friedewald formula [15] as follows:

LDL (mg/dl) = TC − (HDL + VLDL)

Statistical analysis

The data were expressed as mean ± SEM. Statistical analysis was carried out using one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test. A statistical P value less than 0.05 was considered significant.

  Results Top

Effects of Securigera extract on serum glucose levels

Measurement of serum glucose levels indicated that before diabetes induction (week 0), there were no significant differences among animals in the experimental groups [Figure 1]. Diabetic rats showed a significant increase in serum glucose levels compared to control rats at weeks 2 and 4 (P < 0.001) [Figure 1]. Treatment of diabetic rats for 2 weeks with Securigera extract at doses of 100 and 200 mg/kg did not change the serum glucose levels in comparison to untreated diabetic rats. At week 4, treatment of diabetic rats with Securigera extract at a dose of 100 mg/kg had no effect on the serum glucose levels. However, treatment with Securigera extract at a dose of 200 mg/kg significantly decreased the serum glucose levels compared to diabetic rats (P < 0.001) [Figure 1].{Figure 1}

Effects of Securigera extract on serum lipid profile

Regarding serum lipids, one-way ANOVA revealed that diabetes induction for 4 weeks caused a significant increase in TG levels compared to baseline data (P < 0.05) [Figure 2] and treatment of diabetic rats with Securigera extract had no effect on TG levels.{Figure 2}

Meanwhile, the levels of TC and LDL-cholesterol were significantly increased (P < 0.001) [Figure 3] and [Figure 4] and the levels of HDL-cholesterol were significantly decreased (P < 0.01) [Figure 5] in diabetic rats compared to control rats at week 4. Treatment of diabetic rats with Securigera extract at a dose of 200 mg/kg for 4 weeks significantly reduced the levels of TC and LDL-cholesterol (P < 0.05 and P < 0.01, respectively) [Figure 3] and [Figure 4] and significantly increased HDL-cholesterol levels compared to diabetic animals (P < 0.05) [Figure 5].{Figure 3}{Figure 4}{Figure 5}

  Discussion Top

This study was carried out in order to find the influence of daily oral administration of the hydroalcoholic extract of S. securidaca seeds for 4 weeks on plasma glucose and lipid profile in diabetic rats. In our study, streptozotocin was selected for induction of diabetes in rats. Treatment of rats with streptozotocin is an established model for inducing type 1 or insulin-dependent diabetes. In the present study, streptozotocin-induced diabetic rats showed significant increase in plasma glucose levels when compared to normal rats. The increased levels of plasma glucose were decreased upon treatment with hydroalcoholic extract of S. securidaca seeds at a dose of 200 mg/kg. Our findings are in accordance with the results of other authors who have reported the antihyperglycemic effects of S. securidaca extract in diabetic animals. [8],[11],[13] Contrary to this, Minaiyan et al. have reported that oral administration of the hydroalcoholic extract of S. securidaca at doses of 200, 400, and 800 mg/kg and intraperitoneal administration at a dose of 400 mg/kg to streptozotocin-induced diabetic rats were not able to reduce the blood glucose levels at 1, 2, 3, 4, and 8 h after treatment. [16] This discrepancy could be in part due to the acute administration of the extract and dosage of the extract. According to our results, it seems that chronic treatment with Securigera extract at lower doses is more effective in reducing the blood glucose levels in streptozotocin diabetic rats.

The hypoglycemic action of S. securidaca extract may either be due to enhanced insulin secretion from remnant pancreatic β-cells or protection of intact functional β-cells from further deterioration so that they remain active and continue to produce insulin, as observed by the significant increase in the level of insulin in diabetic treated rats. Pouramir et al. recently reported that treatment with the extract of S. securidaca seeds reduced the blood glucose levels by increasing the insulin levels in alloxan-induced diabetic rats. [13]

Hyperlipidemia is also a known complication of diabetes mellitus [17] and is characterized by increased levels of cholesterol, TG, and phospholipids and also changes in lipoproteins. [18] Hypercholesterolemia and hypertriglyceridemia in streptozotocin-induced diabetic rats are also well documented. [19] The high level of TC in blood could be considered as a major risk factor causing coronary heart disease. [20]

