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Viral and nonviral delivery systems for gene delivery
Nouri Nayerossadat1, Talebi Maedeh2, Palizban Abas Ali3
1 Molecular Genetic Laboratory, Alzahra Hospital; Pediatric Inherited Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Molecular Genetic Laboratory, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Clinical Biochemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
| Date of Submission | 13-Dec-2011 |
| Date of Acceptance | 10-Mar-2012 |
| Date of Web Publication | 06-Jul-2012 |
Correspondence Address:
Nouri Nayerossadat
Molecular Genetic Laboratory, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2277-9175.98152
Gene therapy is the process of introducing foreign genomic materials into host cells to elicit a therapeutic benefit. Although initially the main focus of gene therapy was on special genetic disorders, now diverse diseases with different patterns of inheritance and acquired diseases are targets of gene therapy. There are 2 major categories of gene therapy, including germline gene therapy and somatic gene therapy. Although germline gene therapy may have great potential, because it is currently ethically forbidden, it cannot be used; however, to date human gene therapy has been limited to somatic cells. Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects. In this review we explain about the history of gene therapy, all types of gene delivery systems for germline (nuclei, egg cells, embryonic stem cells, pronuclear, microinjection, sperm cells) and somatic cells by viral [retroviral, adenoviral, adeno association, helper-dependent adenoviral systems, hybrid adenoviral systems, herpes simplex, pox virus, lentivirus, Epstein-Barr virus)] and nonviral systems (physical: Naked DNA, DNA bombardant, electroporation, hydrodynamic, ultrasound, magnetofection) and (chemical: Cationic lipids, different cationic polymers, lipid polymers). In addition to the above-mentioned, advantages, disadvantages, and practical use of each system are discussed. Keywords: Chemical delivery, gene therapy, non viral delivery systems, physical delivery, viral delivery systems
How to cite this article:
Nayerossadat N, Maedeh T, Ali PA. Viral and nonviral delivery systems for gene delivery. Adv Biomed Res 2012;1:27 |
| Introduction | |  |
Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function. [1] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s). The ultimate goal of gene therapy is single administration of an appropriate material to replace a defective or missing gene. [2] The first human gene transfer was utilized in 1989 on tumor-infiltrating lymphocytes [3],[4] and the first gene therapy was done on ADA gene for treatment of patients with SCID (Severe Combined Immunodeficiency Defect) in 1990. [5] Although initially the main focus of gene therapy was on inherited genetic disorders, now diverse diseases, including autosomal or X-linked recessive single gene disorders (CF(Cystic Fibrosis), ADA (Adenosine Deaminase) -SCID, emphysema, retinitis pigmentosa, sickle cell anemia, phenylketonuria, hemophilia, DMD (Duchenne Muscular Dystrophy), some autosomal dominant disorders, even polygenic disorders, different forms of cancers, vascular disease, neurodegenerative disorders, inflammatory conditions, and other acquired diseases are targets of gene therapy. To date, thousands of disorders have been treated by more than hundreds of protocols of gene therapy. [1] There are 2 major categories of gene therapy: Germline gene therapy and somatic gene therapy. Although germline gene therapy may have a great potential, because it is currently ethically forbidden, it cannot be used. [6],[7],[8] To date, human gene therapy has been limited to somatic cell alterations and there is a remarkable development in the field. There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus. Each of the delivery systems has some advantages and disadvantages, and in this review we explain about all types of gene delivery systems briefly [Figure 1].
| Different Methods of Gene Therapy | | |
Germline gene therapy
The technology of this type of gene therapy is simple as genetic abnormalities can be corrected by direct manipulation of germline cells with no targeting, and not only achieve a cure for the individual treated, but some gametes could also carry the corrected genotype. Although it almost never has been tested on humans, some different transgenic techniques have been used on other species, which include the following:
- Gene delivery to the nuclei taken from somatic cells at metaphase stage. [9],[10]
- Ex vivo alteration of egg cells, following in vitro fertilization. [11],[12]
- Manipulation of embryonic stem cells of mouse during in vitro culture by different gene delivery systems. [12],[13],[14]
- Pronuclear microinjection of exogenous DNA solution by a glass needle. [15]
- Transgenic delivery into sperm cells by direct or indirect injection to testis or other parts of the genital system. [16],[17]
Somatic gene therapy
Somatic gene therapy involves the insertion of genes into diploid cells of an individual where the genetic material is not passed on to its progeny. Somatic cell therapy is viewed as a more conservative, safer approach because it affects only the targeted cells in the patient, and is not passed on to future generations; however, somatic cell therapy is short-lived because the cells of most tissues ultimately die and are replaced by new cells. In addition, transporting the gene to the target cells or tissue is also problematic. Regardless of these difficulties, however, somatic cell gene therapy is appropriate and acceptable for many disorders.
There are 3 types of somatic gene therapy
Ex vivo delivery
In this system the genetic material is explanted from the target tissue or bone marrow, cultivated and manipulated in vitro, and then transducted and/or transfected into the target tissue. There are no immunologic problems in this way but only the technique is used in cases where the target cells act as protein secretion resources (like the treatment of ADA or hemophilia) or as a vaccine for cancer treatment, so there are major limitations on the use of ex vivo delivery. In addition, at present only a small percentage of reimplanted cells remain viable. [18],[19]
In situ delivery
The administration of the genetic material directly into the target tissue is in situ delivery. As most of the current delivery systems need no effective targeting, the way is proper. The system has been utilized in the delivery of CFTR gene by lipid and adenoviral vectors to a specific site in the respiratory tract and is also used in the treatment of different cancers. However, low efficiency of transduction is the main problem of this system, because in cancer therapy one malignant cell can re-establish the tumor again. [20],[21],[22]
In vivo delivery
The transfer of genetic material through an appropriate vector, which can be a viral or nonviral vector, into the target tissue is in vivo delivery. This technique is the least advanced strategy at present but potentially it might be the most useful. The problem of this way is insufficient targeting of vectors to the correct tissue sites; however, improvement in targeting and vector development will solve the problem.
| Different Vector Systems for Gene Delivery | | |
Viral vectors
One of the successful gene therapy systems available today are viral vectors, such as retrovirus, adenovirus (types 2 and 5), adeno-associated virus, herpes virus, pox virus, human foamy virus (HFV), and lentivirus. [23] All viral vector genomes have been modified by deleting some areas of their genomes so that their replication becomes deranged and it makes them more safe, but the system has some problems, such as their marked immunogenicity that causes induction of inflammatory system leading to degeneration of transducted tissue; and toxin production, including mortality, the insertional mutagenesis; and their limitation in transgenic capacity size. [24],[25] During the past few years some viral vectors with specific receptors have been designed that could transfer the transgenes to some other specific cells, which are not their natural target cells (retargeting). [26]
Retroviral vectors
Retroviral vectors are one of the most frequently employed forms of gene delivery in somatic and germline gene therapies. Retroviruses in contrast to adenoviral and lentiviral vectors, can transfect dividing cells because they can pass through the nuclear pores of mitotic cells; this character of retroviruses make them proper candidates for in situ treatment. [27],[28] In addition, all of the viral genes have been removed, creating approximately 8 kb of space for transgenic incorporation. Retroviruses are useful for ex vivo delivery of somatic cells because of their ability to linearly integrate into host cell genome; for example, they have been used for human gene therapy of X-SCID successfully but incidence of leukemia in some patients occurred because of integration of retroviruses to the LMO2 gene and inappropriate activation of it. [29],[30],[31],[32],[33],[34] Retroviral vectors also have been applied for familial hyperlipidemia gene therapy and tumor vaccination. However, the main limitations of retroviral vectors are their low efficiency in vivo, immunogenic problems, the inability to transduce the nondividing cells and the risk of insertion, which could possibly cause oncogene activation or tumor-suppressor gene inactivation. [27],[28],[29],[30],[31],[32],[33],[34]
Adenoviral vectors
Adenoviral vectors have been isolated from a large number of different species, and more than 100 different serotypes have been reported. Most adults have been exposed to the adenovirus serotypes most commonly used in gene therapy (types 2 and 5). Adenoviruses type 2 and 5 can be utilized for transferring both dividing and nondividing cells and have low host specificity so can be used for gene delivery into large range of tissues. [35] Adenoviruses are able to deliver large DNA particles (up to 38 kb), [36] but in contrast to retroviruses, as they would not integrate into the host genome, their gene expression is too short term. Natural and acute immunologic responses against adenoviruses have made their clinical application limited to a few tissues, such as liver, lung (especially for CF(Cystic Fibrosis) treatment), or localized cancer gene therapy. Although the risk of serious disease following natural adenovirus infection is rare and the viral genome would not integrate into the host genome, gene therapy by adenoviral vectors has caused serious bad side effects and even death of some patients. [37],[38],[39],[40] Recently, in addition to safety of these vectors, several essential genes have been deleted so that viral replication can only occur under control and also most of the viral genome is deleted to obtain sufficient space for 38 kb of transgene particles, this kind of adenoviruses are called "gutless" or "pseudo" adenoviruses.
Adeno-associated vectors
Adeno-associated vectors (AAV) are like adenoviral vectors in their features but because of having some deficiency in their replication and pathogenicity, are safer than adenoviral vectors. [41] In human, AAVs are not associated with any disease. Another special character of AAV is their ability to integrate into a specific site on chromosome 19 with no noticeable effects cause long-term expression in vivo. The major disadvantages of these vectors are complicated process of vector production and the limited transgene capacity of the particles (up to 4.8 kb). AAVs have been used in the treatment of some diseases, such as CF, hemophilia B, Leber congenital amaurosis, and AAT (Alpha-1 antitrypsine) deficiency. [41],[42],[43],[44]
Helper-dependent adenoviral vector
Helper-dependent adenoviral vector (HdAd), called also as "gutless" or "gutted" vector, are last generation of adenovirus vectors. [35] The disadvantages of the first-generation AdV, such as a packaging capacity limitation (8 kb), immunogenicity, and toxicity, could be overcome, with the development of high-capacity "gutless" Advs (HC-AdV). In this helper-dependent vector system, one vector (the helper) contains all the viral genes required for replication but has a conditional gene defect in the packaging domain. The second vector contains only the ends of the viral genome, therapeutic gene sequences, and the normal packaging recognition signal, which allows selectively packaged release from cells. [46] Therefore, this helper-dependent system reduces toxicity but helps prolonged gene expression of up to 32 kb of foreign DNA in host cells. Nowadays, gutless adenovirus is administered in different organs, such as muscle, liver, and central nervous system. [45],[46],[47],[48],[49],[50],[51]
Hybrid adenoviral vectors
Hybrid adenoviral vectors are made of the high transduction efficiency of a gene-deleted adenoviral vector and the long-term genome-integrating potential of adeno-associated and retroviruses viruses. Such hybrid systems show stable transduction and limited integration sites. [52],[53] Among integrating vectors, those derived from retroviruses are most common. One of the family of Retroviridae are called spuma retroviruses or foamy viruses (FVs). FVs are a group of apparently nonpathogenic nonhuman retroviruses, which have been developed only recently. [54],[55] The potential advantages of FV vectors include a broad range of hosts, the largest packaging capacity of any retrovirus, and the ability to persist in quiescent cells. Because of these features, FVs have the unique potential to safely and efficiently deliver several genes into a number of different types of cells. [56],[57]
Herpes simplex virus
Herpes simplex virus (HSV) is one of the recent viruses candidate in gene delivery. HSV systems include the development of the so-called disabled infectious single copy (DISC) viruses, which comprise a glycoprotein H defective mutant HSV genome. When the defective HSV propagated in complementing cells' viral particles are generated, they can infect in subsequent cells permanently replicating their own genome but not producing more infectious particles. [58] Herpes vectors can deliver up to 150 kb transgenic DNA and because of its neuronotropic features, it has the greatest potential for gene delivery to nervous system, [59] tumors, and cancer cells. [60],[61],[62],[63],[64]
Lentiviruses
Lentiviruses are a subclass of retroviruses. They have recently been used as gene delivery vectors due to their ability to naturally integrate with nondividing cells, which is the unique feature of lentiviruses as compared with other retroviruses, which can infect only the dividing cells. Lentiviral vectors can deliver 8 kb of sequence. Because lentiviruses have strong tropism for neural stem cells, extensively used for ex vivo gene transfer in central nervous system with no significant immune responses and no unwanted side effects. Lentiviral vectors have the advantages of high-efficiency infection of dividing and nondividing cells, long-term stable expression of a transgene, low immunogenicity, and the ability to accommodate larger transgenes. [65],[66],[67]
There are numerous examples of effective long-term treatment of animal models of neurologic disorders, such as motor neuron diseases, Parkinson, Alzheimer, Huntington's disease, lysosomal storage diseases, and spinal injury. [68],[69],[70],[71],[72],[73]
Poxvirus vectors
Poxvirus vectors are members of the Poxviridae family that are widely used for high-level cytoplasmatic expression of transgenes. The high stable insertion capacity (more than 25 KB) of this virus is the most advantageous feature of it for gene delivery. The insertion of the transgene sequences is somewhat different from the other vector systems and utilizes homologous recombination or in vitro ligation for construction of recombinant vaccinia virus vectors. [74],[75],[76] Poxviruses have been used for cancer therapy in various studies, such as prostate cancer, colorectal cancer, breast cancer, and lung cancer. [77],[78] Recombinant vaccinia virus vectors were also used for expression of E6 and E7 0genes of human papilloma virus types 16 and 18 in cervical cancer patients to induce tumor regression. [79]
There are some problems in utilizing poxviruses for gene delivery because of their complex structure and biology, so further studies are required to improve their safety and to reduce the risk of cytopathic effects.
Epstein-Barr virus
Epstein-Barr virus as a herpes virus can be used for the expression of large DNA fragments in target cells. Because Epstein-Barr virus (EBV) establishes itself in the host nucleus in a latent state as extrachromosomal circular plasmid, this virus is suitable for long-term retention in the target cell. [80],[81],[82] Because of the natural B-cell tropism of the virus, EBV-derived vectors, such as B-cell lymphoma, have been tested for immune therapy of cancer. [83]
However, other types of viruses are under investigation to date and recently, many more different virus vector systems are being developed. These are derived from vaccinia virus, human cytomegalovirus, EBV, but as mentioned earlier, problems, such as their mutagen and carcinogen properties and long-term maintenance, are major limitations in utilizing the viral vectors in gene therapy.
| Nonviral Delivery Systems | | |
Nonviral systems comprise all the physical and chemical systems except viral systems and generally include either chemical methods, such as cationic liposomes and polymers, or physical methods, such as gene gun, electroporation, particle bombardment, ultrasound utilization, and magnetofection. Efficiency of this system is less than viral systems in gene transduction, but their cost-effectiveness, availability, and more importantly less induction of immune system and no limitation in size of transgenic DNA compared with viral system have made them more effective for gene delivery than nonviral delivery systems to date. [84],[85]
Physical methods of nonviral gene delivery
Physical methods applied for in vitro and in vivo gene delivery are based on making transient penetration in cell membrane by mechanical, electrical, ultrasonic, hydrodynamic, or laser-based energy so that DNA entrance into the targeted cells is facilitated.
Naked DNA
Naked DNA alone is able to transfer a gene (2-19 kb) into skin, thymus, cardiac muscle, and especially skeletal muscle and liver cells when directly injected, [86],[87] also it has been applied directly. [87] Long-term expression has been observed in skeletal muscle following injection for more than 19 months. Single injection yields transgenic expression in less than 1% of total myofibers of the muscle but multiple injection would improve it. Although naked DNA injection is a safe and simple method, its efficiency for gene delivery is low so it is only proper for some applications, such as DNA vaccination.
DNA particle bombardant by gene gun
DNA particle bombardant by gene gun is an ideal alternative technique to injection of naked DNA. Gold or tungsten spherical particles (1-3 μm diameter) are coated with plasmid DNA and then accelerated to high speed by pressurized gas to penetrate into target tissue cells. [88] Actually it is a modification of a technique called "biolistic," originally developed for plant transgenesis, but now used for in vitro and in vivo gene delivery into mammalian cells too, [89],[90] such as skin, mucosa, or surgically exposed tissue and especially for DNA-based immunization or vaccination. [91]
Electroporation
Electroporation is temporary destabilization of the cell membrane targeted tissue by insertion of a pair of electrodes into it so that DNA molecules in the surrounding media of the destabilized membrane would be able to penetrate into cytoplasm and nucleoplasm of the cell [92],[93] but unfortunately the trangene can integrate only to 0.01% of the treated cells. [94] Electroporation has been used in vivo for many types of tissues, such as skin, muscle, lung, [95],[96],[97] HPRT gene delivery, [98] and tumor treatment. [99] There are some problems in this method too that the more important are the difficulty in surgical procedure in the placement of electrodes into the internal tissues and that the high voltage applied to tissue might damage the organ and affect genomic DNA stability. [100]
Hydrodynamic
Hydrodynamic is a simple and highly efficient method for direct intracellular delivery of any water-soluble compounds and particles into internal organs. [101] The efficiency of this simple method in vivo is higher than any other nonviral system. This method has been successful for gene delivery into rodent liver and expression of hemophilia factors, [102] cytokines, [103] erythropoietin, [104] and hepatic growth factors, [105] in mouse and rat but it has been successful only in small animals and not in human.
Ultrasound
Ultrasound can make some nanomeric pores in membrane to facilitate intracellular delivery of DNA particles into cells of internal organs or tumors, so the size and concentration of plasmid DNA have great role in efficiency of the system. [106],[107] The most important limitation of the system is low efficiency of it, especially in vivo.
Magnetofection
Magnetofection is a simple and efficient transfection method that has the advantages of the nonviral biochemical (cationic lipids or polymers) and physical (electroporation, gene gun) transfection systems in one system while excluding their inconveniences, such as low efficiency and toxicity. In this method the magnetic fields are used to concentrate particles containing nucleic acid into the target cells. [108],[109] In this way, the magnetic force allows a very rapid concentration of the entire applied vector dose onto cells, so that 100% of the cells get in contact with a significant vector dose. Magnetofection has been adapted to all types of nucleic acids (DNA, siRNA, dsRNA, shRNA, mRNA, ODN,…), nonviral transfection systems (transfection reagents) and viruses. It has been successfully tested on a broad range of cell lines, hard-to-transfect and primary cells. [110],[111]
Chemical nonviral delivery systems
Chemical systems are more common than physical methods and generally are nanomeric complexes, which include compaction of negatively charged nucleic acid by polycationic nanomeric particles, belonging to cationic liposome/micelle or cationic polymers. The nanomeric complex between a cationic liposome or micelle and nucleic acids is called lipoplex; but polyplex is the nanomeric complex formed between a cationic polymer and nucleic acids. These nanomeric complexes are generally stable enough to produce their bound nucleic acids from degradation and are competent to enter cells usually by endocytosis. [112] Cationic nonviral delivery systems have several advantages compared to other nonviral systems and especially viral vectors, such as low toxicity and antigenicity because they are made of only biological lipids, long-term expression with less risk of insertional oncogenesis but still low efficiency is the disadvantage of this system as well. Generally cationic lipids are included in 6 subcategories:
(1) Monovalent cationic lipids
(2) Polyvalent cationic lipids
(3) Guanidine containing
(4) Cholesterol derivative compounds
(5) Cationic polymers: Poly(ethylenimine) (PEI)
Poly-l-lysine) (PLL)
Protamine
Other cationic polymers [113]
(6) Lipid-polymer hybrid
Mechanism of gene delivery by cationic particles
The mechanism of gene delivery by cationic systems includes 4 steps:
- Nonspecific interaction between cationic particles and cell surface
- Endocytosis into endocytosis vesicles (endosomes)
- Compaction and release of the DNA particle from endosomes
- Translocation of the DNA particle to nucleus by membrane receptors and transgenic expression of it. [114]
For targeting of cationic particles various cell-targeting legends are covalently attached to a lipid anchor (in lipoplexes) or a DNA-binding cationic polymer (in polyplexes), [115] including proteins, [116],[117],[118] antibodies, [119],[120] small chemical compounds, [121] carbohydrates, [122] peptide ligands, [123] and vitamins, [124] some of these ligands have enhanced the vector efficiency from 10- to 1000-folds. When lipoplex or polyplex particles made association with cell surface, they would enter the cell by endocytosis. It seems more of the lipid particles in early endosomes become trapped in lysosomes and degenerate by nucleases so the interaction of endosome with lysosome is a consensus and lipoplex or polyplex particles should be released before contraction of lysosome to endosome, so fugenic peptides can help it, these peptides originating from viruses can cut off the endosomal membrane to release the genomic DNA leading to increase of genetic translocation efficiency of the liposome. [125]
In this section we focus mainly on the 2 most common cationic particles: Cationic lipids and cationic polymers:
Cationic liposomes
Cationic liposomes are the more important current nonviral polycationic systems, which compact negatively charged nucleic acids lead to the formation of nanomeric complexes. Cationic liposomes have unique characteristics, such as capability to incorporate hydrophilic and hydrophobic drugs, low toxicity, no activation of immune system, and targeted delivery of bioactive compounds to the site of action. [126],[127],[128],[129] But the rapid degradation of liposomes due to the reticuloendothelial system and the inability to achieve sustained drug delivery over a prolonged period of time are 2 drawbacks of these delivery systems that have been overcome by modification of the surface of liposomes with hydrophilic polymers, such as polyethylene glycol (PEG) [128] and integration of the pre-encapsulated drug-loaded liposomes within depot polymer-based systems. [130]
All liposomes have 1 or 2 fatty acids and alkyl moieties that are 12-18 carbons in length, in addition to a positively charged polar head group hydrophobic groups, this hydrophobic structure causes the cationic lipids. Since the first monovalent cationic lipid, DOTAP, was synthesized by Felgner et al. in 1987, [131] hundreds of new cationic liposome/micelle systems have been reported for gene delivery in vitro or in vivo. The routine way to prepare a lipoplex is mixing the solution of plasmid DNA and liposome in a proper buffer. The gene delivery efficiency of liposomes is dependent on the size, structure, and even the amount of the liposome, the charge ratio between transgenic DNA and cationic liposome, presence of helper lipid, and the structure and proportion of it and cell type.
