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Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 144

HIV infection presenting as bone marrow cryptococcosis

Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra, India

Correspondence Address:
Arpana Dharwadkar
Department of Pathology, Pad Dr DY Patil Medical College, Pune, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2277-9175.135161

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Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspiration showed granulomas along with cryptococcal yeast forms. The ELISA test for detection of human immunodeficiency virus (HIV) antigen was positive. Disseminated cryptococcosis can develop as the first manifestation of HIV infection in previously healthy individuals and granulomas in such bone marrow aspiration smears are a valuable clue to an underlying opportunistic infection.

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