In our experiment, significantly increased levels of plasma TC, TG, and LDL-cholesterol and decreased levels of HDL-cholesterol were observed in streptozotocin-diabetic rats. Increased mobilization of free fatty acids from the peripheral fat depots leads to abnormally high concentration of serum lipids in diabetes, since insulin inhibits hormone-sensitive lipase. During diabetes, enhanced activity of this enzyme increases lipolysis and releases more free fatty acids into the circulation. [21] Excess production of serum fatty acids promotes the conversion of excess fatty acids into phospholipids and cholesterol in the liver. These two substances along with excess of TG formed in the liver may be discharged into the blood in the form of lipoproteins. [22]

High levels of TC and, most importantly, LDL-cholesterol are the predictors of atherosclerosis. [23] Lowering of serum lipid levels through dietary or drug therapy seems to be associated with a decrease in the risk of vascular disease and related complications. [24] In the present study, treatment with the hydroalcoholic extract of S. securidaca seeds at a dose of 200 mg/kg markedly decreased both serum TC and LDL-cholesterol levels in diabetic animals. There was also an increase in HDL-cholesterol levels, which plays an important role in the treatment of hypercholesterolemia, since several studies have shown that an increase in HDL-cholesterol is associated with a decrease in coronary risk. [25] To our knowledge, this is the first study reporting the hypolipidemic activity of S. securidaca seed extract in streptozotocin-induced diabetes. Previously, Garjani et al. had reported the effect of S. securidaca seeds in lowering serum LDL-cholesterol and TG levels in hypercholesterolemic rats. [14]

The underlying mechanism by which Securigera extract exerts its cholesterol-lowering effect seems to be by causing a decrease in cholesterol absorption from the intestine by binding with bile acids within the intestine and increasing the excretion of bile acids. [26],[27] Securigera extract can also act by decreasing the cholesterol biosynthesis, especially by decreasing the activity of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase), a key enzyme of cholesterol biosynthesis. [28],[29] In addition, Securigera seeds may treat hypercholesterolemia via enhanced uptake of LDL by increasing the LDL receptors. [30]

The phytochemical analysis of ethanolic and aqueous extracts of S. securidaca seeds has revealed the presence of flavonoids, steroidal and pentacyclic triterpenoid-type saponins, cardenolides, and tannins. [7],[8] One or more of these chemical compounds of the plant are also likely to have contributed to the observed hypolipidemic activity of the hydroalcoholic extract of S. securidaca seeds. Flavonoids function as powerful antioxidants and some are reported to have anti-diabetic activity. [31] Bhavna et al. reported that flavonoid-rich extract from the seeds of Eugenia jambolana possesses significant hypoglycemic and hypolipidemic activities in streptozotocin-induced diabetic rats. [32] Furthermore, it has been shown that saponins isolated from different plants produce significant hypolipidemic effects mainly by suppression of cholesterol luminal absorption and also by increase of cholesterol secretion through biliary excretion. [33],[34] Therefore, the hypolipidemic activity of Securigera extract can be attributed to the presence of flavonoids and saponins.

In conclusion, the hydroalcoholic extract of S. securidaca seeds showed hypoglycemic and hypolipidemic activities in streptozotocin diabetic rats during the 4-week treatment period and this confirms its use in Iranian phytomedicine. Further studies are needed to determine the constituents of the extract and the mechanism (s) by which Securigera extract exerts its anti-diabetic effects.

  Acknowledgments Top

The results presented in this work have been taken from a student's thesis. This study was supported by the Council of Research, Mashhad University of Medical Sciences.