As mentioned earlier, cationic systems are mad of either a single synthetic cationic amphiphile (cytofectin), such as DOTAP, DOTMA, DOSPA, DOGS, or more commonly of a combination of a cationic amphiphile and a neutral lipid, such as DOPE and cholesterol, these neutral helper lipids unstabilize the endosomal membrane to facilitate lipid exchange and membrane fusion between lipoplexes and endosomal membrane leading to more gene expression. [132],[133] Cationic liposome-mediated delivery of DNA materials is optimal in vivo when the mol ratio of cationic liposome to nucleic acid in the lipoplex mixture is such that the positive/negative charge ratio is around 1 or greater [134],[135],[136] and in vitro the optimal ratio is closer to 1. [137],[138],[139],[140] However, multivalent lipids with long and unsaturated hydrocarbon chains are more efficient than monovalent cationic lipids with the same hydrophobic chains. [141]
Cationic liposomes are being used in gene delivery into lung, skeletal muscles, spleen, kidney, liver, testis, heart, and skin cells. [141],[142],[143],[144],[145],[146],[147],[148]
For gene transfer in vivo, many complexes (in equimolar ratios) are used that the more general ones are Chol/DOPE (1:1), DOTMA/DOPE (1:1), and DOTAP/DOPE (1:1).
Liposome-based technology has progressed from the first-generation conventional vesicles to stealth liposomes, targeted liposomes, and more recently stimuli-sensitive liposomes. [149],[150] These new generation of liposomes overcome most of the challenges encountered by conventional liposomes, such as the inability to escape from immune system, toxicity due to charged liposomes, and low half-life stability. [151],[152],[153]
Cationic polymers
Cationic polymers at first were introduced by Wu et al.1987 184 as PLL, the same year of synthesizing the first cationic lipids, and were further expanded by a second generation, PEI by Behr et al. in 1995. [154] To date a variety of linear or branched cationic polymers have been synthesized, including PLL-containing peptides, endosomolytic peptides (histidine-rich peptides), fusogenic peptides, nuclear localization peptides (mono partite NLS(Nuclear localization signal), bipartite NLS, nonclassical NLS), proteosomes. [155] However, PLL is still the most widely studied cationic polymer and has been used in a variety of polymerizations of lysine ranging from 19 to 1116 amino acid residues (3.97-233.2 kDa). While the molecular weight of the polymer increases, the net positive charge of it also increases and are therefore able to bind DNA tighter and form more stable complexes, totally. There is a relationship between the length of the polymer, gene delivery efficiency, and toxicity as the length of the polymer increases, so does its efficiency and its toxicity. [155],[156] However, the efficiency of PLL-mediated polyplexes are low when the PLL is used alone so some conjugation agents are used to facilitate cellular uptake in vitro (as EGF(fibroblast growth factor) or transferring) or endosomal escape in vivo (as fusogenic peptides or defective viruses). Also the attachment of PEG to the polymer can prevent plasma protein binding and increase circulation of half-life of the complex. [157],[158] Different homogenous PLL-conjugated peptides have been developed that have low toxicity, higher efficiency, and site-specific attachment of ligands used for cell targeting. [159],[160],[161],[162] The optimal peptide sequence contains 18 lysines followed by a tryptophan and alkylated cysteine (AlkCWK18). A variety of branched forms of cationic peptides with a lysine as branching point have been explored. [162] PEI is the most important cationic polymer next to PLL. PEI is one of the most positively charged dense polymers, synthesized in linear (LPEI) or branched (BPEI) form, which have high transfection activity in vitro and moderate activity in vivo but the linear forms have low toxicity and high efficiency than branched forms. [163] As PLL, conjugation of some agents, such as galactose, anti-CD3 antibodies and RGD motif-containing peptides can facilitate PEI polyplex cellular uptake. [164],[165],[166] Two advantages of PEI is that it forms toroidal polyplex particles, which are stable to aggregation in physiological buffer conditions, PEI also has a strong buffering capacity at almost any pH because of the great number of primary, secondary, and tertiary amino groups. [167] One disadvantage of PEI is its nonbiodegradable nature [168] and its serious toxicity in vivo (in contrast to cationic liposome/micelle). There are conflicting associations between the gene delivery efficiency and PEI toxicity, such as PLL, the most active PEI is 25 k for BPEI and 22 k for LPEI. [169] Unfortunately, due to this property there are some limitations in the application of PEI in nonviral vector in vivo delivery. More biodegradable cationic polymers, such as aminoesters have been explored that have less toxicity than PEI and PLL. [170] However, as mentioned earlier, there are a variety of new cationic polymer groups but each of them have some advantages and disadvantages. [155] The notable factors for in vivo application are toxicity and transfection efficiency.
Lipid-polymer systems
Lipid-polymer systems are 3-part systems in which DNA is first precondensed with polycations and then coated with either cationic liposomes, anionic liposomes, or amphiphilic polymers with or without helper lipids. [171],[172],[173],[174]
| Conclusion | | |
Although numerous viral and nonviral gene delivery systems have been developed in the last 3 decades, all of them have some disadvantages that have made some limitations in their clinical application and yet no delivery system has been designed that can be applied in gene therapy of all kinds of cell types in vitro and in vivo with no limitation and side effects; however, some delivery systems has been explored, which can be efficient for gene delivery to specific cells or tissues. So it seems that the process of developing successful delivery systems, especially nonviral systems, for use in in vivo is still in its adolescence and more efforts are needed. Totally, key steps effective in improving the currently available systems include the following: (1) improving extracellular targeting and delivery, (2) enhancing intracellular delivery and long-time expression, and (3) reducing toxicity and side effects on human body. However, clinical successes in 2009-2011 have bolstered new optimism in the promise of gene therapy. These include successful treatment of patients with the retinal disease Leber congenital amaurosis, [175],[176],[177],[178] X-linked SCID, [179] ADA-SCID, [180] adrenoleukodystrophy, [180] and Parkinson's disease. [181]
| References | | |
| 1. | Stone D. Novel viral vector systems for gene therapy. Viruses 2010;2:1002-7. 
[PUBMED] [FULLTEXT] |
| 2. | Katare DP, Aeri V. Progress in gene therapy: A review. I.J.T.P.R 2010;1:33.
|
| 3. | Rosenberg SA, Aebersold P, Cornetta K, Kasid A, Morgan RA, Moen R, et al. Gene transfer into humans immunotherapy of patients with advanced melanoma, using tumor- infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 1990;323:570-8.
[PUBMED] [FULLTEXT] |
| 4. | Culver K, Cornetta K, Morgan R, Morecki S, Aebersold P, Kasid A, et al. Lymphocytes as cellular vehicles for gene therapy in mouse and man. Proc Natl Acad Sci USA 1991;88:3155-9.
[PUBMED] [FULLTEXT] |
| 5. | Blaese RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M, et al. T lymphocyte-directed gene therapy for ADA-SCID: Initial trial results after 4 years. Science 1995;270:475-80.
[PUBMED] [FULLTEXT] |
| 6. | Resnik B, Langer PJ. Human germline gene therapy reconsidered. Hum Gene Ther 2001;12:1449-58.
|
| 7. | McDonough PG. The ethics of somatic and germline gene therapy. Ann N Y Acad Sci 1997;816:378-82.
[PUBMED] [FULLTEXT] |
| 8. | Resnik DB, Langer PJ. Human germline gene therapy reconsidered. Hum Gene Ther 2001;12:1449-58.
[PUBMED] [FULLTEXT] |
| 9. | Wolf E, Schernthaner W, Zakhartchenko V, Prelle K, Stojkovic M, Brem G. Transgenic technology in farm animals-progress and perspectives. Exp Physiol 2000;85:615-25.
[PUBMED] [FULLTEXT] |
| 10. | Johnson-Saliba M, Jans DA. Gene therapy: Optimising DNA delivery to the nucleus. Curr Drug Targets 2001;2:371-99.
[PUBMED] [FULLTEXT] |
| 11. | Jaenisch R. Transgenic animals. Science 1988;240:1468-74.
[PUBMED] [FULLTEXT] |
| 12. | Smith KR. Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline. Int J Med Sci 2004;1:76-91.
[PUBMED] [FULLTEXT] |
| 13. | Hirabayashi M, Takahashi R, Ito K, Kashiwazaki N, Hirao M, Hirasawa K, et al. A comparative study on the integration of exogenous DNA into mouse, rat, rabbit, and pig genomes. Exp Anim 2001;50:125-31.
[PUBMED] [FULLTEXT] |
| 14. | Torres M. The use of embryonic stem cells for the genetic manipulation of the mous. Curr Topics Dev Biol 1998;36:99-114.
[PUBMED] |
| 15. | Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH. Genetic transformation of mouse embryos by micro-injection of purified DNA. Proc Natl Acad Sci USA 1980;77:7380-4.
[PUBMED] [FULLTEXT] |
| 16. | John PL, Kevin C, Joaquin G. Sperm and testis mediated DNA transfer as a means of gene therapy. Syst Biol Reprod Med 2011;57:35-42.
|
| 17. | Kevin S, Corrado S. Sperm-mediated gene transfer: Applications and implications. BioEssays 2005;27:551-62.
|
| 18. | Herrero MJ, Sabater L, Guenechea G, Sendra L, Montilla AI, Abargues R, et al. DNA delivery to 'ex vivo' human liver segments. Gene Ther 2011 in press.
|
| 19. | Suhonen J, Ray J, Blömer U, Gage FH, Kaspar B. Ex vivo and in vivo gene delivery to the brain. Curr Protoc Hum Genet 2006;13:Unit 13.3.
|
| 20. | Hu WW, Wang Z, Hollister SJ, Krebsbach PH. Localized viral vector delivery to enhance in situ regenerative gene therapy. Gene Ther 2007;14:891-901.
[PUBMED] [FULLTEXT] |
| 21. | Takefumi S, Akira I, Shin E, Shiro B. In Situ Gene Therapy for Prostate Cancer. Curr Gene Ther 2005;5:111-9.
|
| 22. | Davis PB, Cooper MJ. Vectors for airway gene delivery. AAPS J 2007;9:2.
[PUBMED] [FULLTEXT] |
| 23. | Huang Y, Liu X, Dong L, Liu Z, He X, Liu W. Development of Viral Vectors for Gene Therapy for Chronic Pain. Pain Res Treat 2011;2011:968218.
|
| 24. | Gardlik R, Palffy R, Hodosy J, Lukacs J, Turna J, Celec P. Vectors and delivery systems in gene therapy. Med Sci Monit 2005;11:110-21.
|
| 25. | Katare DP, Aeri V. Progress in gene therapy: A Review. I.J.T.P.R. 2010;1:33-41.
|
| 26. | Wickham TJ. Ligand-directed targeting of genes to the site of disease. Nat Med 2003;9:135-9.
[PUBMED] [FULLTEXT] |
| 27. | Anson DS. The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery. Genet Vaccines Ther 2004;2:9.
[PUBMED] [FULLTEXT] |
| 28. | Frederic D. Bushman. Retroviral integration and human gene therapy. J Clin Invest 2007;117:2083-6.
|
| 29. | Laufs S, Gentner B, Nagy KZ, Jauch A, Benner A, Naundrof S, et al. Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells. Blood 2003;101:2191-8.
|
| 30. | Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 2002;346:1185-93.
[PUBMED] [FULLTEXT] |
| 31. | Fischer A, Hacein-Bey-Aina S, Lagresle C, Garrigue A, Cavazanna-Calvo M. Gene therapy of severe combined immunodeficiency disease: Proof of principle of efficiency and safety issues. Gene therapy, primary immunodeficiencies, retrovirus, lentivirus, genome. Bull Acad Natl Med 2005;189:779-85.
|
| 32. | Buckly RH. Gene therapy for SCID: A complication after remarkable progress. Lancet 2003;360:1185-6.
|
| 33. | Fox JL. US authorities uphold suspension of SCID gene therapy. Nat Biotechnol 2003;21:217.
|
| 34. | Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-XI. Science 2003;302:415-9.
[PUBMED] [FULLTEXT] |
| 35. | Thrasher AJ, Gaspar HB, Baum C, Modlich U, Schambach A, Candotti F, et al. Gene therapy: X-SCID transgene leukaemologenicity. Nature 2006;443:E5-7.
[PUBMED] [FULLTEXT] |
| 36. | Vorburger SA, Hunt KK. Adenoviral Gene Therapy. Oncologist 2002;7:46-59.
[PUBMED] [FULLTEXT] |
| 37. | Bett AJ, Prevec L, Graham FL. Packaging capacity and stability of human adenovirus type 5 vectors. J Virol 1993;67:5911-21.
[PUBMED] [FULLTEXT] |
| 38. | Reid T, Warren R, Kirn D. Intravascular adenoviral agents in cancer patients: Lessons from clinical trials. Cancer Gene Ther 2002;9:979-86.
[PUBMED] [FULLTEXT] |
| 39. | Raper SE, Chirmule N, Lee FS, Wivel NA, Bagg A, Gao GP, et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003;80:148-58.
[PUBMED] [FULLTEXT] |
| 40. | Marshall E. Gene therapy death prompts review of adenovirus vector. Science 1999;286:2244-5.
|
| 41. | Teramato S, Ishii T, Matsuse T. Crisis of adenoviruses in human gene therapy. Lancet 2000;355:1911-2.
[PUBMED] [FULLTEXT] |
| 42. | Lai CM, Lai YK, Rakoczy PE. Adenovirus and adeno-associated virus vectors. DNA Cell Biol 2002;21:895-913.
[PUBMED] [FULLTEXT] |
| 43. | Flotte T, Carter B, Conrad C, Guggino W, Reynolds T, Rosenstein B, et al. A phase study of an adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease. Hum Gene Ther 1996;7:1145-59.
[PUBMED] [FULLTEXT] |
| 44. | Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat Genet 2000;24:257-61.
[PUBMED] [FULLTEXT] |
| 45. | Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration Molecular therapy. J Am Soc Gene Ther 2010;18:643-50.
[PUBMED] [FULLTEXT] |
| 46. | Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL, et al. Vision 1 year after gene therapy for Leber's congenital amaurosis. N Engl J Med 2009;361:725-7.
[PUBMED] [FULLTEXT] |
| 47. | Crane B, Luo X, Demaster A, Williams KD, Kozink DM, Zhang P, et al. Rescue administration of a helper dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia. Gene Ther 2011; in press.
|
| 48. | Alba R, Bosch A, Chillon M. Gutless adenovirus: Last-generation adenovirus for gene therapy. Gene Ther 2005;12:18-S27.
[PUBMED] [FULLTEXT] |
| 49. | Croyle MA, Le HT, Linse KD, Cerullo V, Toietta G, Beaudet A, et al. PEGylated helper-dependent adenoviral vectors: Highly efficient vectors with an enhanced safety profile. Gene Ther 2005;12:579-87.
[PUBMED] [FULLTEXT] |
| 50. | Amalfitano A, Hauser MA, Hu H, Serra D, Begy CR, Chamberlain JS. Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. J Virol 1998;72:926-33.
[PUBMED] [FULLTEXT] |
| 51. | Morral N, O'Neal W, Rice K, Leland M, Kaplan J, Piedra PA, et al. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc Natl Acad Sci USA 1999;96:12816-21.
[PUBMED] [FULLTEXT] |
| 52. | Balagué C, Zhou J, Dai Y, Alemany R, Josephs SF, Andreason G, et al. Sustained high-level expression of full-length human factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector. Blood 2000;95:820-8.
|
| 53. | Morral N, Parks RJ, Zhou H, Langston C, Schiedner G, Quinones J, et al. High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum Gene Ther 1998;9:2709-16.
|
| 54. | Ehrhardt A, Yant SR, Giering JC, Xu H, Engler JA, Kay MA. Somatic Integration From an Adenoviral Hybrid Vector into a Hot Spot in Mouse Liver Results in Persistent Transgene Expression Levels In Vivo. Mol Ther 2007;15:146-56.
|
| 55. | Shuji K, Kazunori H, Atsuko T, Donna JP, Philip N, Haruki O, et al. Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo. Mol Ther 2011;19:76-82.
|
| 56. | Liu W, Liu Z, Cao X, Cao Z, Xue L, Zhu F, et al. Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Mol Ther 2007;15:1834-41.
|
| 57. | Mergia A, Heinkelein M. Foamy virus vectors. Curr Topics Microbiol Immunol 2003;277:131-59.
|
| 58. | Trobridge GD. Foamy virus vectors for gene transfer. Exp Opin Biol Ther 2009;9:1427-36.
|
| 59. | Liu W, Liu Z, Liu L, Xiao Z, Cao X, Cao Z, et al. A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. Neurosci Lett 2008;432:13-8.
|
| 60. | Burtton EA, Wechuck JB, Wendell SK, Goins WF, Fink DJ, Glorioso JC. Multiple applications for replication-defective Herpes simplex virus vectors. Stem Cell 2001;19:358-77.
|
| 61. | Berto E, Bozac A, Marconi P. Development and application of replication incompetent HSV-1-based vectors. Gene Ther 2005;12:98-102.
|
| 62. | Goins WF, Goss JR, Chancellor MB, de Groat WC, Glorioso JC, Yoshimura N. Herpes simplex virus vectormediated gene delivery for the treatment of lower urinary tract pain. Gene Ther 2009;16:558-69.
|
| 63. | Wolfe D, Mata M, Fink DJ. A human trial of HSVmediated gene transfer for the treatment of chronic pain. Gene Ther 2009;16:455-60.
|
| 64. | Goss JR, Harley CF, Mata M, O'Malley ME, Goins WF, Hu X, et al. Herpes vectormediated expression of proenkephalin reduces bone cancer pain. Ann Neurol 2002;52:662-5.
|
| 65. | Goss JR, Mata M, Goins WF, Wu HH, Glorioso JC, Fink DJ. Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion. Gene Ther 2001;8:551-6.
|
| 66. | Lachmann RH, Efstathiou S. The use of Herpes simolex virus-based vectors for gene delivery to the nervous system. Mol Med Today 1997;3:404-11.
|
| 67. | Federici T, Kutner R, Zhang XY, Kuroda H, Tordo N, Boulis NM, et al. Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer. Genet Vaccines Ther 2009;7:1-9.
|
| 68. | Cockrell AS, Kafri T. Gene delivery by lentivirus vectors. Mol Biotechnol 2007;36:184-204.
|
| 69. | Kafri T. Gene delivery by lentivirus vectors an overview. Methods Mol Biol 2004;246:367-90.
|
| 70. | Balaggan KS, Ali RR. Ocular gene delivery using lentiviral vectors. Gene Ther 2012;19:145-53.
|
| 71. | Wong LF, Goodhead L, Prat C, Mitrophanous KA, Kingsman SM, Mazarakis ND. Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications. Human Gen Ther 2006;17:1-9.
|
| 72. | Azzouz M, Martin-Rendon E, Barber RD, Mitrophanous KA, Carter EE, Rohll JB, et al. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. J Neurosci 2002;22:10302-12.
|
| 73. | Betchen SA, Kaplitt M. Future and current surgical therapies in Parkinson's disease. Curr Opin Neurol 2003;16:487-93.
|
| 74. | Blesch A, Ynski MH. Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J 2004;45:28-31.
|
| 75. | Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 2005;8:1343-9.
|
| 76. | Moroziewicz D, Kaufman HL. Gene therapy with poxvirus vectors. Curr Opin Mol Ther 2005;7:317-25.
|
| 77. | Gómez CE, Nájera JL, Krupa M, Esteban M. The poxvirus vectors MVA and NYVAC as gene delivery systems for vaccination against infectious diseases and cancer. Curr Gene Ther 2008;8:97-120.
