| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 4
| Issue : 1 | Page : 177 |
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Evaluation of estrogen receptor expression and its relationship with clinicopathologic findings in gastric cancer
Hamid Saeidi1, Mohammad Reza Ghavam Nasiri2, Soodabeh Shahidsales2, Ali Taghizadeh Kermani2, Simin Hematti3, Seyedeh Setareh Roodbari1, Mohammad Hossein Mottaghi Shahri4, Sepideh Chagharvand1
1 Cancer Research Center, Guilan University of Medical Science (GUMS), Guilan, Iran
2 Cancer Research Center, Faculty of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran
3 Department of Radiotherapy and Oncology, School of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran
4 General Physicians, Cancer Research Center, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
Correspondence Address:
Soodabeh Shahidsales
Assistant Professor of Radiation Oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad
Iran
 Source of Support: This study was supported by a grant (no. 87397) from Mashhad University of Medical Sciences,, Conflict of Interest: None declared.  | Check |
DOI: 10.4103/2277-9175.164013
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Background: The presence of estrogen receptor alpha has been reported in the cell and tissue levels in gastric cancer; however, its impact on patients' survival remains unclear. The aim of this study was to investigate the expression of estrogen receptor in gastric carcinoma as well as its relationship with the clinicopathologic findings of the patients.
Materials and Methods: The study was performed on 100 endoscopic biopsies of gastric adenocarcinoma for estrogen receptor expression using an immunohistochemical method, and their relationship with the clinicopathologic findings of the patients, such as age, gender, tumor site, size, grade, depth of tumor invasion (T), and lymphatic status (N), were analyzed using independent sample t-test and Pearson Chi-square test. A P < 0.05 was considered significant in all analyses.
Results: Using an immunohistochemical method on endoscopic biopsies of 74 males and 26 females with the mean age of 63 years, estrogen receptor was found to be positive in 41% of patients. No significant difference was found between estrogen receptor expression and other clinicopathologic findings (P = 0.75). There was a significant difference between estrogen receptor (+) and estrogen receptor (−) groups in nodal involvement (P = 0.001). The estrogen receptor (+) patients had more number of lymph nodes involved.
Conclusion: This study showed that lymph node involvement has a significant relationship with estrogen receptor expression. However, no significant relationship was found between estrogen receptor expression and other clinicopathologic findings such as age, gender, tumor site in stomach, tumor size, tumor grade, and T-stage. |
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