  References Top

Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006;104:119-23.  Back to cited text no. 1
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2013;36:S67-74.  Back to cited text no. 2
Betteridge J. Lipid disorders in diabetes mellitus. In: Pickup JC, Williams G, editors. Text Book of Diabetes. London: Blackwell Science Publishers; 1997.  Back to cited text no. 3
Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J Ethnopharmacol 2005;99:75-81.  Back to cited text no. 4
Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M, Ahmadi M, Shafiee S. Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food 2013;16:206-10.  Back to cited text no. 5
Akhlaghi F, Rajaei Z, Hadjzadeh MA, Iranshahi M, Alizadeh M. Antihyperglycemic effect of Asafoetida (Ferula asafoetida oleo-gum-resin) in streptozotocin-induced diabetic rats. World Appl Sci J 2012;17:157-62.  Back to cited text no. 6
Zatula VV, Chernobrovaya NV, Kolesnikov DG. The structure of securigenin and its bioside securidaside. Chem Nat Compd 1966;2:438-9.  Back to cited text no. 7
Hosseinzadeh H, Ramezani M, Danaei AR. Antihyperglycaemic effect and acute toxicity of Securigera securidaca L. seed extracts in mice. Phytothe Res 2002;16:745-7.  Back to cited text no. 8
Amini G, editor. Iranian traditional medicinal plants (in Persian). Tehran: Medicinal Plants Research Institute; 1991.  Back to cited text no. 9
Al-Hachim GM, Maki B. Effect of Securigera Securidaca on electroshock seizure threshold in mice. Psychol Rep 1969;24:551-3.  Back to cited text no. 10
Ali AA, Mohamed MH, Kamel MS, Fouad MA, Spring O. Studies on Securigera securidacea (L.) Deg. et Dörfl. (Fabaceae) seeds, an antidiabetic Egyptian folk medicine. Pharmazie 1998;53:710-5.  Back to cited text no. 11
Mard SA, Bahari Z, Eshaghi N, Farbood Y. Antiulcerogenic effect of Securigera securidaca L. seed extract on various experimental gastric ulcer models in rats. Pak J Biol Sci 2008;11:2619-23.  Back to cited text no. 12
Pouramir M, Shahaboddin ME, Moghadamnia AA, Parastouei K. To study the effects of Securigera securidaca (L.) seed against alloxan-induced hyperglycemia. J Med Plants Res 2011;5:3188-91.  Back to cited text no. 13
Garjani A, Fathiazad F, Zakheri A, Allaf Akbari N, Azarmie Y, Fakhrjoo A, et al. The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats. J Ethnopharmacol 2009;126:525-32.  Back to cited text no. 14
Friedewald WT, Levy RI, Fredrickson DS. In: Tietz, editor. Determination of LDL cholesterol. New York: Text Book of Clinical Biochemistry; 1972.  Back to cited text no. 15
Minaiyan M, Moattar F, Vali A. Effect of Securigera securidaca seeds on blood glucose level of normal and diabetic rats. Iran J Pharm Sci 2006;2:151-6.  Back to cited text no. 16
Shew WH, Jeng CY, Lee WJ, Lin SY, Pei D, Chen YT. Simvastatin treatment in postprandial hypertriglyceridemia in type 2 diabetes mellitus patients with combined hyperlipidemia. Metabolism 2001;50:355-9.  Back to cited text no. 17