|
| 78. | Pastoret PP, Vanderplasschen A. Poxviruses as vaccine vectors. Comp Immunol Microbiol Infect Dis 2003;26:343-55.
|
| 79. | Moss B. Genetically engineered poxviruses for recombinant gene expression, vaccination and safety. Proc Natl Acad Sci U S A 1996;93:11341-8.
|
| 80. | McAneny D, Ryan CA, Beazley RM, Kaufman HL. Results of a phase I trial of a recombinant vaccinia virus that expresses carcinoembryonic antigen in patients with advanced colorectal cancer. Ann Surg Oncol 1996;3:395-500.
|
| 81. | Borysiewicz LK, Fiander A, Nimako M, Man S, Wilkinson GW, Westmoreland D, et al. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet 1996;347:1523-7.
|
| 82. | Mecsas J, Sugden B. Replication of plasmids derived from bovine papilloma virus type 1 and Epstein-Barr virus in cell in culture. Annu Rev Cell Biol 1987;3:87-108.
|
| 83. | Kishida T, Shin-Ya M, Imanishi J, Mazda O. Dept. of Microbiol., Kyoto Prefectural Univ. of Medicine Application of EBV-based artificial chromosome to genetic engineering of mammalian cells and tissues. Micro Nano Mechatron Hum Sci 2005;7-9:133-8.
|
| 84. | Hirai H, Satoh E, Osawa M, Inaba T, Shimazaki C, Kinoshita S, et al. Use of EBV-based vector/ HVJ-liposome complex vector for targeted gene therapy of EBV-associated neoplasms. Biochem Biophys Res Commun 1997;241:112-8.
|
| 85. | Robertson ES, Ooka T, Kieff ED. Epstein-Barr virus vectors for gene delivery to B lymphocytes. Proc Natl Acad Sci U S A. 1996;93:11334-40.
|
| 86. | Audouny SA, Deleij LF, Hoekstra D, Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm Res 2002;19:1599-6005.
|
| 87. | Varga CM, Hong K, Lanf Furburger DA. Quantitative analysis of synthesis gene delivery vector design properties. Mol Ther 2001;4:438-46.
|
| 88. | Wolff JA, Ludtke JJ, Acsadi G, Williams P, Jani A. Long term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum Mol Genet 1992;1:363-9.
|
| 89. | Knapp JE, Liu D. Hydrodynamic delivery of DNA. Methods Mol Biol 2004;245:245-50.
|
| 90. | Herweijer H, Wolff JA. Progress and prospects: Naked DNA gene transfer and therapy. Gen Ther 2003;10:453-8.
|
| 91. | Yang NS, Burkhorder J, Roberts B, Martinell B, McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990;87:9568-72.
|
| 92. | Klein TM, Arentzen R, Lewis PA, Fitzpatrick McElligoutt S. Transformation of microbes, plants and animals by particle bombardment. Biotechnology 1992;10:286-91.
|
| 93. | Cheng L, Ziegelhoffer PR, Yang NS. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci USA 1993;90:4455-9.
|
| 94. | Mahvi DM, Sheehy MJ, Yang NS. DNA cancer vaccines: A gene gun approach. Immunol Cell Biol 1997;75:456-60.
|
| 95. | Heller LC, Ugen K, Heller R. Electroporation for targeted gene transfer. Expert Opin Drug Deliv 2005;2:255-68.
|
| 96. | Lurquin PF. Gene transfer by electroporation. Mol Biotechnol 1997;7:5-35.
|
| 97. | Potter H, Cooke SW. Gene transfer into adherent cells growing on microbeads. In: Change DC, editor. Guide to electroporation and electrofusion. San Diego, CA, USA: Academic Press; 1992. p. 201-8.
|
| 98. | Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH. Gene transferin to mouse lyoma cells by electroporation in high electric fields. EMBOJ 1982;1:841-5.
|
| 99. | Dean DA, Machado Aranda D, Blair Parks K, Yeldandi AV, Young JL. Electroporation as a method for high level nonviral gene transfer to the lung. Gene Ther 2003;10:1608-15.
|
| 100. | Mc Mahon JM, Wells DJ. Electroporation for gene transfer to skeletal muscles: Current status. Biol Drugs 2004;18:155-65.
|
| 101. | Hatada S, Nikkuni K, Bentley SA, Kirby S, Smithies O. Gene correction in hematopoietic progenitor cells by homologous recombination. Proc Natl Acad Sci USA 2000;97:13807-11.
|
| 102. | Hofmann GA, Dev SB, Nanda GS, Rabusssay D. Electroporation therapy of solid tumors. Crit Rev Ther Drug Carrier Syst 1999;16:523-69.
|
| 103. | Gissel H, Clausen T. Excitation -induced Ca influx and skeletal muscle cell damage. Acta Physiol Scand 2001;171:327-34.
|
| 104. | Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999;10:1258-66.
|
| 105. | Miao CH, Ye X, Thompson AR. High level factor VIII gene expression in vivo achieved by nonviral liver-specific gene therapy vectors. Hum Gen Ther 2003;14:1297-305.
|
| 106. | Jiang J, Yamato E, Miyazaki J. Intravenous delivery of naked plasmid DNA for in vivo cytokine expression. Biochem Biophys Res Commun 2001;289:1088-92.
|
| 107. | Maruyama H, Higuchi N, Kameda S, Miyazaki J, Gejyo F. Rat liver targeted naked plasmid DNA transfer by tail vein injection. Mol Biotechnol 2004;26:165-72.
|
| 108. | Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y. Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth. Hepatology 2001;33:848-59.
|
| 109. | Kim HJ, Greeenleaf JF, Kinnick RR, Bronk JT, Bolander ME. Ultrasound-mediated transfection of mammalian cells. Hum Gene Ther 1996;7:1339-46.
|
| 110. | Liang HD, Lu QL, Xue SA, Halliwell M, Kodama T, Cosgrove DO, et al. Optimisation of ultrasound mediated gene transfer (sonoporation) in skeletal muscle cells. Ultrasound Med Biol 2004;30:1523-9.
|
| 111. | Plank C, Schillinger U, Scherer F, Bergemann C, Rémy JS, Krötz F, et al. The magnetofection method: Using magnetic force to enhance gene delivery. Biol Chem 2003;384:737-47.
|
| 112. | Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Krüger A, et al. Magnetofection: Enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 2002;9:102-9.
|
| 113. | Plank C, Anton M, Rudolph C, Rosenecker J, Krötz F. Enhancing and targeting nucleic acid delivery by magnetic force. Exp Opin Biol Ther 2003;3:745-58.
|
| 114. | Mair L, Ford K, Alam MR, Kole R, Fisher M, Superfine R. et al. Size-Uniform 200 nm Particles: Fabrication and Application to Magnetofection. J Biomed Nanotechnol 2009;5:182-91.
|
| 115. | Liu D, Ren T, Gao X. Cationic transfection lipids. Curr Med Chem 2003;10:1735-7.
|
| 116. | Zhang S, Xu Y, Wang B, Qiao W, Liu D, Li Z. Cationic compounds used in lipoplexes and polyplexes for gene delivery. J Controlled Release 2004;100:165-80.
|
| 117. | Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006;58:32-45.
|
| 118. | Boeckle S, Wagner E. Optimizing targeted gene delivery: Chemical Modification of viral vectors and synthesis of artificial virus vector systems. AAPS J 2006;8:Article 83.
|
| 119. | Kim TG, Kang SY, Kang JH, Cho MY, Kim JI, Kim SH, et al. Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates. Bioconjug Chem 2004;15:326-32.
|
| 120. | Wolschek MF, Thallinger C, Kursa M, Rössler V, Allen M, Lichtenberger C, et al. Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology 2002;36:1106-14.
|
| 121. | Xu L, Pirollo KF, Tang WH, Rait A, Chang EH. Transferrin-liposome-mediated systemic p53 gene therapy in combination with radiation results in regression of human head and neck cancer xenografts. Hum Gene Ther 1999;10:2941-52.
|
| 122. | Chiu SJ, Ueno NT, Lee RJ. Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine. J Control Release 2004;97:357-69.
|
| 123. | Zhang Y, Zhang YF, Bryant J, Charles A, Boado RJ, Pardridge WM. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin Cancer Res 2004;10:3667-77.
|
| 124. | Hood JD, Bednarski M, Frausto R, Guccione S, Reisfeld RA, Xiang R, et al. Tumor regression by targeted gene delivery to the neovasculature. Science 2002;296:2404-7.
|
| 125. | Plank C, Zatloukal K, Cotton M, Mechtler K, Wagner E. Gene transfer into hepatocytes using asialoglycoprotein receptor-mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand1. Bioconjug Chem 1992;3:533-9.
|
| 126. | Ziandy AG, Ferkol T, Dawson DV, Perlmutter DH, Davis PB. Chain length of the polylysine in receptor-targeted gene transfer complexes affects duration of reporter gene expression both in vitro and in vivo. 1999;274:4908-16.
|
| 127. | Hofland HE, Masson C, Iginla S, Osetinsky I, Reddy JA, Leamon CP, et al. Folate-targeted gene transfer in vivo. Mol Ther 2002;5:739-44.
|
| 128. | Son KK, Tkaeh D, Hall KJ. Efficient in vivo gene delivery by the negatively charged complexes of cationic liposome and plasmid. DNA Biochem Biophys Acta 2000;1468:6-10.
|
| 129. | Mastrobattista E, Koning GA, van Bloois L, Filipe AC, Jiskoot W, Storm G. Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins. J Biol Chem 2002;277:27135-43.
|
| 130. | Schnyder A, Huwyler J. Drug transport to brain with targeted liposomes. NeuroRx 2005;2:99-107.
|
| 131. | Immordino ML, Dosio F, Cattel L. Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomed 2006;1:297-315.
|
| 132. | Chen C, Han D, Cai C, Tang X. An overview of liposome lyophilization and its future potential. J Control Release 2010;142:299-311.
|
| 133. | Stenekes RJ, Loebis AE, Fernandes CM, Crommelin DJ, Hennink WE. Controlled release of liposomes from biodegradable dextran microspheres: A novel delivery concept. Pharm Res 2000;17:690-5.
|
| 134. | Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, et al. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987;84:7413-7.
|
| 135. | Cullis PR, Hope MJ, Tilcock CP. Lipid polymorphism and the roles of lipids in membranes. Chem Phys Lipds 1986;40:127-44.
|
| 136. | Wrobel I, Collins D. Fusion of cationic liposomes with mammalian cells occurs after endocytosis. Biochem Biophys Acta 1995;1235:296-304.
|
| 137. | Schwartz B, Benoist C, Abdallah B, Scherman D, Behr JP, Demeneix BA. Liposopermine-based gene transfer into the newborn mous brain is optimized by a low lipospermine DNA charge ratio. Hum Gene Ther 1995;6:1515-24.
|
| 138. | Liu F, Qi H, Huang L. Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA. Gene Ther 1997;4:517-23.
|
| 139. | Yang JP, Huang L. Overcoming the inhibitory effect of serum on lipofection by increasing the charge ratio of cationic liposome to DNA. Gene Ther 1995;92:1744-1748.
|
| 140. | Felgner JH, Kumar R, Sridhar CN, Wheeler CJ, Tsai YJ, Border R, et al. Enhanced gene delivery and mechanism studies with a novol series of cationic lipid formulations. J Biol Chem 1994;269:2550-61.
|
| 141. | Alton EW, Middleton PG, Caplen NJ, Smith SN, Steel DM, Munkonge FM, et al. Non-invasive liposome mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat Gent 1993;5:135-42.
|
| 142. | McQuillin A, Murray KD, Etheridge CJ, Stewart L, Cooper RG, Brett PM, et al. Optimization of liposome mediated transfection of a neuronal cell line. 1997;8:135-42.
|
| 143. | Fife K, Bower M, Cooper RG. Endothelial cell transfection with cationic liposomes and herpes simolex-thymidine kinase mediated killing. Gen Ther 1998;5:614-20.
|
| 144. | Birchall JC, Kellawy IW, Mills SN. Physicochemical characterization and transfection efficiency of lipid-based gene delivery complexes. Int J Pharm 1999;183:195-207.
|
| 145. | Stribling R, Brunette E, Liggitt D, Gaensler K, Debs R. Aerosol gene delivery in vivo. Proc Natl Acad Sci USA 1992;89:11277-81.
|
| 146. | Caplen NJ, Alton EW, Middleton PG, Dorin JR, Stevenson BJ, Gao X, et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med 1995;1:39-46.
|
| 147. | Alton EW, Stern M, Farley R, Jaffe A, Chadwick SL, Phillips J, et al. Cationic lipid mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: A double blind placebo-controlled trial. Lancet 1999;353:947-54.
|
| 148. | Zhu N, Liggitt D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993;261:209-11.
|
| 149. | Rogy MA, Auffenberg T, Espat NJ, Philip R, Remick D, Wollenberg GK, et al. Human tumor necrosis factor receptor(p55) and interleukin 10 gene transfer in the mouse reduces mortality to the lethal endotoxemia and also attenuates local inflammatory responses. J Exp Med 1995;181:2289-93.
|
| 150. | Murray KD, McQuillin A, Stewart L, Etheridge CJ, Cooper RG, Miller AD, et al. Cationic liposome mediated DNA transfection in organotype explant cultures of the ventral mesencephalon. Gene Ther 1999;6:190-7.
|
| 151. | Thierry AR, Lunardiskander Y, Bryant JL, Rabinovich P, Gallo RC, Mahan LC. Systemic gene therapy: Biodistribution and long term expression of a transgene in mice. Proc Natl Acad Sci USA 1995;92:9742-6.
|
| 152. | Immordino ML, Dosio F, Cattel L. Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomed 2006;1:297-315.
|
| 153. | Bharali DJ, Khalil M, Gurbuz M, Simone TM, Mousa SA. Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers. International. J Nanomed 2009;4:1-7.
|
| 154. | Kim ES, Lu C, Khuri FR, Tonda M, Glisson BS, Liu D, et al. A phase II study of STEALTH cisplatin (SPI-77) in patients with advanced nonsmall cell lung cancer. Lung Cancer 2001;34:427-32.
|
| 155. | Goyal P, Goyal K, Kumar SG, Singh A, Katare OP, Mishra DN. Liposomal drug delivery systems-clinical applications. Acta Pharm 2005;55:1-25.
|
| 156. | Pradhan P, Giri J, Rieken F, Koch C, Mykhaylyk O, Döblinger M, et al. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy. J Control Release 2010;1:108-21.
|
| 157. | Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenamine. Proc Natl Acad Sci USA 1995;92:7297-301.
|
| 158. | Martin ME, Rice KG. Peptide-guided Gene Delivery. AAPS J 2007;9:Article 3.
|
| 159. | Wolfert MA, Saymour LW. Atomic force microscopic analysis of the influence of the molecular weight of poly(L)lysine on the size of polyelectrolyte complexes formed with DNA. Gen Ther 1996;3:269-73.
|
| 160. | El-Aneed A. An overview of current delivery systems in cancer gene therapy. J Control Release 2004;94:1-14.
|
| 161. | Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997;4:823-32.
|
| 162. | Wadhwa MS, Collard WT, Adami RC, McKenzie DL, Rice KG. Peptide-mediated gene delivery: Influence of peptide structure on gene expression. Bioconjug Chem 1997;8:81-8.
|
| 163. | McKenzie DL, Collard WT, Rice KG. Comparative gene transfer efficiency of low molecular weight polylysine DNA-condensing peptides. J Pept Res 1999;54:311-8.
|
| 164. | Adami RC, Collard WT, Gupta SA, Kwok KY, Bonadio J, Rice KG. Stability of peptide-condensed Plasmid DNA formulations. J Pharm Sci 1998;87:678-83.
|
| 165. | Plank C, Tang MX, Wolfe AR, Szoka FC. Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther 1999;10:319-32 .
|
| 166. | Wightman L, Kircheis R, Rössler V, Carotta S, Ruzicka R, Kursa M, et al. Different behavior of the branched and linear polyethylenamine for gene delivery in vitro and in vivo. J Gene Med 2000;3:362-72.
|
| 167. | Zanta MA, Boussif O, Adib A, Behr JP. In vitro gene delivery to hepatocytes with galactosylenimine. Bioconjugate Chem 1997;8:839-44.
|
| 168. | Kircheis R, Kichler A, Wallner G, Kursa M, Ogris M, Felzmann T, et al. Coupling of cell binding ligands to polyethylenimine for targeted gene delivery. Gene Ther 1997;4:409-18.
|
| 169. | Erbacher P, Remy JS, Behr JP. Gene transfer with synthetic virus like particles via the integrin mediated endocytosis pathway. Gene Ther 1999;6:138-45.
|
| 170. | Tang MX, Szoka FC. The influence of polymer structure on the interaction of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997;4:823-32.
|
| 171. | Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials 2003;24:1121-31.
|
| 172. | Fischer D, Bieber T, Li Y, Elasser HP, Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenamine: Effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999;16:1273-9.
|
| 173. | Lim YB, Han SO, Kong HU. Biodegradable polyester, poly[alpha-(4-aminobutyl)-L-glycolic acid], as anon-toxic gene carrier. Pharm Res 2000;7:811-6.
|
| 174. | Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycationics. Biochemistry 1996;35:1027-36.
|
| 175. | Lee RJ, Huang L. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J Biol Chem 1996;271:8481-7.
|
| 176. | Lee LK, Williams CL, Devore D, Roth CM. Poly (eropylacrylicacid) enhances cationic lipid-mediated delivery of antisense oligonucleotides. Biomacromolecules 2006;7:1502-8.
|
| 177. | Maguire AM, Simonelli F, Pierce EA, Pugh EN, Mingozzi F, Bennicelli J, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008;358:2240-8.
|
| 178. | Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, et al. Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration Molecular therapy. J Am Soc Gene Ther 2010;18:643-50.
|
| 179. | Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL, et al. Vision 1 year after gene therapy for Leber's congenital amaurosis. N Engl J Med 2009;361:725-7.
|
| 180. | Cartier N, Aubourg P. Hematopoietic Stem Cell Transplantation and Hematopoietic Stem Cell Gene Therapy in X-Linked Adrenoleukodystrophy. Brain Pathol 2010;20:857-862.
|
| 181. | LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, et al. AAV2-GAD gene therapy for advanced Parkinson's disease: A double-blind, sham-surgery controlled, randomised trial. Lancet Neurol 2011;10:309-19.
