Cancer problem in Peutz-Jeghers syndrome

Diana Taheri; Noushin Afshar-Moghadam; Parvin Mahzoni; Amin Eftekhari; Seyed Mozafar Hashemi; Mohammad Hasan Emami; Mehdi Fesharakizadeh; Hamid Reza Ghasemi-basir

doi:10.4103/2277-9175.109721

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CASE REPORT

Year : 2013 | Volume : 2 | Issue : 1 | Page : 35

Cancer problem in Peutz-Jeghers syndrome

Diana Taheri¹, Noushin Afshar-Moghadam¹, Parvin Mahzoni¹, Amin Eftekhari², Seyed Mozafar Hashemi³, Mohammad Hasan Emami⁴, Mehdi Fesharakizadeh⁵, Hamid Reza Ghasemi-basir²
¹ Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
² Pathology Department, Isfahan University of Medical Sciences, Isfahan, Iran
³ Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
⁴ Department of Gastroenterology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
⁵ Department of Surgery, School of Medicine, Azad University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Noushin Afshar-Moghadam
Al-Zahra hospital, Soffeh Blvd, Postal code: Al-Zahra - 81744, Isfahan
Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/2277-9175.109721

Peutz-Jeghers syndrome is a rare autosomal dominantly inherited condition, characterized by the presence of hamartomatous gastrointestinal polyps and mucocutaneous pigmentation. Patients with this syndrome can be associated with other neoplasms such as ovarian neoplasms known as sex-cord tumor with annular tubules that are associated in one third of the cases with this syndrome and other types of malignancies. We report a 42-year-old woman with a history of Peutz-Jeghers Syndrome and bilateral breast cancer that presented with abnormal uterine bleeding. Total abdominal hysterectomy with bilateral salpino-oophorectomy was done and an ovarian sex cord tumor with annular tubules was incidentally diagnosed. By reviewing literatures and in agreement with previous studies we suggest routine screening for malignancies in patients with Peutz-Jeghers syndrome.

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