Bagdade JD, Helve E, Taskinen MR. Effect of continuous insulin infusion therapy lipoprotein surface and core lipid composition in IDDM. Metabolism 1991;40:445-9.  Back to cited text no. 18
Pushparaj P, Tan CH, Tan BK. Effects of Averrhoabilimli leaf extract on blood glucose and lipids in streptozotocin diabetic rats. J Ethnopharmacol 2000;72:69-76.  Back to cited text no. 19
Al-Shamaony L, Al-Khazraji SM, Twaiji IA. Hypoglycemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol 1994;43:167-71.  Back to cited text no. 20
Agardh CD, Bjorgell P, Nilson EP. The effect of tolbutamide on lipoproteins, and lipoproteinlipase and hormone sensitive lipase. Diabetes Res Clin Pract 1999;46:99-108.  Back to cited text no. 21
Bopanna KN, Kannan J, Sushma G, Balaraman R, Rathod SP. Antidiabetic and anti hyperlipaemic effects of neem seed kernel powder on alloxan diabetic rabbits. Indian J Pharmacol 1997;29:162-7.  Back to cited text no. 22
  Medknow Journal  
Temme EH, Van Hoydonck PG, Schouten EG, Kesteloot H. Effects of a plant sterol-enriched spread on serum lipids and lipoproteins in mildly hypercholesterolemic subjects. Acta Cardiol 2002;57:111-5.  Back to cited text no. 23
Brown GB, Xue-Qiao Z, Sacco DE, Alberts JJ. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation 1993;87:1781-91.  Back to cited text no. 24
Wilson PW. High density lipoprotein, low density lipoprotein and coronary heart disease. Am J Cardiol 1990;66:7A-10.  Back to cited text no. 25
Kritchevsky D. Fiber, lipids and atherosclerosis. Am J Clin Nutr 1978;31S: 65-74.  Back to cited text no. 26
Kelly JJ, Tsai AC. Effect of pectin, gum Arabic and agar on cholesterol absorption, synthesis and turnover in rats. J Nutr 1978;108:630-9.  Back to cited text no. 27
Kedar P, Chakrabarti CH. Effects of bittergourd (Momordica charantia) seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian J Exp Biol 1982;20:232-5.  Back to cited text no. 28
Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-6.  Back to cited text no. 29
Slater HR, Packard CJ, Bicker S, Shephered J. Effects of cholestyramine on receptor mediated plasma clearance and tissue uptake of human low density lipoprotein in the rabbit. J Biol Chem 1980;255:10210-3.  Back to cited text no. 30
Vessal M, Hemmati M, Vasei M. Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats. Comp Biochem Physiol C Toxicol Pharmacol 2003;135C: 357-64.  Back to cited text no. 31
Bhavna S, Chandrajeet B, Partha R. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol 2008;46:2376-83.  Back to cited text no. 32
Francis G, Kerem Z, Makkar HP, Becker K. The biological action of saponins in animal systems: A review. Br J Nutr 2002;88:587-605.  Back to cited text no. 33
Ma HY, Zhao ZT, Wang LJ, Wang Y, Zhou QL, Wang BX. Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of dioscorea panthacia. China J Chin Materia Med 2002;27:528-31.  Back to cited text no. 34