|
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|
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|
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GENE THERAPY – THE FUTURE OF MEDICINE |
|
| o Krishnasai Reddy, S P Srinivas Nayak, Puvvula Vijaya Durga, Swapna Kannabathula, Tarun Kumar Upadhyay | | PARIPEX INDIAN JOURNAL OF RESEARCH. 2022; : 73 | | [Pubmed] | [DOI] | | | 49 |
Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems |
|
| DaniyahA Almarghalani, SaiH.S. Boddu, Mohammad Ali, Akhila Kondaka, Devin Ta, RayyanA Shah, ZahoorA Shah | | Neural Regeneration Research. 2022; 17(8): 1717 | | [Pubmed] | [DOI] | | | 50 |
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|
| GhassaqT Alubaidi, ShathaM Hasan | | Medical Journal of Babylon. 2022; 19(3): 318 | | [Pubmed] | [DOI] | | | 51 |
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|
| Jia-Ying Chien, Shun-Ping Huang | | Tzu Chi Medical Journal. 2022; 34(4): 367 | | [Pubmed] | [DOI] | | | 52 |
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|
| Rajalekshmy Girishkumar Padmakumari, Caroline Diana Sherly, Rekha Mannemcherril Ramesan | | Therapeutic Delivery. 2022; 13(6): 339 | | [Pubmed] | [DOI] | | | 53 |
Nicotinic acid-based cationic vectors for efficient gene delivery to glioblastoma cells |
|
| Shireesha Manturthi, Dwaipayan Bhattacharya, Kalyani Rajesh Sakhare, Kumar Pranav Narayan, Srilakshmi V. Patri | | New Journal of Chemistry. 2022; | | [Pubmed] | [DOI] | | | 54 |
Hollow spherical nucleic acid structures based on polymer-coated phospholipid vesicles |
|
| Emi Haladjova, Maria Petrova, Iva Ugrinova, Aleksander Forys, Barbara Trzebicka, Stanislav Rangelov | | Soft Matter. 2022; | | [Pubmed] | [DOI] | | | 55 |
Delivering Multifunctional Peptide-Conjugated Gene Carrier/miRNA-218 Complexes from Monodisperse Microspheres for Bone Regeneration |
|
| Qian Li, Yuejia Deng, Xiaohua Liu | | ACS Applied Materials & Interfaces. 2022; | | [Pubmed] | [DOI] | | | 56 |
Cimetidine-Based Cationic Amphiphiles for In Vitro Gene Delivery Targetable to Colon Cancer |
|
| Shireesha Manturthi, Dwaipayan Bhattacharya, Kalyani Rajesh Sakhare, Kumar Pranav Narayan, Srilakshmi V. Patri | | ACS Omega. 2022; | | [Pubmed] | [DOI] | | | 57 |
Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner |
|
| Ibo Janssens, Diana Campillo Davó, Jasper Van den Bos, Hans De Reu, Zwi N. Berneman, Inez Wens, Nathalie Cools | | Cytotherapy. 2022; | | [Pubmed] | [DOI] | | | 58 |
Virosome, a promising delivery vehicle for siRNA delivery and its novel preparation method |
|
| Yichen Wang, Bao Li, Yucen Luo, Tianzhi Yang, Xiaoyun Zhao, Pingtian Ding | | Journal of Drug Delivery Science and Technology. 2022; : 103490 | | [Pubmed] | [DOI] | | | 59 |
Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells |
|
| Sijia Yi, Sun-Young Kim, Michael P. Vincent, Simseok A. Yuk, Sharan Bobbala, Fanfan Du, Evan Alexander Scott | | iScience. 2022; 25(7): 104555 | | [Pubmed] | [DOI] | | | 60 |
Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases |
|
| Timofei Chernega, Jaehyoung Choi, Leonardo Salmena, Ana Cristina Andreazza | | Molecular Therapy - Nucleic Acids. 2022; 30: 359 | | [Pubmed] | [DOI] | | | 61 |
Intranasal Application of Adeno-Associated Viruses: A Systematic Review |
|
| Anselm J. Gadenstaetter, Lukas Schmutzler, Dirk Grimm, Lukas D. Landegger | | Translational Research. 2022; | | [Pubmed] | [DOI] | | | 62 |
Comparison of Acoustofluidic and Static Systems for Ultrasound-Mediated Molecular Delivery to T Lymphocytes |
|
| Connor S. Centner, John T. Moore, Mary E. Baxter, Kavitha Yaddanapudi, Paula J. Bates, Jonathan A. Kopechek | | Ultrasound in Medicine & Biology. 2022; | | [Pubmed] | [DOI] | | | 63 |
Modular Adapters Utilizing Binders of Different Molecular Types Expand Cell-Targeting Options for Adenovirus Gene Delivery |
|
| Patrick C. Freitag, Fabian Brandl, Dominik Brücher, Fabian Weiss, Birgit Dreier, Andreas Plückthun | | Bioconjugate Chemistry. 2022; | | [Pubmed] | [DOI] | | | 64 |
Influence of Linker Orientation and Regulative Factor(s) in Liposomal Gene Delivery: A Molecular Level Investigation |
|
| Wahida Rahaman, Arijit Bag, Sourav Pal | | The Journal of Physical Chemistry A. 2022; | | [Pubmed] | [DOI] | | | 65 |
Nucleic Acid Delivery to the Vascular Endothelium |
|
| Melanie Reschke, Alexandra S. Piotrowski-Daspit, Jordan S. Pober, W. Mark Saltzman | | Molecular Pharmaceutics. 2022; | | [Pubmed] | [DOI] | | | 66 |
Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model |
|
| Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh | | International Journal of Biological Macromolecules. 2022; 208: 901 | | [Pubmed] | [DOI] | | | 67 |
Nucleic acid-based therapeutics for dermal wound healing |
|
| Preety Sharma, Arun Kumar, Tarun Agarwal, Asmita Deka Dey, Farnaz Dabbagh Moghaddam, Illnaz Rahimmanesh, Mahsa Ghovvati, Satar Yousefiasl, Assunta Borzacchiello, Abbas Mohammadi, Venkata Rajesh Yella, Omid Moradi, Esmaeel Sharifi | | International Journal of Biological Macromolecules. 2022; | | [Pubmed] | [DOI] | | | 68 |
Structure of micelleplexes formed between QPDMAEMA-b-PLMA amphiphilic cationic copolymer micelles and DNA of different lengths |
|
| Varvara Chrysostomou, Aleksander Forys, Barbara Trzebicka, Costas Demetzos, Stergios Pispas | | European Polymer Journal. 2022; 166: 111048 | | [Pubmed] | [DOI] | | | 69 |
Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy? |
|
| Longfei Deng, Ping Liang, Hongjuan Cui | | Genes & Diseases. 2022; | | [Pubmed] | [DOI] | | | 70 |
Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy |
|
| Hong Li, Tingli Liu, Yongchun Yang, William C. Cho, Robin J. Flynn, Majid Fasihi Harandi, Houhui Song, Xuenong Luo, Yadong Zheng | | Genes & Diseases. 2022; | | [Pubmed] | [DOI] | | | 71 |
Liposomes: An emerging carrier for targeting Alzheimer’s and Parkinson’s Diseases |
|
| Sureshbabu Ram Kumar Pandian, Kevin Kumar Vijayakumar, Sankaranarayanan Murugesan, Selvaraj Kunjiappan | | Heliyon. 2022; : e09575 | | [Pubmed] | [DOI] | | | 72 |
Innovative nonviral gene delivery strategies for engineering human mesenchymal stem cell phenotypes toward clinical applications |
|
| Andrew Hamann, Angela K Pannier | | Current Opinion in Biotechnology. 2022; 78: 102819 | | [Pubmed] | [DOI] | | | 73 |
Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines |
|
| Takashi Nakamura, Yusuke Sato, Yuma Yamada, Mahmoud M. Abd Elwakil, Seigo Kimura, Mahmoud A. Younis, Hideyoshi Harashima | | Advanced Drug Delivery Reviews. 2022; : 114417 | | [Pubmed] | [DOI] | | | 74 |
Targeting Genetic Modifiers of HBG Gene Expression in Sickle Cell Disease: The miRNA Option |
|
| Athena Starlard-Davenport, Qingqing Gu, Betty S. Pace | | Molecular Diagnosis & Therapy. 2022; | | [Pubmed] | [DOI] | | | 75 |
Chimeric antigen receptor T cell structure, its manufacturing, and related toxicities; A comprehensive review |
|
| Ubaid Ahmad, Zafran Khan, Daniya Ualiyeva, Obed Boadi Amissah, Zohaib Noor, Asaf Khan, Nasib Zaman, Marwa Khan, Ayub Khan, Babar Ali | | Advances in Cancer Biology - Metastasis. 2022; : 100035 | | [Pubmed] | [DOI] | | | 76 |
Investigating 3R In Vivo Approaches for Bio-Distribution and Efficacy Evaluation of Nucleic Acid Nanocarriers: Studies on Peptide-Mimicking Ionizable Lipid |
|
| Julia Giselbrecht, Shashank Reddy Pinnapireddy, Fatih Alioglu, Haider Sami, Daniel Sedding, Frank Erdmann, Christopher Janich, Michaela Schulz-Siegmund, Manfred Ogris, Udo Bakowsky, Andreas Langner, Jeroen Bussmann, Christian Wölk | | Small. 2022; : 2107768 | | [Pubmed] | [DOI] | | | 77 |
Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency |
|
| Daniel Hachim, Juzhi Zhao, Jash Bhankharia, Raquel Nuñez-Toldra, Liliana Brito, Hyejeong Seong, Michele Becce, Liliang Ouyang, Christopher L. Grigsby, Stuart G. Higgins, Cesare M. Terracciano, Molly M. Stevens | | Small. 2022; : 2202303 | | [Pubmed] | [DOI] | | | 78 |
Pyrrolidine-based cationic ?-peptide: a DNA-binding molecule works as a potent anti-gene agent |
|
| Habbanakuppe D. Preetham, M. Umashankara, Kothanahally S. Sharath Kumar, Shobith Rangappa, Kanchugarakoppal S. Rangappa | | Medicinal Chemistry Research. 2022; | | [Pubmed] | [DOI] | | | 79 |
Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases |
|
| Meihua Luo, Leo Kit Cheung Lee, Bo Peng, Chung Hang Jonathan Choi, Wing Yin Tong, Nicolas H. Voelcker | | Advanced Science. 2022; : 2201740 | | [Pubmed] | [DOI] | | | 80 |
Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus-Like Nanoparticles for Nucleic Acid Delivery |
|
| Poulami Jana, Krishnananda Samanta, Martin Ehlers, Elio Zellermann, Sandra Bäcker, Roland H. Stauber, Carsten Schmuck, Shirley K. Knauer | | ChemBioChem. 2022; | | [Pubmed] | [DOI] | | | 81 |
Nonviral vector system for cancer immunogene therapy |
|
| Wen Nie, Jing Chen, Bilan Wang, Xiang Gao | | MedComm – Biomaterials and Applications. 2022; 1(1) | | [Pubmed] | [DOI] | | | 82 |
Lipid Nanoparticles for Drug Delivery |
|
| Letao Xu, Xing Wang, Yun Liu, Guangze Yang, Robert J. Falconer, Chun-Xia Zhao | | Advanced NanoBiomed Research. 2021; : 2100109 | | [Pubmed] | [DOI] | | | 83 |
Caspase-3: Structure, function, and biotechnological aspects |
|
| Marzieh Asadi,Saeed Taghizadeh,Elina Kaviani,Omid Vakili,Mortaza Taheri-Anganeh,Mahshid Tahamtan,Amir Savardashtaki | | Biotechnology and Applied Biochemistry. 2021; | | [Pubmed] | [DOI] | | | 84 |
In Situ Deployment of Engineered Extracellular Vesicles into the Tumor Niche via Myeloid-Derived Suppressor Cells |
|
| Silvia Duarte-Sanmiguel, Ana Panic, Daniel J. Dodd, Ana Salazar-Puerta, Jordan T. Moore, William R. Lawrence, Kylie Nairon, Carlie Francis, Natalie Zachariah, William McCoy, Rithvik Turaga, Aleksander Skardal, William E. Carson, Natalia Higuita-Castro, Daniel Gallego-Perez | | Advanced Healthcare Materials. 2021; : 2101619 | | [Pubmed] | [DOI] | | | 85 |
Polyphenol-Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery |
|
| Yuxin Guo,Qing Sun,Fu-Gen Wu,Yunlu Dai,Xiaoyuan Chen | | Advanced Materials. 2021; : 2007356 | | [Pubmed] | [DOI] | | | 86 |
Nanoparticle-Mediated siRNA Delivery and Multifunctional Modification Strategies for Effective Cancer Therapy |
|
| Mengyao Chen,Chunyan Dong,Shuo Shi | | Advanced Materials Technologies. 2021; : 2001236 | | [Pubmed] | [DOI] | | | 87 |
Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems |
|
| Amir Ghaderpour,Zohreh Hoseinkhani,Reza Yarani,Sina Mohammadiani,Farshid Amiri,Kamran Mansouri | | Polymers for Advanced Technologies. 2021; | | [Pubmed] | [DOI] | | | 88 |
Pathogenetic Therapy of Epidermolysis Bullosa: Current State and Prospects |
|
| I. I. Ryumina,K. V. Goryunov,D. N. Silachev,Yu. A. Shevtsova,V. A. Babenko,N. M. Marycheva,Yu. Yu. Kotalevskaya,V. V. Zubkov,G. T. Zubkov | | Bulletin of Experimental Biology and Medicine. 2021; | | [Pubmed] | [DOI] | | | 89 |
Nanocarrier-delivered small interfering
RNA
for chemoresistant ovarian cancer therapy |
|
| Mingyuan Zou,Yue Du,Ruizhen Liu,Zeliang Zheng,Jian Xu | | WIREs RNA. 2021; | | [Pubmed] | [DOI] | | | 90 |
Cardiomyocyte Death and Genome-Edited Stem Cell Therapy for Ischemic Heart Disease |
|
| Hyun-Min Cho,Je-Yoel Cho | | Stem Cell Reviews and Reports. 2021; | | [Pubmed] | [DOI] | | | 91 |
Production and Use of Gesicles for Nucleic Acid Delivery |
|
| Mathias Mangion,Marc-André Robert,Igor Slivac,Rénald Gilbert,Bruno Gaillet | | Molecular Biotechnology. 2021; | | [Pubmed] | [DOI] | | | 92 |
The era of gene therapy: from preclinical development to clinical application |
|
| Nabil A. Alhakamy,David T. Curiel,Cory J. Berkland | | Drug Discovery Today. 2021; | | [Pubmed] | [DOI] | | | 93 |
Recent advances in regenerative medicine strategies for cancer treatment |
|
| Vahid Mansouri,Nima Beheshtizadeh,Maliheh Gharibshahian,Leila Sabouri,Mohammad Varzandeh,Nima Rezaei | | Biomedicine & Pharmacotherapy. 2021; 141: 111875 | | [Pubmed] | [DOI] | | | 94 |
Eukaryotic expression system complemented with expressivity of Semliki Forest Virus's RdRp and invasiveness of engineered Salmonella demonstrate promising potential for bacteria mediated gene therapy |
|
| Amal Senevirathne, Ji-Young Park, Chamith Hewawaduge, Kirthika Perumalraja, John Hwa Lee | | Biomaterials. 2021; 279: 121226 | | [Pubmed] | [DOI] | | | 95 |
Exosome-mediated delivery of RNA and DNA for gene therapy |
|
| Radha Munagala,Farrukh Aqil,Jeyaprakash Jeyabalan,Raghuram Kandimalla,Margaret Wallen,Neha Tyagi,Sarah Wilcher,Jun Yan,David J. Schultz,Wendy Spencer,Ramesh C. Gupta | | Cancer Letters. 2021; | | [Pubmed] | [DOI] | | | 96 |
Context-aware synthetic biology by controller design: Engineering the mammalian cell |
|
| Nika Shakiba,Ross D. Jones,Ron Weiss,Domitilla Del Vecchio | | Cell Systems. 2021; 12(6): 561 | | [Pubmed] | [DOI] | | | 97 |
Synthesis and validation of DOPY: a new gemini dioleylbispyridinium based amphiphile for nucleic acid transfection |
|
| Eva Aubets,Rosa Griera,Alex J. Felix,Gemma Rigol,Chiara Sikorski,David Limón,Chiara Mastrorosa,Maria Antònia Busquets,Lluïsa Pérez-García,Véronique Noé,Carlos J. Ciudad | | European Journal of Pharmaceutics and Biopharmaceutics. 2021; | | [Pubmed] | [DOI] | | | 98 |
Sphingolipid extracts enhances gene delivery of cationic lipid vesicles into retina and brain |
|
| Nuseibah AL Qtaish,Idoia Gallego,Ilia Villate- Beitia,Myriam Sainz-Ramos,Gema Martínez-Navarrete,Cristina Soto-Sánchez,Eduardo Fernández,Patricia Gálvez Martín,Tania B. Lopez-Mendez,Gustavo Puras,José Luis Pedraz | | European Journal of Pharmaceutics and Biopharmaceutics. 2021; | | [Pubmed] | [DOI] | | | 99 |
Expression, localization and metabolic function of “resurrected” human urate oxidase in human hepatocytes |
|
| Yundi Duan,Nan Jiang,Jing Chen,Jianhua Chen | | International Journal of Biological Macromolecules. 2021; | | [Pubmed] | [DOI] | | | 100 |
Amino acid derived biopolymers: Recent advances and biomedical applications |
|
| Sachchidanand Soaham Gupta,Vivek Mishra,Maumita Das Mukherjee,Praveen Saini,Kumar Rakesh Ranjan | | International Journal of Biological Macromolecules. 2021; | | [Pubmed] | [DOI] | | | 101 |
In vitro and in vivo optimization of liposomal nanoparticles based brain targeted vgf gene therapy |
|
| Sanjay Arora,Jagdish Singh | | International Journal of Pharmaceutics. 2021; 608: 121095 | | [Pubmed] | [DOI] | | | 102 |
Applications of capillary action in drug delivery |
|
| Xiaosi Li,Yue Zhao,Chao Zhao | | iScience. 2021; 24(7): 102810 | | [Pubmed] | [DOI] | | | 103 |
Polymeric Delivery of Therapeutic Nucleic Acids |
|
| Ramya Kumar,Cristiam F. Santa Chalarca,Matthew R. Bockman,Craig Van Bruggen,Christian J. Grimme,Rishad J. Dalal,Mckenna G. Hanson,Joseph K. Hexum,Theresa M. Reineke | | Chemical Reviews. 2021; | | [Pubmed] | [DOI] | | | 104 |
DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study |
|
| Yann T. Le Guen,Chantal Pichon,Philippe Guégan,Kévin Pluchon,Tanguy Haute,Sandrine Quemener,Juliette Ropars,Patrick Midoux,Tony Le Gall,Tristan Montier | | Molecular Therapy - Nucleic Acids. 2021; 24: 477 | | [Pubmed] | [DOI] | | | 105 |
Comparison of promoter, DNA vector, and cationic carrier for efficient transfection of hMSCs from multiple donors and tissue sources |
|
| Tyler Kozisek,Andrew Hamann,Luke Samuelson,Miguel Fudolig,Angela K. Pannier | | Molecular Therapy - Nucleic Acids. 2021; 26: 81 | | [Pubmed] | [DOI] | | | 106 |
Viral vectors as a promising nanotherapeutic approach against neurodegenerative disorders |
|
| Vaibhavi Srivastava,Ajit Singh,Gaurav Kumar Jain,Farhan Jalees Ahmad,Rahul Shukla,Prashant Kesharwani | | Process Biochemistry. 2021; | | [Pubmed] | [DOI] | | | 107 |
Microbial cancer therapeutics: A promising approach |
|
| Deepti Diwan,Lei Cheng,Zeba Usmani,Minaxi Sharma,Nicola Holden,Nicholas Willoughby,Neelam Sangwan,Rama Raju,Chenchen Liu,Vijai Kumar Gupta | | Seminars in Cancer Biology. 2021; | | [Pubmed] | [DOI] | | | 108 |
Nanoparticles for generating antigen-specific T cells for immunotherapy |
|
| Savannah E. Est-Witte, Natalie K. Livingston, Mary O. Omotoso, Jordan J. Green, Jonathan P. Schneck | | Seminars in Immunology. 2021; : 101541 | | [Pubmed] | [DOI] | | | 109 |
Bioactive glass: A multifunctional delivery system |
|
| Smriti Gupta,Shreyasi Majumdar,Sairam Krishnamurthy | | Journal of Controlled Release. 2021; | | [Pubmed] | [DOI] | | | 110 |
Drug delivery of pH-Sensitive Nanoparticles into the liver cancer cells |
|
| Maryam Saadat,Farid Mostafaei,Somaye Mahdinloo,Mahdieh Abdi,Fahimeh Zahednezhad,Parvin Zakeri-Milani,Hadi Valizadeh | | Journal of Drug Delivery Science and Technology. 2021; : 102557 | | [Pubmed] | [DOI] | | | 111 |
