| ORIGINAL ARTICLE |
|
| Year : 2015 | Volume
: 4
| Issue : 1 | Page : 25 |
|
|
Persistence of endothelial cell damage late after Kawasaki disease in patients without coronary artery complications
Nasser Mostafavi1, Shaghayegh Haghjooy-Javanmard2, Nahid Presidend3, Nayereh Siyah Manssori4, Roya Kelishadi5
1 Departments of Pediatrics, Infectious Diseases and Tropical Medicine Research Center; Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence Address:
Shaghayegh Haghjooy-Javanmard
Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: The Vice Chancellor of Isfahan University of Medical
Sciences supported this study, Conflict of Interest: None  | Check |
DOI: 10.4103/2277-9175.150393
|
|
|
Background: Recent studies proposed an increased risk of atherosclerosis in patients with a history of Kawasaki disease. This study aimed to investigate the persistence of vascular injury after an acute phase of the Kawasaki disease.
Materials and Methods: We determined the number of circulating endothelial cells (CEC) in the peripheral blood of 13 patients with a history of Kawasaki disease within four to ten years, in comparison with 13 healthy relative controls. The CECs were counted as CD146+/CD34 + cells by the standard flow cytometry technique, and the independent t-test was employed to compare the mean number of CECs in the two groups.
Results: The mean number of CECs was significantly higher in patients than in controls (12 ± 3.03 vs. 2.38 ± 0.87, respectively, P < 0.001).
Conclusion: This study elucidates the persistence of vascular injury late after Kawasaki disease. This finding suggests that prolonged administration of vascular anti-inflammatory agents might be beneficial for preventing atherosclerosis in the subsequent years, in these patients. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