  [Figure 1]AdvBiomedRes_2015_4_1_33_150427_f1.jpg, [Figure 2]AdvBiomedRes_2015_4_1_33_150427_f2.jpg, [Figure 3]AdvBiomedRes_2015_4_1_33_150427_f3.jpg, [Figure 4]AdvBiomedRes_2015_4_1_33_150427_f4.jpg, [Figure 5]AdvBiomedRes_2015_4_1_33_150427_f5.jpg

This article has been cited by
1 Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model
Fatemeh Khomari, Bahar Kiani, Shahin Alizadeh-Fanalou, Mohammad Babaei, Ali Kalantari-Hesari, Iraj Alipourfard, Fatemeh Mirzaei, Sahar Yarahmadi, Elham Bahreini, Víctor M. Mendoza-Núñez
Oxidative Medicine and Cellular Longevity. 2023; 2023: 1
[Pubmed] | [DOI]
2 The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review
Zahra Nasehi, Mohammad Esmaeil Shahaboddin, Sadegh Jafarnejad
Journal of Advances in Medical and Biomedical Research. 2023; 31(144): 14
[Pubmed] | [DOI]
3 Antihyperglycemic Potential of Spondias mangifera Fruits via Inhibition of 11ß-HSD Type 1 Enzyme: In Silico and In Vivo Approach
Shadma Wahab, Mohammad Khalid, Mohammed H. Alqarni, Mohamed Fadul A. Elagib, Ghadah Khaled Bahamdan, Ahmed I. Foudah, Tariq M. Aljarba, Mons S. Mohamed, Nazik Salih Mohamed, Muhammad Arif
Journal of Clinical Medicine. 2023; 12(6): 2152
[Pubmed] | [DOI]
4 Investigation of the Chemical Composition, Antihyperglycemic and Antilipidemic Effects of Bassia eriophora and Its Derived Constituent, Umbelliferone on High-Fat Diet and Streptozotocin-Induced Diabetic Rats
Abdulaziz K. Al Mouslem, Hany Ezzat Khalil, Promise Madu Emeka, Ghallab Alotaibi
Molecules. 2022; 27(20): 6941
[Pubmed] | [DOI]
5 Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats
Meline Gomes Gonçalves, Matheus Anselmo Medeiros, Licyanne Ingrid Carvalho de Lemos, Lucia de Fátima Campos Pedrosa, Pedro Paulo de Andrade Santos, Bento João Abreu, João Paulo Matos Santos Lima
Nutrients. 2022; 14(3): 431
[Pubmed] | [DOI]
6 Middle East Medicinal Plants in the Treatment of Diabetes: A Review
Alaa M. Abu-Odeh,Wamidh H. Talib
Molecules. 2021; 26(3): 742
[Pubmed] | [DOI]
7 Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide
Mohammad Babaei,Shahin Alizadeh-Fanalou,Alireza Nourian,Sahar Yarahmadi,Navid Farahmandian,Mohsen Nabi-Afjadi,Iraj Alipourfard,Elham Bahreini
Reproductive Biology and Endocrinology. 2021; 19(1)
[Pubmed] | [DOI]
8 The effect of Aqueous, Ethanolic extracts ofRheum ribeson insulin sensitivity, inflammation, oxidative stress in patients with type 2 diabetes mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial
Atie Ghafouri,Ghazaleh hajiluian,Sahar Jafari karegar,Sharieh Hosseini,Shahrzad Shidfar,Mohammad Kamalinejad,Fatemeh AghaHosseini,Iraj Heydari,Farzad Shidfar
Journal of Herbal Medicine. 2020; : 100389
[Pubmed] | [DOI]
9 Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats
Shahin Alizadeh-Fanalou,Mohammad Babaei,Asieh Hoseini,Namamali Azadi,Ali Nazarizadeh,Asieh Shojaii,Mohammad Borji,Hassan Malekinejad,Elham Bahraini
Journal of Ethnopharmacology. 2019; : 112331
[Pubmed] | [DOI]
10 Antidiabetic Activity of Aqueous Seed Extract of Securigera securidaca in Streptozotocin Induced Diabetic Rats
Mohammad Azadbakht,Seyyedeh Atiyeh Ahmadi,Nematollah Ahangar
Journal of Advances in Medical and Biomedical Research. 2019; 27(123): 16
[Pubmed] | [DOI]
11 Effects of Securigera securidaca (L.) Degen & Dorfl seed extract combined with glibenclamide on paraoxonase1 activity, lipid profile and peroxidation, and cardiovascular risk indices in diabetic rats
Shahin Alizadeh-Fanalou,Ali Nazarizadeh,Mohammad Babaei,Mohsen Khosravi,Navid Farahmandian,Elham Bahreini
BioImpacts. 2019; 10(3): 159
[Pubmed] | [DOI]
12 Protective roles of crude and fractions of A. senegalensise carpel against alloxan-induced hyperglycemia and hyperlipidemia in rats
Sophia Shekwoyan Maikai,Rofiyat Omolara Raji,Hadiza Lami Muhammad,Abdulkadir Abubakar
Comparative Clinical Pathology. 2019;
[Pubmed] | [DOI]
13 Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats
Michelo Banda,James Nyirenda,Kaampwe Muzandu,Gibson Sijumbila,Steward Mudenda
Frontiers in Pharmacology. 2018; 9
[Pubmed] | [DOI]
14 Hypolipidemic activity of Tamarix articulata Vahl. in diabetic rats
Morad Hebi,Mohamed Eddouks
Journal of Integrative Medicine. 2017; 15(6): 476
[Pubmed] | [DOI]


Previous article  Next article
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Materials and me...
Article Figures

 Article Access Statistics
    PDF Downloaded428    
    Comments [Add]    
    Cited by others 14    

Recommend this journal