Synthesis of peptide-based DNA delivery system |
|
| Pranjal Somvanshi,Shefali Khisty | | Medicine in Novel Technology and Devices. 2021; : 100091 | | [Pubmed] | [DOI] | | | 112 |
The potential role of miRNA therapies in spinal muscle atrophy |
|
| Gayatri Gandhi,Syahril Abdullah,Agus Iwan Foead,Wendy Wai Yeng Yeo | | Journal of the Neurological Sciences. 2021; : 117485 | | [Pubmed] | [DOI] | | | 113 |
Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts |
|
| Jose Antonio Duran-Mota,Júlia Quintanas Yani,Benjamin D. Almquist,Salvador Borrós,Nuria Oliva | | ACS Biomaterials Science & Engineering. 2021; | | [Pubmed] | [DOI] | | | 114 |
A Review of Brain-Targeted Nonviral Gene-Based Therapies for the Treatment of Alzheimer’s Disease |
|
| Sanjay Arora, Divya Sharma, Buddhadev Layek, Jagdish Singh | | Molecular Pharmaceutics. 2021; | | [Pubmed] | [DOI] | | | 115 |
Two-Photon Near-Infrared AIE Luminogens as Multifunctional Gene Carriers for Cancer Theranostics |
|
| Fang Tang,Jin-Yu Liu,Cheng-Yan Wu,Ya-Xuan Liang,Zhong-Lin Lu,Ai-Xiang Ding,Ming-Di Xu | | ACS Applied Materials & Interfaces. 2021; | | [Pubmed] | [DOI] | | | 116 |
Vector engineering, strategies and targets in cancer gene therapy |
|
| Vijayata Singh,Nusrat Khan,Giridhara R. Jayandharan | | Cancer Gene Therapy. 2021; | | [Pubmed] | [DOI] | | | 117 |
Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers |
|
| Hye-Hyun Ahn,Christine Carrington,Yizong Hu,Heng-wen Liu,Christy Ng,Hwanhee Nam,Andrew Park,Catherine Stace,Will West,Hai-Quan Mao,Martin G. Pomper,Christopher G. Ullman,Il Minn | | Scientific Reports. 2021; 11(1) | | [Pubmed] | [DOI] | | | 118 |
Revisiting gene delivery to the brain: silencing and editing |
|
| João Conniot,Sepehr Talebian,Susana Simões,Lino Ferreira,João Conde | | Biomaterials Science. 2021; | | [Pubmed] | [DOI] | | | 119 |
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine |
|
| Di Wu,Jiajing Zhou,Matthew N. Creyer,Wonjun Yim,Zhong Chen,Phillip B. Messersmith,Jesse V. Jokerst | | Chemical Society Reviews. 2021; | | [Pubmed] | [DOI] | | | 120 |
Novel a-tocopherol–ferrocene conjugates for the specific delivery of transgenes in liver cancer cells under high serum conditions |
|
| Rahmat Asfiya, Bappa Maiti, Mohini Kamra, Anjali Anoop Karande, Santanu Bhattacharya | | Biomaterials Science. 2021; 9(22): 7636 | | [Pubmed] | [DOI] | | | 121 |
Nanotechnology-based therapeutic applications: in vitro and in vivo clinical studies for diabetic wound healing |
|
| Sheikh Tanzina Haque, Subbroto Kumar Saha, Md. Enamul Haque, Nirupam Biswas | | Biomaterials Science. 2021; 9(23): 7705 | | [Pubmed] | [DOI] | | | 122 |
Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery |
|
| Matthew R. Bockman,Rishad J. Dalal,Ramya Kumar,Theresa M. Reineke | | Polymer Chemistry. 2021; | | [Pubmed] | [DOI] | | | 123 |
Human-derived NLS enhance the gene transfer efficiency of chitosan |
|
| Diogo B. Bitoque,Joana Morais,Ana V. Oliveira,Raquel L. Sequeira,Sofia M. Calado,Tiago M. Fortunato,Sónia Simão,Ana M. Rosa da Costa,Gabriela A. Silva | | Bioscience Reports. 2021; 41(1) | | [Pubmed] | [DOI] | | | 124 |
Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung |
|
| Leonor de Braganca,G. John Ferguson,Jose Luis Santos,Jeremy P. Derrick | | Journal of Immunotoxicology. 2021; 18(1): 61 | | [Pubmed] | [DOI] | | | 125 |
Gene Therapy as an Emerging Therapeutic Approach to Breast Cancer: New Developments and Challenges |
|
| Motahareh Sheikh-Hosseini,Bagher Larijani,Zahra Gholipoor Kakroodi,Mahshid Shokoohi,Mohammad Moarefzadeh,Forough Azam Sayahpour,Parisa Goodarzi,Babak Arjmand | | Human Gene Therapy. 2021; | | [Pubmed] | [DOI] | | | 126 |
PnBA-b-PNIPAM-b-PDMAEA Thermo-Responsive Triblock Terpolymers and Their Quaternized Analogs as Gene and Drug Delivery Vectors |
|
| Athanasios Skandalis,Dimitrios Selianitis,Stergios Pispas | | Polymers. 2021; 13(14): 2361 | | [Pubmed] | [DOI] | | | 127 |
Room for improvement in the treatment of pancreatic cancer: Novel opportunities from gene targeted therapy |
|
| Michail Galanopoulos,Aris Doukatas,Filippos Gkeros,Nikos Viazis,Christos Liatsos | | World Journal of Gastroenterology. 2021; 27(24): 3568 | | [Pubmed] | [DOI] | | | 128 |
Transfection types, methods and strategies: a technical review |
|
| Zhi Xiong Chong,Swee Keong Yeap,Wan Yong Ho | | PeerJ. 2021; 9: e11165 | | [Pubmed] | [DOI] | | | 129 |
The Potential Benefits of Nanotechnology in Treating Alzheimer’s Disease |
|
| Tan Sook Ling,Shanthini Chandrasegaran,Low Zhi Xuan,Tong Li Suan,Elaine Elaine,Durrgashini Visva Nathan,Yam Hok Chai,Baskaran Gunasekaran,Shamala Salvamani,Yohannes Woldeamanuel | | BioMed Research International. 2021; 2021: 1 | | [Pubmed] | [DOI] | | | 130 |
Recent advances in targeted drug delivery for treatment of osteoarthritis |
|
| Shikhar Mehta,Tengfei He,Ambika G. Bajpayee | | Current Opinion in Rheumatology. 2021; 33(1): 94 | | [Pubmed] | [DOI] | | | 131 |
Low-frequency ultrasound combined with microbubbles improves gene transfection in prostate cancer cells in vitro and in vivo |
|
| Wei Zhang,Shu-liang Nan,Wen-kun Bai,Bing Hu | | Asia-Pacific Journal of Clinical Oncology. 2021; | | [Pubmed] | [DOI] | | | 132 |
Recent Advances and Challenges in Gene Delivery Mediated by Polyester-Based Nanoparticles |
|
| Anna Piperno,Maria Teresa Sciortino,Elena Giusto,Monica Montesi,Silvia Panseri,Angela Scala | | International Journal of Nanomedicine. 2021; Volume 16: 5981 | | [Pubmed] | [DOI] | | | 133 |
Gene Therapy for Prostate Cancer: A Review |
|
| Swapnil S. Talkar, Vandana B. Patravale | | Endocrine, Metabolic & Immune Disorders - Drug Targets. 2021; 21(3): 385 | | [Pubmed] | [DOI] | | | 134 |
Exploring the Role of Gene Therapy for Neurological Disorders |
|
| Nidhi Puranik, Dhananjay Yadav, Pallavi Singh Chauhan, Minseok Kwak, Jun-O Jin | | Current Gene Therapy. 2021; 21(1): 11 | | [Pubmed] | [DOI] | | | 135 |
Evaluation of the Nucleopolyhedrovirus of Anticarsia gemmatalis as a Vector for Gene Therapy in Mammals |
|
| Cintia N. Parsza, Diego L.M. Gómez, Jorge A. Simonin, Mariano Nicolás Belaich, Pablo D. Ghiringhelli | | Current Gene Therapy. 2021; 21(2): 177 | | [Pubmed] | [DOI] | | | 136 |
Liposomes: An Emerging Carrier for Brain Targetting and Delivery |
|
| Sureshbabu Ram Kumar Pandian, Kevin Kumar Vijayakumar, Murugesan Sankaran, Selvaraj Kunjiappan | | SSRN Electronic Journal. 2021; | | [Pubmed] | [DOI] | | | 137 |
Innovative Applications of Plant Viruses in Drug Targeting and Molecular Imaging- A Review |
|
| Alaa A.A. Aljabali,Mazhar S. Al Zoubi,Khalid M. Al-Batayneh,Dinesh M. Pardhi,Kamal Dua,Kaushik Pal,Murtaza M. Tambuwala | | Current Medical Imaging Formerly Current Medical Imaging Reviews. 2021; 17(4): 491 | | [Pubmed] | [DOI] | | | 138 |
Dysregulation of miRNAs in DLBCL: Causative Factor for Pathogenesis, Diagnosis and Prognosis |
|
| Mohammed Alsaadi,Muhammad Yasir Khan,Mahmood Hassan Dalhat,Salem Bahashwan,Muhammad Uzair Khan,Abdulgader Albar,Hussein Almehdar,Ishtiaq Qadri | | Diagnostics. 2021; 11(10): 1739 | | [Pubmed] | [DOI] | | | 139 |
Stabilization of Poly (ß-Amino Ester) Nanoparticles for the Efficient Intracellular Delivery of PiggyBac Transposon |
|
| Tina Rodgers,Nicolas Muzzio,Caleb Watson,Gabriela Romero | | Bioengineering. 2021; 8(2): 16 | | [Pubmed] | [DOI] | | | 140 |
Genetic modification of mesenchymal stem cells to enhance their anti-tumor efficacy |
|
| | | Asia-Pacific Journal of Oncology. 2021; : 1 | | [Pubmed] | [DOI] | | | 141 |
Non-viral Gene Therapy for Osteoarthritis |
|
| Ilona Uzieliene,Ursule Kalvaityte,Eiva Bernotiene,Ali Mobasheri | | Frontiers in Bioengineering and Biotechnology. 2021; 8 | | [Pubmed] | [DOI] | | | 142 |
Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers |
|
| Ina F. de la Fuente,Shraddha S. Sawant,Mark Q. Tolentino,Patrick M. Corrigan,Jessica L. Rouge | | Frontiers in Chemistry. 2021; 9 | | [Pubmed] | [DOI] | | | 143 |
Cell and Gene Therapy for Anemia: Hematopoietic Stem Cells and Gene Editing |
|
| Dito Anurogo,Nova Yuli Prasetyo Budi,Mai-Huong Thi Ngo,Yen-Hua Huang,Jeanne Adiwinata Pawitan | | International Journal of Molecular Sciences. 2021; 22(12): 6275 | | [Pubmed] | [DOI] | | | 144 |
PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing |
|
| Eva Aubets,Miguel Chillon,Carlos J. Ciudad,Véronique Noé | | International Journal of Molecular Sciences. 2021; 22(18): 10025 | | [Pubmed] | [DOI] | | | 145 |
Therapeutic Acellular Scaffolds for Limiting Left Ventricular Remodelling-Current Status and Future Directions |
|
| Sadia Perveen, Daniela Rossin, Emanuela Vitale, Rachele Rosso, Roberto Vanni, Caterina Cristallini, Raffaella Rastaldo, Claudia Giachino | | International Journal of Molecular Sciences. 2021; 22(23): 13054 | | [Pubmed] | [DOI] | | | 146 |
MicroRNA Delivery by Graphene-Based Complexes into Glioblastoma Cells |
|
| Marta Kutwin,Malwina Ewa Sosnowska,Barbara Strojny-Cieslak,Slawomir Jaworski,Maciej Trzaskowski,Mateusz Wierzbicki,Andre Chwalibog,Ewa Sawosz | | Molecules. 2021; 26(19): 5804 | | [Pubmed] | [DOI] | | | 147 |
Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy |
|
| Adriana Aurelia Chis,Carmen Maximiliana Dobrea,Luca-Liviu Rus,Adina Frum,Claudiu Morgovan,Anca Butuca,Maria Totan,Anca Maria Juncan,Felicia Gabriela Gligor,Anca Maria Arseniu | | Molecules. 2021; 26(19): 5976 | | [Pubmed] | [DOI] | | | 148 |
Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
|
| Julian D. Torres-Vanegas,Juan C. Cruz,Luis H. Reyes | | Pharmaceutics. 2021; 13(3): 428 | | [Pubmed] | [DOI] | | | 149 |
Drug Delivery via the Suprachoroidal Space for the Treatment of Retinal Diseases |
|
| Liron Naftali Ben Haim,Elad Moisseiev | | Pharmaceutics. 2021; 13(7): 967 | | [Pubmed] | [DOI] | | | 150 |
Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar! |
|
| Nina Bono,Federica Ponti,Diego Mantovani,Gabriele Candiani | | Pharmaceutics. 2020; 12(2): 183 | | [Pubmed] | [DOI] | | | 151 |
Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules |
|
| Rafael R. Castillo,Daniel Lozano,María Vallet-Regí | | Pharmaceutics. 2020; 12(5): 432 | | [Pubmed] | [DOI] | | | 152 |
A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids |
|
| Bhairavi Srinageshwar,Maria Florendo,Brittany Clark,Kayla Johnson,Nikolas Munro,Sarah Peruzzaro,Aaron Antcliff,Melissa Andrews,Alexander Figacz,Douglas Swanson,Gary L. Dunbar,Ajit Sharma,Julien Rossignol | | Pharmaceutics. 2020; 12(7): 619 | | [Pubmed] | [DOI] | | | 153 |
Novel Histone-Based DNA Carrier Targeting Cancer-Associated Fibroblasts |
|
| Alexey Kuzmich,Olga Rakitina,Dmitry Didych,Victor Potapov,Marina Zinovyeva,Irina Alekseenko,Eugene Sverdlov | | Polymers. 2020; 12(8): 1695 | | [Pubmed] | [DOI] | | | 154 |
Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing |
|
| Hariharan Ezhilarasu,Dinesh Vishalli,S. Thameem Dheen,Boon-Huat Bay,Dinesh Kumar Srinivasan | | Nanomaterials. 2020; 10(6): 1234 | | [Pubmed] | [DOI] | | | 155 |
Harnessing the Potential of Stem Cells for Disease Modeling: Progress and Promises |
|
| Chiara Argentati,Ilaria Tortorella,Martina Bazzucchi,Francesco Morena,Sabata Martino | | Journal of Personalized Medicine. 2020; 10(1): 8 | | [Pubmed] | [DOI] | | | 156 |
Recent Progress of Stem Cell Therapy in Cancer Treatment: Molecular Mechanisms and Potential Applications |
|
| Dinh-Toi Chu,Tiep Tien Nguyen,Nguyen Le Bao Tien,Dang-Khoa Tran,Jee-Heon Jeong,Pham Gia Anh,Vo Van Thanh,Dang Tien Truong,Thien Chu Dinh | | Cells. 2020; 9(3): 563 | | [Pubmed] | [DOI] | | | 157 |
Lipid-Mediated Insertion of Toll-Like Receptor (TLR) Ligands for Facile Immune Cell Engineering |
|
| Michael H. Zhang,Emily M. Slaby,Georgina Stephanie,Chunsong Yu,Darcy M. Watts,Haipeng Liu,Gregory L. Szeto | | Frontiers in Immunology. 2020; 11 | | [Pubmed] | [DOI] | | | 158 |
Chimeric Antigen Receptor Based Therapy as a Potential Approach in Autoimmune Diseases: How Close Are We to the Treatment? |
|
| Muhammad Sadeqi Nezhad,Alexander Seifalian,Nader Bagheri,Sajad Yaghoubi,Mohammad Hossein Karimi,Meghdad Adbollahpour-Alitappeh | | Frontiers in Immunology. 2020; 11 | | [Pubmed] | [DOI] | | | 159 |
Membrane Trafficking and Subcellular Drug Targeting Pathways |
|
| Ajay Kumar,Anas Ahmad,Akshay Vyawahare,Rehan Khan | | Frontiers in Pharmacology. 2020; 11 | | [Pubmed] | [DOI] | | | 160 |
Recent Advances in the Treatment of Sickle Cell Disease |
|
| Gabriel Salinas Cisneros,Swee L. Thein | | Frontiers in Physiology. 2020; 11 | | [Pubmed] | [DOI] | | | 161 |
A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome |
|
| Lucy S. French,Carla B. Mellough,Fred K. Chen,Livia S. Carvalho | | Frontiers in Cellular Neuroscience. 2020; 14 | | [Pubmed] | [DOI] | | | 162 |
Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock |
|
| Raygene Martier,Pavlina Konstantinova | | Frontiers in Neuroscience. 2020; 14 | | [Pubmed] | [DOI] | | | 163 |
Fluorescent PSC-Derived Cardiomyocyte Reporter Lines: Generation Approaches and Their Applications in Cardiovascular Medicine |
|
| Naeramit Sontayananon,Charles Redwood,Benjamin Davies,Katja Gehmlich | | Biology. 2020; 9(11): 402 | | [Pubmed] | [DOI] | | | 164 |
Challenges and New Therapeutic Approaches in the Management of Chronic Wounds |
|
| Hongmin Sun,Lakshmi Pulakat,David W. Anderson | | Current Drug Targets. 2020; 21(12): 1264 | | [Pubmed] | [DOI] | | | 165 |
Viral and Nonviral Transfer of Genetic Materials to Adipose Tissues: Toward a Gold Standard Approach |
|
| Steven M. Romanelli,Ormond A. MacDougald | | Diabetes. 2020; 69(12): 2581 | | [Pubmed] | [DOI] | | | 166 |
Stepwise Development of Biomimetic Chimeric Peptides for Gene Delivery |
|
| Roya Cheraghi,Mahboobeh Nazari,Mohsen Alipour,Saman Hosseinkhani | | Protein & Peptide Letters. 2020; 27(8): 698 | | [Pubmed] | [DOI] | | | 167 |
High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells |
|
| Tyler Kozisek,Andrew Hamann,Albert Nguyen,Michael Miller,Sarah Plautz,Angela K. Pannier | | Journal of Biological Engineering. 2020; 14(1) | | [Pubmed] | [DOI] | | | 168 |
Strategies in DNA vaccine for melanoma cancer |
|
| Tayebeh Rezaei,Elham Davoudian,Saeed Khalili,Mohammad Amini,Maryam Hejazi,Miguel Guardia,Ahad Mokhtarzadeh | | Pigment Cell & Melanoma Research. 2020; | | [Pubmed] | [DOI] | | | 169 |
Pancreatic Adenocarcinoma: Unconventional Approaches for an Unconventional Disease |
|
| Christopher Gromisch,Motaz Qadan,Mariana Albuquerque Machado,Kebin Liu,Yolonda Colson,Mark W. Grinstaff | | Cancer Research. 2020; 80(16): 3179 | | [Pubmed] | [DOI] | | | 170 |
Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration |
|
| Yuanqiang Dong,Yuan Li,Chuan Zhang,Haibin Chen,Lijia Liu,Simeng Chen | | Stem Cell Research & Therapy. 2020; 11(1) | | [Pubmed] | [DOI] | | | 171 |
Lipoplex-based targeted gene therapy for the suppression of tumours with VEGFR expression by producing anti-angiogenic molecules |
|
| Shu-Yi Ho,Pin-Rong Chen,Chia-Hung Chen,Nu-Man Tsai,Yu-Hsin Lin,Chen-Si Lin,Cheng-Hsun Chuang,Xiao-Fan Huang,Yi-Lin Chan,Yen-Ku Liu,Chen-Han Chung,Shun-Long Weng,Kuang-Wen Liao | | Journal of Nanobiotechnology. 2020; 18(1) | | [Pubmed] | [DOI] | | | 172 |
Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles |
|
| Ozlem Unal,Yunus Akkoc,Muhammed Kocak,Esra Nalbat,Asiye Isin Dogan-Ekici,Havva Yagci Acar,Devrim Gozuacik | | Journal of Nanobiotechnology. 2020; 18(1) | | [Pubmed] | [DOI] | | | 173 |
Highlight article: Screening a chemically defined extracellular matrix mimetic substrate library to identify substrates that enhance substrate-mediated transfection |
|
| Andrew Hamann,Alvin K Thomas,Tyler Kozisek,Eric Farris,Steffen Lück,Yixin Zhang,Angela K Pannier | | Experimental Biology and Medicine. 2020; 245(7): 606 | | [Pubmed] | [DOI] | | | 174 |
Engineering of HN3 increases the tumor targeting specificity of exosomes and upgrade the anti-tumor effect of sorafenib on HuH-7 cells |
|
| Cong He,Doulathunnisa Jaffar Ali,Yumin Li,Yanliang Zhu,Bo Sun,Zhongdang Xiao | | PeerJ. 2020; 8: e9524 | | [Pubmed] | [DOI] | | | 175 |
A molecular view on the escape of lipoplexed DNA from the endosome |
|
| Bart MH Bruininks,Paulo CT Souza,Helgi Ingolfsson,Siewert J Marrink | | eLife. 2020; 9 | | [Pubmed] | [DOI] | | | 176 |
Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines |
|
| Giulia Anderluzzi,Gustavo Lou,Simona Gallorini,Michela Brazzoli,Russell Johnson,Derek T. O’Hagan,Barbara C. Baudner,Yvonne Perrie | | Vaccines. 2020; 8(2): 212 | | [Pubmed] | [DOI] | | | 177 |
Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy |
|
| Gayathri Kandasamy,Elena N Danilovtseva,Vadim V Annenkov,Uma Maheswari Krishnan | | Beilstein Journal of Nanotechnology. 2020; 11: 354 | | [Pubmed] | [DOI] | | | 178 |
The Role of Angiogenic Inducing microRNAs in Vascular Tissue Engineering |
|
| May-Hui Ding,Eloy G. Lozoya,Rene Rico,Sue Anne Chew | | Tissue Engineering Part A. 2020; | | [Pubmed] | [DOI] | | | 179 |
Gene Therapy and immunotherapy as promising strategies to combat Huntington’s Disease associated neurodegeneration: Emphasis on recent updates and future perspectives |
|
| Sumit Jamwal,John D Elsworth,Vikrant Rahi,Puneet Kumar | | Expert Review of Neurotherapeutics. 2020; | | [Pubmed] | [DOI] | | | 180 |
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities |
|
| Johan Karlsson,Kelly R. Rhodes,Jordan J. Green,Stephany Y. Tzeng | | Expert Opinion on Drug Delivery. 2020; : 1 | | [Pubmed] | [DOI] | | | 181 |
A self-assembling amphiphilic peptide nanoparticle for the efficient entrapment of DNA cargoes up to 100 nucleotides in length |
|
| Shabnam Tarvirdipour,Cora-Ann Schoenenberger,Yaakov Benenson,Cornelia G. Palivan | | Soft Matter. 2020; | | [Pubmed] | [DOI] | | | 182 |
3-Hydroxyhexanoate-based polycationic nanoparticle system for delivering reprogramming factors |
|
| Hanife Sevgi Varli,Funda Alkan,Fatma Ceren Kirmizitas,Murat Demirbilek,Nelisa Türkoglu Laçin | | Journal of Microencapsulation. 2020; 37(4): 332 | | [Pubmed] | [DOI] | | | 183 |
The non-viral vectors and main methods of loading siRNA onto the titanium implants and their application |
|
| Liangrui Chen,Mingxuan Bai,Ruiyu Du,Hao Wang,Yi Deng,Anqi Xiao,Xueqi Gan | | Journal of Biomaterials Science, Polymer Edition. 2020; : 1 | | [Pubmed] | [DOI] | | | 184 |
Polymeric nano-carriers for on-demand delivery of genes via specific responses to stimuli |
|
| Khan Muhammad,Jing Zhao,Bin Gao,Yakai Feng | | Journal of Materials Chemistry B. 2020; | | [Pubmed] | [DOI] | | | 185 |
Immortalisation of primary human alveolar epithelial lung cells using a non-viral vector to study respiratory bioreactivity in vitro |
|
| Alberto Katsumiti,Pakatip Ruenraroengsak,Miren P. Cajaraville,Andrew J. Thorley,Teresa D. Tetley | | Scientific Reports. 2020; 10(1) | | [Pubmed] | [DOI] | | | 186 |
Laser-assisted Delivery of Molecules in Fungal Cells |
|
| Erin McGraw,Radini Himashini Dissanayaka,John Vaughan,Nitish Kunte,German Mills,Guillaume Marc Laurent,L. Adriana Avila | | ACS Applied Bio Materials. 2020; | | [Pubmed] | [DOI] | | | 187 |
GLUT-1: An Effective Target To Deliver Brain-Derived Neurotrophic Factor Gene Across the Blood Brain Barrier |
|
| Sanjay Arora,Divya Sharma,Jagdish Singh | | ACS Chemical Neuroscience. 2020; | | [Pubmed] | [DOI] | | | 188 |
Gene based nanocarrier delivery for the treatment of hepatocellular carcinoma |
|
| Rajinikanth siddalingam,Payal Deepak,Sunita Thakur,Sneha Anand,Shweta Jaiswal,Balasubramaniam Jagdish | | Journal of Drug Delivery Science and Technology. 2020; : 101837 | | [Pubmed] | [DOI] | | | 189 |
Non-viral delivery systems of DNA into stem cells: promising and multifarious actions for regenerative medicine |
|
| Mahboob Morshed,Anwarul Hasan,Majid Sharifi,Mohammad Mahdi Nejadi Babadaei,Samir Haj Bloukh,Mohammad Ariful Islam,Ezharul Hoque Chowdhury,Mojtaba Falahati | | Journal of Drug Delivery Science and Technology. 2020; : 101861 | | [Pubmed] | [DOI] | | | 190 |
Nanocarrier centered therapeutic approaches: Recent developments with insight towards the future in the management of lung cancer |
|
| Jigar D. Vanza,Rashmin B. Patel,Mrunali R. Patel | | Journal of Drug Delivery Science and Technology. 2020; : 102070 | | [Pubmed] | [DOI] | | | 191 |
Evaluation of dendronized gold nanoparticles as siRNAs carriers into cancer cells |
|
| Elzbieta Pedziwiatr-Werbicka,Michal Gorzkiewicz,Sylwia Michlewska,Maksim Ionov,Dzmitry Shcharbin,Barbara Klajnert-Maculewicz,Cornelia E. Peña-González,Javier Sánchez-Nieves,Rafael Gómez,F. Javier de la Mata,Maria Bryszewska | | Journal of Molecular Liquids. 2020; : 114726 | | [Pubmed] | [DOI] | | | 192 |
An Update on the Toxicity of Cyanogenic Glycosides Bioactive Compounds: Possible Clinical Application in Targeted Cancer Therapy |
|
| Bashir Mosayyebi,Mahsa Imani,Leila Mohammadi,Abolfazl Akbarzadeh,Nosratollah Zarghami,Mahdi Edalati,Effat Alizadeh,Mohammad Rahmati | | Materials Chemistry and Physics. 2020; : 122841 | | [Pubmed] | [DOI] | | | 193 |
Efficient Nonviral Stable Transgenesis Mediated by Retroviral Integrase |
|
| Chang-Ying Chiang,Gloria Denise Ligunas,Wei-Chun Chin,Chih-Wen Ni | | Molecular Therapy - Methods & Clinical Development. 2020; 17: 1061 | | [Pubmed] | [DOI] | | | 194 |
Glucocorticoid Priming of Nonviral Gene Delivery to hMSCs Increases Transfection by Reducing Induced Stresses |
|
| Andrew Hamann,Tyler Kozisek,Kelly Broad,Angela K. Pannier | | Molecular Therapy - Methods & Clinical Development. 2020; 18: 713 | | [Pubmed] | [DOI] | | | 195 |
Design and Validation of Liposomal ApoE2 Gene Delivery System to Evade Blood–Brain Barrier for Effective Treatment of Alzheimer’s Disease |
|
| Sanjay Arora,Buddhadev Layek,Jagdish Singh | | Molecular Pharmaceutics. 2020; | | [Pubmed] | [DOI] | | | 196 |
In Vitro Assessment of Core-Shell Micellar Nanostructures of Amphiphilic Cationic Polymer-Peptide Conjugates as Efficient Gene and Drug Carriers |
|
| Charu Garg,Ayushi Priyam,Pradeep Kumar,Ashwani Kumar Sharma,Alka Gupta | | Journal of Pharmaceutical Sciences. 2020; | | [Pubmed] | [DOI] | | | 197 |
Gene expressing human artificial chromosome vectors: Advantages and challenges for gene therapy |
|
| Daniela Moralli,Zoia L. Monaco | | Experimental Cell Research. 2020; : 111931 | | [Pubmed] | [DOI] | | | 198 |
Nanomedicine in osteosarcoma therapy: Micelleplexes for delivery of nucleic acids and drugs toward osteosarcoma-targeted therapies |
|
| Miguel Pereira-Silva,Carmen Alvarez-Lorenzo,Angel Concheiro,Ana Cláudia Santos,Francisco Veiga,Ana Figueiras | | European Journal of Pharmaceutics and Biopharmaceutics. 2020; 148: 88 | | [Pubmed] | [DOI] | | | 199 |
Poly (ß-amino esters) based potential drug delivery and targeting polymer; an overview and perspectives (review) |
|
| Sajid Iqbal,Ying Qu,Zhonghua Dong,Jianxiong Zhao,Abdur Rauf Khan,Shams Rehman,Zhongxi Zhao | | European Polymer Journal. 2020; 141: 110097 | | [Pubmed] | [DOI] | | | 200 |
Association of miR-760 with cancer: an overview |
|
| Monika Kaushik Siddharth Manvati,Juveria Khan,Neeraj Verma,Pawan K. Dhar | | Gene. 2020; : 144648 | | [Pubmed] | [DOI] | | | 201 |
Review on mechanistic strategy of gene therapy in the treatment of disease |
|
| Sulaiman M. Alnasser | | Gene. 2020; : 145246 | | [Pubmed] | [DOI] | | | 202 |
Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives |
|
| Somayeh Mahdinloo,Seyed Hossein Kiaie,Ala Amiri,Salar Hemmati,Hadi Valizadeh,Parvin Zakeri-Milani | | Acta Pharmaceutica Sinica B. 2020; | | [Pubmed] | [DOI] | | | 203 |
In situ Bone Tissue Engineering using Gene Delivery Nanocomplexes |
|
| Atefeh Malek-Khatabi,Hamid Akbari Javar,Erfan Dashtimoghadam,Sahar Ansari,Mohammad Mahdi Hasani-Sadrabadi,Alireza Moshaverinia | | Acta Biomaterialia. 2020; | | [Pubmed] | [DOI] | | | 204 |
Nanotechnology and Immunoengineering: How nanotechnology can boost CAR-T therapy |
|
| Waqas Nawaz,Shijie Xu,Yanlei Li,Bilian Huang,Xilin Wu,Zhiwei Wu | | Acta Biomaterialia. 2020; | | [Pubmed] | [DOI] | | | 205 |
Delivery of LNA-antimiR-142-3p by Mesenchymal Stem Cells-Derived Exosomes to Breast Cancer Stem Cells Reduces Tumorigenicity |
|
| Zahra naseri,Reza Kazemi Oskuee,Mehdi forouzandeh-moghadam,Mahmoud Reza Jaafari | | Stem Cell Reviews and Reports. 2020; | | [Pubmed] | [DOI] | | | 206 |
Polyprenol-Based Lipofecting Agents for In Vivo Delivery of Therapeutic DNA to Treat Hypertensive Rats |
|
| Olga Gawrys,Monika Rak,Iwona Baranowska,Sylwia Bobis-Wozowicz,Karolina Szaro,Zbigniew Madeja,Ewa Swiezewska,Marek Masnyk,Marek Chmielewski,Elzbieta Karnas,Elzbieta Kompanowska-Jezierska | | Biochemical Genetics. 2020; | | [Pubmed] | [DOI] | | | 207 |
Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology |
|
| Angela Rita Armiento,Luan Phelipe Hatt,Guillermo Sanchez Rosenberg,Keith Thompson,Martin James Stoddart | | Advanced Functional Materials. 2020; : 1909874 | | [Pubmed] | [DOI] | | | 208 |
Synthetic Biology and Tissue Engineering: Toward Fabrication of Complex and Smart Cellular Constructs |
|
| Tyler Hoffman,Petar Antovski,Peyton Tebon,Chun Xu,Nureddin Ashammakhi,Samad Ahadian,Leonardo Morsut,Ali Khademhosseini | | Advanced Functional Materials. 2020; : 1909882 | | [Pubmed] | [DOI] | | | 209 |
Multistage Sensitive NanoCRISPR Enable Efficient Intracellular Disruption of Immune Checkpoints for Robust Innate and Adaptive Immune Coactivation |
|
| Ning Wang,Chao Liu,Zhenghao Lu,Wen Yang,Lu Li,Songlin Gong,Tao He,Chunqing Ou,Linjiang Song,Meiling Shen,Qinjie Wu,Changyang Gong | | Advanced Functional Materials. 2020; : 2004940 | | [Pubmed] | [DOI] | | | 210 |
Layer by layer surface engineering of poly(lactide-
co
-glycolide) nanoparticles for plasmid
DNA
delivery |
|
| Angela Michelle T. San Juan,Tina Rodgers,Carlos Bedolla,Francesca Noriega,Gabriela Romero | | Journal of Applied Polymer Science. 2020; : 49377 | | [Pubmed] | [DOI] | | | 211 |
A Synthetic Carrier of Nucleic Acids Structured as a Neutral Phospholipid Envelope Tightly Assembled on Polyplex Surface |
|
| Yonger Xue,Jia Feng,Yilei Liu,Junyi Che,Guang Bai,Xiaotao Dong,Fei Wu,Tuo Jin | | Advanced Healthcare Materials. 2020; : 1901705 | | [Pubmed] | [DOI] | | | 212 |
Is Viral Vector Gene Delivery More Effective Using Biomaterials? |
|
| Yi Wang,Kiara F. Bruggeman,Stephanie Franks,Vini Gautam,Stuart I. Hodgetts,Alan R. Harvey,Richard J. Williams,David R. Nisbet | | Advanced Healthcare Materials. 2020; : 2001238 | | [Pubmed] | [DOI] | | | 213 |
A Cationic Stearamide-based Solid Lipid Nanoparticle for Delivering Yamanaka Factors: Evaluation of the Transfection Efficiency |
|
| Funda Alkan,Hanife Sevgi Varli,Murat Demirbilek,Engin Kaplan,Nelisa Türkoglu Laçin | | ChemistryOpen. 2020; 9(11): 1181 | | [Pubmed] | [DOI] | | | 214 |
The Current Landscape of Novel Formulations and the Role of Mathematical Modeling in Their Development |
|
| Nicolas Cottura,Alice Howarth,Rajith K.R. Rajoli,Marco Siccardi | | The Journal of Clinical Pharmacology. 2020; 60(S1) | | [Pubmed] | [DOI] | | | 215 |
High Molecular Weight Poly(ethylenimine)-Based Water-Soluble Lipopolymer for Transfection of Cancer Cells |
|
| Heba Alaa Hosiny Abd Elhameed,Ditta Ungor,Nóra Igaz,Mohana Krishna Gopisetty,Mónika Kiricsi,Edit Csapó,Béla Gyurcsik | | Macromolecular Bioscience. 2020; : 2000040 | | [Pubmed] | [DOI] | | | 216 |
Physicochemical Properties and Biological Performance of Polymethacrylate Based Gene Delivery Vector Systems: Influence of Amino Functionalities |
|
| Emi Haladjova,Varvara Chrysostomou,Maria Petrova,Iva Ugrinova,Stergios Pispas,Stanislav Rangelov | | Macromolecular Bioscience. 2020; : 2000352 | | [Pubmed] | [DOI] | | | 217 |
Nanoparticulate RNA delivery systems in cancer |
|
| Ankur Sharma,Niraj Kumar Jha,Kajal Dahiya,Vivek Kumar Singh,Kundan Chaurasiya,Aditya Narayan Jha,Saurabh Kumar Jha,Prabhu Chandra Mishra,Sunny Dholpuria,Rani Astya,Parma Nand,Amit Kumar,Janne Ruokolainen,Kavindra Kumar Kesari | | CANCER REPORTS. 2020; | | [Pubmed] | [DOI] | | | 218 |
Optimization of electroporation and other non-viral gene delivery strategies for T cells |
|
| Emily Harris,Jacob J. Elmer | | Biotechnology Progress. 2020; | | [Pubmed] | [DOI] | | | 219 |
Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration |
|
| Karina H. Nakayama,Mahdis Shayan,Ngan F. Huang | | Advanced Healthcare Materials. 2019; : 1801168 | | [Pubmed] | [DOI] | | | 220 |
Effects of human placenta-derived mesenchymal stem cells with NK4 gene expression on glioblastoma multiforme cell lines |
|
| Zahra Jabbarpour,Jafar Kiani,Somayeh Keshtkar,Massoud Saidijam,Mohammad H. Ghahremani,Naser Ahmadbeigi | | Journal of Cellular Biochemistry. 2019; | | [Pubmed] | [DOI] | | | 221 |
High cell density transient transfection of CHO cells for TGF-ß1 expression |
|
| Abdalla A. Elshereef,André Jochums,Antonina Lavrentieva,Lena Stuckenberg,Thomas Scheper,Dörte Solle | | Engineering in Life Sciences. 2019; | | [Pubmed] | [DOI] | | | 222 |
Improved SiRNA Loading of Cationic Nanohydrogel Particles by Variation of Crosslinking Density |
|
| Nadine Leber,Rudolf Zentel | | Macromolecular Chemistry and Physics. 2019; : 1900298 | | [Pubmed] | [DOI] | | | 223 |
Non-viral nucleic acid delivery to the central nervous system and brain tumors |
|
| Shanshan Wang,Rongqin Huang | | The Journal of Gene Medicine. 2019; : e3091 | | [Pubmed] | [DOI] | | | 224 |
The Application of microRNAs in Biomaterial Scaffold-Based Therapies for Bone Tissue Engineering |
|
| Marco A. Arriaga,May-Hui Ding,Astrid S. Gutierrez,Sue Anne Chew | | Biotechnology Journal. 2019; : 1900084 | | [Pubmed] | [DOI] | | | 225 |
Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery |
|
| Yunzhou Fang,Mallika Vadlamudi,Yingbo Huang,Xin Guo | | Pharmaceutical Research. 2019; 36(6) | | [Pubmed] | [DOI] | | | 226 |
Osteogenic Effects of VEGF-Overexpressed Human Adipose-Derived Stem Cells with Whitlockite Reinforced Cryogel for Bone Regeneration |
|
| Inseon Kim,Seunghun S. Lee,Seung Hyun L. Kim,Sunghoon Bae,Hoyon Lee,Nathaniel S. Hwang | | Macromolecular Bioscience. 2019; : 1800460 | | [Pubmed] | [DOI] | | | 227 |
Polymer-mediated gene therapy: Recent advances and merging of delivery techniques |
|
| Janelle W. Salameh,Le Zhou,Sarah M. Ward,Cristiam F. Santa Chalarca,Todd Emrick,Marxa L. Figueiredo | | WIREs Nanomedicine and Nanobiotechnology. 2019; | | [Pubmed] | [DOI] | | | 228 |
Exploring the Functions of polymers in adenovirus-mediated gene delivery: evading immune response and redirecting tropism |
|
| Yanping Sun,Xiaoqian Lv,Pingtian Ding,Long Wang,Yongjun Sun,Shuo Li,Huimin Zhang,Zibin Gao | | Acta Biomaterialia. 2019; | | [Pubmed] | [DOI] | | | 229 |
DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen |
|
| Grace Cole,Ahlam A. Ali,Emma McErlean,Eoghan J. Mulholland,Amy Short,Cian M. McCrudden,Joanne McCaffrey,Tracy Robson,Vicky L. Kett,Jonathan A. Coulter,Nicholas J. Dunne,Ryan F. Donnelly,Helen O. McCarthy | | Acta Biomaterialia. 2019; | | [Pubmed] | [DOI] | | | 230 |
LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats |
|
| Alaa Eldin H. Youssef,Abeer E. Dief,Nesrine M. El Azhary,Doaa A. Abdelmonsif,Ola S. El-fetiany | | Journal of Physiology and Biochemistry. 2019; 75(1): 89 | | [Pubmed] | [DOI] | | | 231 |
Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis |
|
| Jieni Xu,Jingjing Sun,Pui Yan Ho,Zhangyi Luo,Weina Ma,Wenchen Zhao,Sanjay B. Rathod,Christian A. Fernandez,Raman Venkataramanan,Wen Xie,Ai-Ming Yu,Song Li | | Biomaterials. 2019; | | [Pubmed] | [DOI] | | | 232 |
Anti-ageing gene therapy: Not so far away? |
|
| Alexander Vaiserman,Elena De Falco,Alexander Koliada,Olga Maslova,Carmela Rita Balistreri | | Ageing Research Reviews. 2019; 56: 100977 | | [Pubmed] | [DOI] | | | 233 |
Mesenchymal stem cell-associated lncRNA in osteogenic differentiation |
|
| Cheng Ju,Renfeng Liu,Yuan-Wei Zhang,Yu Zhang,Ruihao Zhou,Jun Sun,Xiao-Bin Lv,Zhiping Zhang | | Biomedicine & Pharmacotherapy. 2019; 115: 108912 | | [Pubmed] | [DOI] | | | 234 |
Improved synthesis and characterization of cholesteryl oleate-loaded cationic solid lipid nanoparticles with high transfection efficiency for gene therapy applications |
|
| Marc Suñé-Pou,María J. Limeres,Isaac Nofrerias,Anna Nardi-Ricart,Silvia Prieto-Sánchez,Younes El-Yousfi,Pilar Pérez-Lozano,Encarna García-Montoya,Montserrat Miñarro-Carmona,Josep Ramón Ticó,Cristina Hernández-Munain,Carlos Suñé,Josep Mª Suñé-Negre | | Colloids and Surfaces B: Biointerfaces. 2019; | | [Pubmed] | [DOI] | | | 235 |
Recent Progress of Polymeric Nanogels as Nucleic Acid Delivery Systems |
|
| Rima Kandil,Olivia M. Merkel | | Current Opinion in Colloid & Interface Science. 2019; | | [Pubmed] | [DOI] | | | 236 |
Liposomal delivery of functional transmembrane ion channels into the cell membranes of target cells; A potential approach for the treatment of channelopathies |
|
| Shahenda Ramadan,Salma N. Tammam,Maryam A. Shetab Boushehri,Hans-Georg Breitinger,Ulrike Breitinger,Samar Mansour,Alf Lamprecht | | International Journal of Biological Macromolecules. 2019; | | [Pubmed] | [DOI] | | | 237 |
An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells |
|
| Krishna Kumar Haridhasapavalan,Manash P. Borgohain,Chandrima Dey,Bitan Saha,Gloria Narayan,Sachin Kumar,Rajkumar P. Thummer | | Gene. 2019; 686: 146 | | [Pubmed] | [DOI] | | | 238 |
The study of genes and signal transduction pathways involved in mustard lung injury: A gene therapy approach |
|
| Iman Arabipour,Jafar Amani,Seyed Ali Mirhosseini,Jafar Salimian | | Gene. 2019; : 143968 | | [Pubmed] | [DOI] | | | 239 |
Lipid gene nanocarriers for the treatment of skin diseases: Current state-of-the-art |
|
| Coralie Bellefroid,Anna Lechanteur,Brigitte Evrard,Géraldine Piel | | European Journal of Pharmaceutics and Biopharmaceutics. 2019; 137: 95 | | [Pubmed] | [DOI] | | | 240 |
Modified gelatin nanoparticles for gene delivery |
|
| Osama Madkhali,George Mekhail,Shawn D. Wettig | | International Journal of Pharmaceutics. 2019; 554: 224 | | [Pubmed] | [DOI] | | | 241 |
RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing |
|
| Genghao Chen,Dhruva Katrekar,Prashant Mali | | Biochemistry. 2019; 58(15): 1947 | | [Pubmed] | [DOI] | | | 242 |
[12]aneN3-based single aliphatic chain modified cationic lipids as gene delivery vectors |
|
| Yong-Guang Gao,Fen-Li Liu,Fu-Hua Lu,Uzair Alam,Quan Tang,Jia-Wei Huang,Zhong-Lin Lu | | Tetrahedron. 2019; 75(5): 658 | | [Pubmed] | [DOI] | | | 243 |
Attenuate Newcastle disease virus by codon modification of the glycoproteins and phosphoprotein genes |
|
| Weijia Wang,Xing Cheng,Paul J. Buske,JoAnn A. Suzich,Hong Jin | | Virology. 2019; 528: 144 | | [Pubmed] | [DOI] | | | 244 |
Recombinant AAV-CEA Tumor Vaccine in Combination with an Immune Adjuvant Breaks Tolerance and Provides Protective Immunity |
|
| Jonathan A. Hensel,Vinayak Khattar,Reading Ashton,Selvarangan Ponnazhagan | | Molecular Therapy - Oncolytics. 2019; 12: 41 | | [Pubmed] | [DOI] | | | 245 |
A review of gene- and cell-based therapies for familial hypercholesterolemia |
|
| Saeideh Hajighasemi,Armita Mahdavi Gorabi,Vanessa Bianconi,Matteo Pirro,Maciej Banach,Hossein Ahmadi Tafti,Željko Reiner,Amirhossein Sahebkar | | Pharmacological Research. 2019; 143: 119 | | [Pubmed] | [DOI] | | | 246 |
Synthetic promoter for efficient and muscle-specific expression of exogenous genes |
|
| Yili Liu,Yutong He,Yong Wang,Ming Liu,Mingfeng Jiang,Rong Gao,Gang Wang | | Plasmid. 2019; : 102441 | | [Pubmed] | [DOI] | | | 247 |
Contributions of VPS35 Mutations to Parkinson’s Disease |
|
| Abir A. Rahman,Brad E. Morrison | | Neuroscience. 2019; 401: 1 | | [Pubmed] | [DOI] | | | 248 |
Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats |
|
| Jiang-Hu Huang,Yang Xu,Xiao-Ming Yin,Fei-Yue Lin | | Neuroscience. 2019; | | [Pubmed] | [DOI] | | | 249 |
Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain |
|
| Nicola Salvatore Orefice,Benoît Souchet,Jérôme Braudeau,Sandro Alves,Françoise Piguet,Fanny Collaud,Giuseppe Ronzitti,Satoru Tada,Philippe Hantraye,Federico Mingozzi,Frédéric Ducongé,Nathalie Cartier | | Molecular Therapy - Methods & Clinical Development. 2019; 14: 237 | | [Pubmed] | [DOI] | | | 250 |
Dynamic constitutional chemistry towards efficient nonviral vectors |
|
| Daniela Ailincai,Dragos Peptanariu,Mariana Pinteala,Luminita Marin | | Materials Science and Engineering: C. 2019; 94: 635 | | [Pubmed] | [DOI] | | | 251 |
Shielding of non-target cells using RNA vectors conferring gene transfer resistance: A strategy to enhance targeting accuracy and reduce side-effects in therapeutic gene delivery |
|
| Oleg E. Tolmachov | | Medical Hypotheses. 2019; : 109328 | | [Pubmed] | [DOI] | | | 252 |
Nanostructure Endows Neurotherapeutic Potential in Optogenetics: Current Development and Future Prospects |
|
| Mohammed Nadim Sardoiwala,Anup K. Srivastava,Surajit Karmakar,Subhasree Roy Choudhury | | ACS Chemical Neuroscience. 2019; | | [Pubmed] | [DOI] | | | 253 |
Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery |
|
| Jonas Buck,Philip Grossen,Pieter R. Cullis,Jörg Huwyler,Dominik Witzigmann | | ACS Nano. 2019; 13(4): 3754 | | [Pubmed] | [DOI] | | | 254 |
Three-dimensional microenvironmental priming of human mesenchymal stem cells in hydrogels facilitates efficient and rapid retroviral gene transduction via accelerated cell cycle synchronization |
|
| Yein Lee,Yoshie Arai,Jinsung Ahn,Deogil Kim,Seunghee Oh,Donyoung Kang,Hyungsuk Lee,James J. Moon,Bogyu Choi,Soo-Hong Lee | | NPG Asia Materials. 2019; 11(1) | | [Pubmed] | [DOI] | | | 255 |
Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy |
|
| Khan Muhammad,Jing Zhao,Ihsan Ullah,Jintang Guo,Xiang-kui Ren,Yakai Feng | | Biomaterials Science. 2019; | | [Pubmed] | [DOI] | | | 256 |
Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review |
|
| Sahar Gooneh-Farahani,M. Reza Naimi-Jamal,Seyed Morteza Naghib | | Expert Opinion on Drug Delivery. 2019; 16(1): 79 | | [Pubmed] | [DOI] | | | 257 |
An update on gene therapy for lysosomal storage disorders |
|
| Murtaza S. Nagree,Simone Scalia,William M. McKillop,Jeffrey A. Medin | | Expert Opinion on Biological Therapy. 2019; : 1 | | [Pubmed] | [DOI] | | | 258 |
Optimization and characterization of calcium phosphate transfection in mesenchymal stem cells |
|
| Chi-Wen Lo,Tzu-Hua Lin,Masaya Ueno,Monica Romero-Lopez,Masahiro Maruyama,Yusuke Kohno,Claire Rhee,Zhenyu Yao,Magdiel Pérez-Cruz,Everett Meyer,Stuart B. Goodman | | Tissue Engineering Part C: Methods. 2019; | | [Pubmed] | [DOI] | | | 259 |
Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids |
|
| Tobias Killian,Annette Buntz,Teresa Herlet,Heike Seul,Olaf Mundigl,Gernot Längst,Ulrich Brinkmann | | Nucleic Acids Research. 2019; | | [Pubmed] | [DOI] | | | 260 |
Gene Therapy for Inherited Retinal Degeneration |
|
| Amirmohsen Arbabi,Amelia Liu,Hossein Ameri | | Journal of Ocular Pharmacology and Therapeutics. 2019; | | [Pubmed] | [DOI] | | | 261 |
Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide |
|
| Yoshiyuki Hattori,Yuta Nakagawa,Hiraku Onishi | | Experimental and Therapeutic Medicine. 2019; | | [Pubmed] | [DOI] | | | 262 |
Biomaterial substrate modifications that influence cell-material interactions to prime cellular responses to nonviral gene delivery |
|
| Amy Mantz,Angela K Pannier | | Experimental Biology and Medicine. 2019; 244(2): 100 | | [Pubmed] | [DOI] | | | 263 |
Protein-based vehicles for biomimetic RNAi delivery |
|
| Alex Eli Pottash,Christopher Kuffner,Madeleine Noonan-Shueh,Steven M. Jay | | Journal of Biological Engineering. 2019; 13(1) | | [Pubmed] | [DOI] | | | 264 |
Nucleic acid delivery to mesenchymal stem cells: a review of nonviral methods and applications |
|
| Andrew Hamann,Albert Nguyen,Angela K. Pannier | | Journal of Biological Engineering. 2019; 13(1) | | [Pubmed] | [DOI] | | | 265 |
Neuroglobin Expression Models as a Tool to Study Its Function |
|
| Evi Luyckx,Zoë P. Van Acker,Peter Ponsaerts,Sylvia Dewilde | | Oxidative Medicine and Cellular Longevity. 2019; 2019: 1 | | [Pubmed] | [DOI] | | | 266 |
CRISPR/Cas System for Genome Editing: Progress and Prospects as a Therapeutic Tool |
|
| Deepak Kumar Sahel,Anupama Mittal,Deepak Chitkara | | Journal of Pharmacology and Experimental Therapeutics. 2019; 370(3): 725 | | [Pubmed] | [DOI] | | | 267 |
CANCER DIAGNOSTICS, IMAGING AND TREATMENT BY NANOSCALE STRUCTURES TARGETING |
|
| Öznur Özge ÖZCAN | | Biotechnologia Acta. 2019; 12(6): 12 | | [Pubmed] | [DOI] | | | 268 |
Recent advances in the development of gene delivery systems |
|
| YK Sung,SW Kim | | Biomaterials Research. 2019; 23(1) | | [Pubmed] | [DOI] | | | 269 |
The Delivery of Personalised, Precision Medicines via Synthetic Proteins |
|
| Benedita Kaç Labbé Feron,Simon Clifford Wainwright Richardson | | Drug Delivery Letters. 2019; 9(2): 79 | | [Pubmed] | [DOI] | | | 270 |
Advances in Targeted Gene Delivery |
|
| Anjuman A. Begum,Istvan Toth,Waleed M. Hussein,Peter M. Moyle | | Current Drug Delivery. 2019; 16(7): 588 | | [Pubmed] | [DOI] | | | 271 |
Designer Nucleases: Gene-Editing Therapies using CCR5 as an Emerging Target in HIV |
|
| Maria João Almeida,Ana Matos | | Current HIV Research. 2019; 17(5): 306 | | [Pubmed] | [DOI] | | | 272 |
Long Noncoding RNAs in Acute Myeloid Leukemia: Functional Characterization and Clinical Relevance |
|
| Morgane Gourvest,Pierre Brousset,Marina Bousquet | | Cancers. 2019; 11(11): 1638 | | [Pubmed] | [DOI] | | | 273 |
Cancer Treatment Goes Viral: Using Viral Proteins to Induce Tumour-Specific Cell Death |
|
| Jasmine Wyatt,Manuel M. Müller,Mahvash Tavassoli | | Cancers. 2019; 11(12): 1975 | | [Pubmed] | [DOI] | | | 274 |
Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases |
|
| JinWoo Hong,Chae-Ok Yun | | Cells. 2019; 8(5): 392 | | [Pubmed] | [DOI] | | | 275 |
miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally? |
|
| A K M Nawshad Hossian,Gerardo G Mackenzie,George Mattheolabakis | | Nanomedicine. 2019; | | [Pubmed] | [DOI] | | | 276 |
Lipidoid iron oxide nanoparticles are a platform for nucleic acid delivery to the liver |
|
| V.I. Uvarova,T.R. Nizamov,M.A. Abakumov,S.S. Vodopyanov,T.O. Abakumova,I.V. Saltykova,P.S. Mogilnikov,I.V. Shchetinin,A.M. Majouga | | Bulletin of Russian State Medical University. 2019; (6): 40 | | [Pubmed] | [DOI] | | | 277 |
?????????????? ??????????? ?????? ?????? ??? ????????? ??? ???????? ??????????? ?????? ? ?????? |
|
| ?. ?. ???????,?. ?. ???????,?. ?. ????????,?. ?. ??????????,?. ?. ?????????,?. ?. ?????????,?. ?. ???????????,?. ?. ???????,?. ?. ?????? | | ??????? ??????????? ???????????????? ???????????? ????????????. 2019; (6): 43 | | [Pubmed] | [DOI] | | | 278 |
Novel Delivery Systems for Checkpoint Inhibitors |
|
| Purushottam Lamichhane,Rahul Deshmukh,Julie A. Brown,Silvia Jakubski,Priyanka Parajuli,Todd Nolan,Dewan Raja,Mary Badawy,Thomas Yoon,Mark Zmiyiwsky,Narottam Lamichhane | | Medicines. 2019; 6(3): 74 | | [Pubmed] | [DOI] | | | 279 |
Electrospinning Nanofibers for Therapeutics Delivery |
|
| S. Shahriar,Jagannath Mondal,Mohammad Hasan,Vishnu Revuri,Dong Lee,Yong-Kyu Lee | | Nanomaterials. 2019; 9(4): 532 | | [Pubmed] | [DOI] | | | 280 |
Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics |
|
| Maurilio Sokullu,Maurilio Soleymani Abyaneh,Maurilio Gauthier | | Pharmaceutics. 2019; 11(5): 211 | | [Pubmed] | [DOI] | | | 281 |
Chitosan in Non-Viral Gene Delivery: Role of Structure, Characterization Methods, and Insights in Cancer and Rare Diseases Therapies |
|
| Beatriz Santos-Carballal,Elena Fernández Fernández,Francisco Goycoolea | | Polymers. 2018; 10(4): 444 | | [Pubmed] | [DOI] | | | 282 |
Intravenous Delivery of piggyBac Transposons as a Useful Tool for Liver-Specific Gene-Switching |
|
| Shingo Nakamura,Masayuki Ishihara,Satoshi Watanabe,Naoko Ando,Masato Ohtsuka,Masahiro Sato | | International Journal of Molecular Sciences. 2018; 19(11): 3452 | | [Pubmed] | [DOI] | | | 283 |
Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets |
|
| Diana Rafael,Fernanda Andrade,Sara Montero,Petra Gener,Joaquin Seras-Franzoso,Francesc Martínez,Patricia González,Helena Florindo,Diego Arango,Joan Sayós,Ibane Abasolo,Mafalda Videira,Simó Schwartz Jr. | | Precision Nanomedicine. 2018; 1(2): 86 | | [Pubmed] | [DOI] | | | 284 |
Recombinant Histones as an Instrument for the Delivery of Nucleic Acids into Eukaryotic Cells |
|
| M. V. Zinovyeva,A. V. Sass,A. V. Vvedensky,V. K. Potapov,L. G. Nikolaev,E. D. Sverdlov | | Molecular Genetics, Microbiology and Virology. 2018; 33(3): 187 | | [Pubmed] | [DOI] | | | 285 |
Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics |
|
| Graham McClorey,Subhashis Banerjee | | Biomedicines. 2018; 6(2): 51 | | [Pubmed] | [DOI] | | | 286 |
Combined use of plasmid drug pCMV-VEGFA and autodermoplasty for stimulation of skin defects healing in the experiment |
|
| A. I Bilialov, M. S Abyzova, A. A Titova, M. O Mavlikeev, AA. Krilov, I. Y Bozo, R. V Deev | | Genes & Cells. 2018; 13(1): 90 | | [Pubmed] | [DOI] | | | 287 |
Directed myogenic reprogramming of differentiated cells |
|
| F. A Indeikin, M. O Mavlikeev, R. V Deev | | Genes & Cells. 2018; 13(4): 9 | | [Pubmed] | [DOI] | | | 288 |
Desarrollo de vectores génicos basados en polímeros sintéticos: PEI y PDMAEMA |
|
| Ivonne Lorena Díaz-Ariza,César Augusto Sierra,León Darío Pérez-Pérez | | Revista Colombiana de Ciencias Químico-Farmacéuticas. 2018; 47(3): 350 | | [Pubmed] | [DOI] | | | 289 |
Recombinant histones as an instrument for delivery of nucleic acids into eukaryotic cells |
|
| M. V. Zinovyeva,A. V. Sass,A. V. Vvedensky,V. K. Potapov,L. G. Nikolaev,E. D. Sverdlov | | Molecular Genetics Microbiology and Virology (Russian version). 2018; 36(3): 30 | | [Pubmed] | [DOI] | | | 290 |
Recent advances in stem cell therapeutics and tissue engineering strategies |
|
| Seong Gyu Kwon,Yang Woo Kwon,Tae Wook Lee,Gyu Tae Park,Jae Ho Kim | | Biomaterials Research. 2018; 22(1) | | [Pubmed] | [DOI] | | | 291 |
Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells |
|
| Thomas Del’Guidice,Jean-Pascal Lepetit-Stoffaes,Louis-Jean Bordeleau,Joannie Roberge,Vanessa Théberge,Coraline Lauvaux,Xavier Barbeau,Jessica Trottier,Vibhuti Dave,Denis-Claude Roy,Bruno Gaillet,Alain Garnier,David Guay,Alfred S Lewin | | PLOS ONE. 2018; 13(4): e0195558 | | [Pubmed] | [DOI] | | | 292 |
Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing |
|
| Yu Zhang,Chengzu Long,Rhonda Bassel-Duby,Eric N. Olson | | Physiological Reviews. 2018; 98(3): 1205 | | [Pubmed] | [DOI] | | | 293 |
Efficient Nonviral Transfection of Human Bone Marrow Mesenchymal Stromal Cells Shown Using Placental Growth Factor Overexpression |
|
| Winston Y. Cheung,Owen Hovey,Jonathan M. Gobin,Gauri Muradia,Jelica Mehic,Carole Westwood,Jessie R. Lavoie | | Stem Cells International. 2018; 2018: 1 | | [Pubmed] | [DOI] | | | 294 |
Cell surface engineering and application in cell delivery to heart diseases |
|
| Daniel Y. Lee,Byung-Hyun Cha,Minjin Jung,Angela S. Kim,David A. Bull,Young-Wook Won | | Journal of Biological Engineering. 2018; 12(1) | | [Pubmed] | [DOI] | | | 295 |
Therapeutic effects of a mesenchymal stem cell-based insulin-like growth factor-1/enhanced green fluorescent protein dual gene sorting system in a myocardial infarction rat model |
|
| Subin Jung,Jung-Hyun Kim,Changwhi Yim,Minhyung Lee,Hyo Kang,Donghoon Choi | | Molecular Medicine Reports. 2018; | | [Pubmed] | [DOI] | | | 296 |
Evaluating Nonintegrating Lentiviruses as Safe Vectors for Noninvasive Reporter-Based Molecular Imaging of Multipotent Mesenchymal Stem Cells |
|
| Amanda M. Hamilton,Paula J. Foster,John A. Ronald | | Human Gene Therapy. 2018; 29(10): 1213 | | [Pubmed] | [DOI] | | | 297 |
Poly-l-lysine-coated superparamagnetic nanoparticles: a novel method for the transfection of pro-BDNF into neural stem cells |
|
| Salim Naama Albukhaty,Hossein Naderi-Manesh,Tiraihi Taqi,Majid Sakhi Jabir | | Artificial Cells, Nanomedicine, and Biotechnology. 2018; : 1 | | [Pubmed] | [DOI] | | | 298 |
Enhanced gene transfection efficiency by low-dose 25?kDa polyethylenimine by the assistance of 1.8?kDa polyethylenimine |
|
| Hui Zhang,Zhiyi Chen,Meng Du,Yue Li,Yuhao Chen | | Drug Delivery. 2018; 25(1): 1740 | | [Pubmed] | [DOI] | | | 299 |
Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon |
|
| Abbas Zakeri,Mohammad Amin Jadidi Kouhbanani,Nasrin Beheshtkhoo,Vahid Beigi,Seyyed Mojtaba Mousavi,Seyyed Ali Reza Hashemi,Ayoob Karimi Zade,Ali Mohammad Amani,Amir Savardashtaki,Esmail Mirzaei,Sara Jahandideh,Ahmad Movahedpour | | Nano Reviews & Experiments. 2018; 9(1): 1488497 | | [Pubmed] | [DOI] | | | 300 |
Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site |
|
| Tatiana Kotomina,Daniil Korenkov,Victoria Matyushenko,Polina Prokopenko,Larisa Rudenko,Irina Isakova-Sivak | | Human Vaccines & Immunotherapeutics. 2018; | | [Pubmed] | [DOI] | | | 301 |
Enhanced transfection of a macromolecular lignin-based DNA complex with low cellular toxicity |
|
| Yoon Khei Ho,Dan Kai,Geraldine Xue En Tu,G. Roshan Deen,Heng Phon Too,Xian Jun Loh | | Bioscience Reports. 2018; 38(6) | | [Pubmed] | [DOI] | | | 302 |
Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles |
|
| Marianna Yanez Arteta,Tomas Kjellman,Stefano Bartesaghi,Simonetta Wallin,Xiaoqiu Wu,Alexander J. Kvist,Aleksandra Dabkowska,Noémi Székely,Aurel Radulescu,Johan Bergenholtz,Lennart Lindfors | | Proceedings of the National Academy of Sciences. 2018; : 201720542 | | [Pubmed] | [DOI] | | | 303 |
The method of chicken whole embryo culture using the eggshell windowing, surrogate eggshell and ex ovo culture system |
|
| M. Farzaneh,F. Attari,S. E. Khoshnam,P. E. Mozdziak | | British Poultry Science. 2018; : 1 | | [Pubmed] | [DOI] | | | 304 |
Current viral-mediated gene transfer research for treatment of Alzheimer’s disease |
|
| Andrew Octavian Sasmita | | Biotechnology and Genetic Engineering Reviews. 2018; : 1 | | [Pubmed] | [DOI] | | | 305 |
Hepatocellular targeted a-tocopherol based pH sensitive galactosylated lipids: design, synthesis and transfection studies |
|
| Venkanna Muripiti,Brijesh Lohchania,Srujan Kumar Marepally,Srilakshmi V. Patri | | MedChemComm. 2018; | | [Pubmed] | [DOI] | | | 306 |
Transfection efficiencies of a-tocopherylated cationic gemini lipids with hydroxyethyl bearing headgroups under high serum conditions |
|
| Bappa Maiti,Mohini Kamra,Anjali A. Karande,Santanu Bhattacharya | | Organic & Biomolecular Chemistry. 2018; | | [Pubmed] | [DOI] | | | 307 |
A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy |
|
| Wenjun Li,Dongyuan Wang,Xiaodong Shi,Jingxu Li,Yue Ma,Yanding Wang,Tingting Li,Jianing Zhang,Rongtong Zhao,Zhiqiang Yu,Feng Yin,Zigang Li | | Materials Horizons. 2018; | | [Pubmed] | [DOI] | | | 308 |
PEGylated Chitosan for Nonviral Aerosol and Mucosal Delivery of the CRISPR/Cas9 System in Vitro |
|
| Hairui Zhang,Tania F. Bahamondez-Canas,Yajie Zhang,Jasmim Leal,Hugh D.C. Smyth | | Molecular Pharmaceutics. 2018; | | [Pubmed] | [DOI] | | | 309 |
A Universal GSH-Responsive Nanoplatform for the Delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein |
|
| Guojun Chen,Ben Ma,Yuyuan Wang,Shaoqin Gong | | ACS Applied Materials & Interfaces. 2018; | | [Pubmed] | [DOI] | | | 310 |
Engineering Human Epidermal Growth Receptor 2-Targeting Hepatitis B Virus Core Nanoparticles for siRNA Delivery in Vitro and in Vivo |
|
| Izzat F. M. Suffian,Julie T.-W. Wang,Farid N. Faruqu,Julio Benitez,Yuya Nishimura,Chiaki Ogino,Akihiko Kondo,Khuloud T. Al-Jamal | | ACS Applied Nano Materials. 2018; | | [Pubmed] | [DOI] | | | 311 |
BMP2 expressing genetically engineered mesenchymal stem cells on composite fibrous scaffolds for enhanced bone regeneration in segmental defects |
|
| Shruthy Kuttappan,A. Anitha,M.G. Minsha,Parvathy M. Menon,T.B. Sivanarayanan,Lakshmi Sumitra Vijayachandran,Manitha B. Nair | | Materials Science and Engineering: C. 2018; | | [Pubmed] | [DOI] | | | 312 |
RNA Structure Design Improves Activity and Specificity of trans -Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach |
|
| Sushmita Poddar,Pei She Loh,Zi Hao Ooi,Farhana Osman,Joachim Eul,Volker Patzel | | Molecular Therapy - Nucleic Acids. 2018; 11: 41 | | [Pubmed] | [DOI] | | | 313 |
The determination of gemini surfactants used as gene delivery agents in cellular matrix using validated tandem mass spectrometric method |
|
| Jin Wei,Badea Ildiko,C. Leary Scot,El-need Anas | | Journal of Pharmaceutical and Biomedical Analysis. 2018; | | [Pubmed] | [DOI] | | | 314 |
Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates |
|
| Hadeer M. Abdelaziz,Mohamed Gaber,Mahmoud M. Abd-Elwakil,Moustafa T. Mabrouk,Mayada M. Elgohary,Nayra M. Kamel,Dalia M. Kabary,May S. Freag,Magda W. Samaha,Sana M. Mortada,Kadria A. Elkhodairy,Jia-You Fang,Ahmed O. Elzoghby | | Journal of Controlled Release. 2018; 269: 374 | | [Pubmed] | [DOI] | | | 315 |
Exosomes: natural nanoparticles as bio shuttles for RNAi delivery |
|
| Saber Ghazizadeh Darband,Mohammad Mirza-Aghazadeh-Attari,Mojtaba Kaviani,Ainaz Mihanfar,Shirin Sadighparvar,Bahman Yousefi,Maryam Majidinia | | Journal of Controlled Release. 2018; 289: 158 | | [Pubmed] | [DOI] | | | 316 |
In vivo methods for acute modulation of gene expression in the central nervous system |
|
| Andrzej W. Cwetsch,Bruno Pinto,Annalisa Savardi,Laura Cancedda | | Progress in Neurobiology. 2018; | | [Pubmed] | [DOI] | | | 317 |
Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in Nicotiana benthamiana |
|
| Peyman Habibi,Carlos Ricardo Soccol,Barry R. O’Keefe,Lauren R.H. Krumpe,Jennifer Wilson,Leonardo Lima Pepino de Macedo,Muhammad Faheem,Vanessa Olinto Dos Santos,Guilherme Souza Prado,Marco Antonio Botelho,Severine Lacombe,Maria Fatima Grossi-de-Sa | | Process Biochemistry. 2018; | | [Pubmed] | [DOI] | | | 318 |
Beyond gene transfection with methacrylate-based polyplexes – the influence of the amino substitution pattern |
|
| Ulrich S. Schubert,Tanja Bus,Martin Reifarth,Johannes C. Brendel,Stephanie Hoeppener,Anja Traeger,Anne-Kristin Trützschler | | Bioconjugate Chemistry. 2018; | | [Pubmed] | [DOI] | | | 319 |
Electrostatically assembled dendrimer complex with a high-affinity protein binder for targeted gene delivery |
|
| Jong-won Kim,Joong-jae Lee,Joon Sig Choi,Hak-Sung Kim | | International Journal of Pharmaceutics. 2018; 544(1): 39 | | [Pubmed] | [DOI] | | | 320 |
Design of PEI-conjugated bio-reducible polymer for efficient gene delivery |
|
| Joung-Pyo Nam,Soyoung Kim,Sung Wan Kim | | International Journal of Pharmaceutics. 2018; | | [Pubmed] | [DOI] | | | 321 |
Structure-activity relationship of serotonin derived tocopherol lipids |
|
| Venkanna Muripiti,Thasneem Yoosuf Mujahid,Venkata Harsha Vardhan Boddeda,Shrish Tiwari,Srujan Kumar Marepally,Srilakshmi V Patri,Vijaya Gopal | | International Journal of Pharmaceutics. 2018; | | [Pubmed] | [DOI] | | | 322 |
Nucleic-acid based gene therapy approaches for sepsis |
|
| Yuichi Hattori,Kohshi Hattori,Tokiko Suzuki,Sailesh Palikhe,Naoyuki Matsuda | | European Journal of Pharmacology. 2018; | | [Pubmed] | [DOI] | | | 323 |
Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery |
|
| Anjuman Ara Begum,Yu Wan,Istvan Toth,Peter M. Moyle | | Bioorganic & Medicinal Chemistry. 2018; 26(2): 516 | | [Pubmed] | [DOI] | | | 324 |
Preparation of gene drug delivery systems of Cationic peptide lipid with 0G-PAMAM as hydrophilic end and its biological properties evaluation |
|
| Yingying Feng,Hu Haimei,Shuanghong liang,Dan Wang | | Chemistry and Physics of Lipids. 2018; | | [Pubmed] | [DOI] | | | 325 |
Acylation of the S413-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions |
|
| Catarina M. Morais,Ana M. Cardoso,Pedro P. Cunha,Luísa Aguiar,Nuno Vale,Emílio Lage,Marina Pinheiro,Cláudia Nunes,Paula Gomes,Salette Reis,M. Margarida C.A. Castro,Maria C. Pedroso de Lima,Amália S. Jurado | | Biochimica et Biophysica Acta (BBA) - Biomembranes. 2018; 1860(12): 2619 | | [Pubmed] | [DOI] | | | 326 |
Gene therapy and type 1 diabetes mellitus |
|
| Dinesh Kumar Chellappan,Nandhini S. Sivam,Kai Xiang Teoh,Wai Pan Leong,Tai Zhen Fui,Kien Chooi,Nico Khoo,Fam Jia Yi,Jestin Chellian,Lim Lay Cheng,Rajiv Dahiya,Gaurav Gupta,Gautam Singhvi,Srinivas Nammi,Philip Michael Hansbro,Kamal Dua | | Biomedicine & Pharmacotherapy. 2018; 108: 1188 | | [Pubmed] | [DOI] | | | 327 |
Crustacean nuclear localization signals help facilitating the delivery of DNA into Australian red-claw crayfish cells |
|
| Chan D.H. Nguyen,Tomer Ventura,Abigail Elizur | | Aquaculture. 2018; | | [Pubmed] | [DOI] | | | 328 |
Engineering DNA vaccines against infectious diseases |
|
| Jihui Lee,Shreedevi Arun Kumar,Yong Yu Jhan,Corey J. Bishop | | Acta Biomaterialia. 2018; | | [Pubmed] | [DOI] | | | 329 |
Therapeutic potential of combined viral transduction and CRISPR/Cas9 gene editing in treating neurodegenerative diseases |
|
| Joshua Kuruvilla,Andrew Octavian Sasmita,Anna Pick Kiong Ling | | Neurological Sciences. 2018; | | [Pubmed] | [DOI] | | | 330 |
Comparison of random and gradient amino functionalized poly(2-oxazoline)s: Can the transfection efficiency be tuned by the macromolecular structure? |
|
| David Hertz,Meike N. Leiske,Thomas Wloka,Anja Traeger,Matthias Hartlieb,Michael M. Kessels,Stephanie Schubert,Britta Qualmann,Ulrich S. Schubert | | Journal of Polymer Science Part A: Polymer Chemistry. 2018; | | [Pubmed] | [DOI] | | | 331 |
Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer |
|
| Mauro Almeida,Mariana Magalhães,Francisco Veiga,Ana Figueiras | | Journal of Polymer Research. 2018; 25(1) | | [Pubmed] | [DOI] | | | 332 |
Engineering and cytosolic delivery of a native regulatory protein and its variants for modulation of ERK2 signaling pathway |
|
| Jeong-Hyun Ryou,Yoo-Kyoung Sohn,Dong-Gun Kim,Hyun-Ho Kyeong,Hak-Sung Kim | | Biotechnology and Bioengineering. 2018; | | [Pubmed] | [DOI] | | | 333 |
Mechanisms of unprimed and dexamethasone-primed nonviral gene delivery to human mesenchymal stem cells |
|
| Andrew Hamann,Kelly Broad,Albert Nguyen,Angela K. Pannier | | Biotechnology and Bioengineering. 2018; | | [Pubmed] | [DOI] | | | 334 |
Multimeric Amphipathic a-Helical Sequences for Rapid and Efficient Intracellular Protein Transport at Nanomolar Concentrations |
|
| Jae Hoon Oh,Seung-Eun Chong,Sohee Nam,Soonsil Hyun,Sejong Choi,Hyojun Gye,Sangmok Jang,Joomyung Jang,Sung Won Hwang,Jaehoon Yu,Yan Lee | | Advanced Science. 2018; : 1800240 | | [Pubmed] | [DOI] | | | 335 |
Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases |
|
| Bikash R. Giri,Ram I. Mahato,Guofeng Cheng | | Medicinal Research Reviews. 2018; | | [Pubmed] | [DOI] | | | 336 |
Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
|
| Raul A. Bastarrachea,Jiaxi Chen,Jack W. Kent,Edna J. Nava-Gonzalez,Ernesto Rodriguez-Ayala,Marcel M. Daadi,Barbara Jorge,Hugo Laviada-Molina,Anthony G. Comuzzie,Shuyuan Chen,Paul A. Grayburn | | IUBMB Life. 2017; | | [Pubmed] | [DOI] | | | 337 |
Mesenchymal stem cells: A new platform for targeting suicide genes in cancer |
|
| Rana Moradian Tehrani,Javad Verdi,Mahdi Noureddini,Rasoul Salehi,Reza Salarinia,Meysam Mosalaei,Miganosh Simonian,Behrang Alani,Moosa Rahimi Ghiasi,Mahmoud Reza Jaafari,Hamed Reza Mirzaei,Hamed Mirzaei | | Journal of Cellular Physiology. 2017; | | [Pubmed] | [DOI] | | | 338 |
Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives |
|
| Jelena Rnjak-Kovacina,Fengying Tang,John M. Whitelock,Megan S. Lord | | Advanced Healthcare Materials. 2017; : 1701042 | | [Pubmed] | [DOI] | | | 339 |
Plant viral and bacteriophage delivery of nucleic acid therapeutics |
|
| Patricia Lam,Nicole F. Steinmetz | | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2017; : e1487 | | [Pubmed] | [DOI] | | | 340 |
Retro-inverso d -peptide-modified hyaluronic acid/bioreducible hyperbranched poly(amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids |
|
| Jijin Gu,Xinyi Chen,Xiaoling Fang,Xianyi Sha | | Acta Biomaterialia. 2017; | | [Pubmed] | [DOI] | | | 341 |
Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells: Development of polyethyleneimineoligonucleotide hybridization probes |
|
| Seungmin Han,Hye Young Son,Byunghoon Kang,Eunji Jang,Jisun Ki,Na Geum Lee,Jongjin Park,Moo-Kwang Shin,Byeonggeol Mun,Jeong-Ki Min,Seungjoo Haam | | Nano Research. 2017; | | [Pubmed] | [DOI] | | | 342 |
Exosome-based small RNA delivery: progress and prospects |
|
| Mei Lu,Haonan Xing,Zhe Xun,Tianzhi Yang,Pingtian Ding,Cuifang Cai,Dongkai Wang,Xiaoyun Zhao | | Asian Journal of Pharmaceutical Sciences. 2017; | | [Pubmed] | [DOI] | | | 343 |
Modulating angiogenesis with integrin-targeted nanomedicines |
|
| Aroa Duro-Castano,Elena Gallon,Caitlin Decker,María J. Vicent | | Advanced Drug Delivery Reviews. 2017; | | [Pubmed] | [DOI] | | | 344 |
Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing |
|
| Zoi Piperigkou,Martin Götte,Achilleas D. Theocharis,Nikos K. Karamanos | | Advanced Drug Delivery Reviews. 2017; | | [Pubmed] | [DOI] | | | 345 |
Functional therapies for cutaneous wound repair in epidermolysis bullosa |
|
| Patricia Peking,Ulrich Koller,Eva M. Murauer | | Advanced Drug Delivery Reviews. 2017; | | [Pubmed] | [DOI] | | | 346 |
Targeting renal fibrosis: Mechanisms and drug delivery systems |
|
| Madalina V. Nastase,Jinyang Zeng-Brouwers,Malgorzata Wygrecka,Liliana Schaefer | | Advanced Drug Delivery Reviews. 2017; | | [Pubmed] | [DOI] | | | 347 |
Sustained viral gene delivery from a micro-fibrous, elastomeric cardiac patch to the ischemic rat heart |
|
| Xinzhu Gu,Yasumoto Matsumura,Ying Tang,Souvik Roy,Richard Hoff,Bing Wang,William R. Wagner | | Biomaterials. 2017; 133: 132 | | [Pubmed] | [DOI] | | | 348 |
Boron nitride nanotubes for gene silencing |
|
| Özlem Sen,Zehra Çobandede,Melis Emanet,Ömer Faruk Bayrak,Mustafa Çulha | | Biochimica et Biophysica Acta (BBA) - General Subjects. 2017; | | [Pubmed] | [DOI] | | | 349 |
Functionalized 2D nanomaterials for gene delivery applications |
|
| Feng Yin,Bobo Gu,Yining Lin,Nishtha Panwar,Swee Chuan Tjin,Junle Qu,Shu Ping Lau,Ken-Tye Yong | | Coordination Chemistry Reviews. 2017; 347: 77 | | [Pubmed] | [DOI] | | | 350 |
Integrated microfluidic devices for the synthesis of nanoscale liposomes and lipoplexes |
|
| Tiago A. Balbino,Juliana M. Serafin,Allan Radaic,Marcelo B. de Jesus,Lucimara G. de la Torre | | Colloids and Surfaces B: Biointerfaces. 2017; | | [Pubmed] | [DOI] | | | 351 |
Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown |
|
| Shashank Reddy Pinnapireddy,Lili Duse,Boris Strehlow,Jens Schäfer,Udo Bakowsky | | Colloids and Surfaces B: Biointerfaces. 2017; | | [Pubmed] | [DOI] | | | 352 |
Recent advances on extracellular vesicles in therapeutic delivery: challenges, solutions, and opportunities |
|
| Mei Lu,Haonan Xing,Zhen Yang,Yanping Sun,Tianzhi Yang,Xiaoyun Zhao,Cuifang Cai,Dongkai Wang,Pingtian Ding | | European Journal of Pharmaceutics and Biopharmaceutics. 2017; | | [Pubmed] | [DOI] | | | 353 |
Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine |
|
| Cody S. Lee,Elliot S. Bishop,Ruyi Zhang,Xinyi Yu,Evan M. Farina,Shujuan Yan,Chen Zhao,Zongyue Zeng,Yi Shu,Xingye Wu,Jiayan Lei,Yasha Li,Wenwen Zhang,Chao Yang,Ke Wu,Ying Wu,Sherwin Ho,Aravind Athiviraham,Michael J. Lee,Jennifer Moriatis Wolf,Russell R. Reid,Tong-Chuan He | | Genes & Diseases. 2017; 4(2): 43 | | [Pubmed] | [DOI] | | | 354 |
Improved formulation of cationic solid lipid nanoparticles displays cellular uptake and biological activity of nucleic acids |
|
| Anna Fàbregas,Silvia Prieto-Sánchez,Marc Suñé-Pou,Sofía Boyero-Corral,Josep Ramón Ticó,Encarna García-Montoya,Pilar Pérez-Lozano,Montserrat Miñarro,Josep Mª Suñé-Negre,Cristina Hernández-Munain,Carlos Suñé | | International Journal of Pharmaceutics. 2017; 516(1-2): 39 | | [Pubmed] | [DOI] | | | 355 |
Surfactant effect on the physicochemical characteristics of cationic solid lipid nanoparticles |
|
| Chiara Botto,Nicolò Mauro,Erika Amore,Elisabetta Martorana,Gaetano Giammona,Maria Luisa Bondì | | International Journal of Pharmaceutics. 2017; 516(1-2): 334 | | [Pubmed] | [DOI] | | | 356 |
Modifying plasmid-loaded HSA-nanoparticles with cell penetrating peptides – Cellular uptake and enhanced gene delivery |
|
| J. Mesken,A. Iltzsche,D. Mulac,K. Langer | | International Journal of Pharmaceutics. 2017; 522(1-2): 198 | | [Pubmed] | [DOI] | | | 357 |
Synthesis and Degradation Study of Cationic Polycaprolactone-Based Nanoparticles for Biomedical and Industrial Applications |
|
| Azzurra Agostini,Simone Gatti,Alberto Cesana,Davide Moscatelli | | Industrial & Engineering Chemistry Research. 2017; 56(20): 5872 | | [Pubmed] | [DOI] | | | 358 |
Polyplex Evolution: Understanding Biology, Optimizing Performance |
|
| Arnaldur Hall,Ulrich Lächelt,Jiri Bartek,Ernst Wagner,Seyed Moein Moghimi | | Molecular Therapy. 2017; | | [Pubmed] | [DOI] | | | 359 |
Pharmacological Reprogramming of Somatic Cells for Regenerative Medicine |
|
| Min Xie,Shibing Tang,Ke Li,Sheng Ding | | Accounts of Chemical Research. 2017; | | [Pubmed] | [DOI] | | | 360 |
Generation and Characterization of Virus-Enhancing Peptide Nanofibrils Functionalized with Fluorescent Labels |
|
| Sascha Rode,Manuel Hayn,Annika Röcker,Stefanie Sieste,Markus Lamla,Daniel Markx,Christoph Meier,Frank Kirchhoff,Paul Walther,Marcus Fändrich,Tanja Weil,Jan Münch | | Bioconjugate Chemistry. 2017; 28(4): 1260 | | [Pubmed] | [DOI] | | | 361 |
Evolution of New “Bolaliposomes” using Novel a-Tocopheryl Succinate Based Cationic Lipid and 1,12-Disubstituted Dodecane-Based Bolaamphiphile for Efficient Gene Delivery |
|
| Mallikarjun Gosangi,Hithavani Rapaka,Venkatesh Ravula,Srilakshmi V. Patri | | Bioconjugate Chemistry. 2017; | | [Pubmed] | [DOI] | | | 362 |
The evolution of heart failure with reduced ejection fraction pharmacotherapy: What do we have and where are we going? |
|
| Ahmed Selim,Ronald Zolty,Yiannis S. Chatzizisis | | Pharmacology & Therapeutics. 2017; | | [Pubmed] | [DOI] | | | 363 |
Interactions between microRNAs and long non-coding RNAs in cardiac development and repair |
|
| Alessio Rotini,Ester Martínez-Sarrà,Enrico Pozzo,Maurilio Sampaolesi | | Pharmacological Research. 2017; | | [Pubmed] | [DOI] | | | 364 |
Hydrodynamic gene delivery in human skin using a hollow microneedle device |
|
| M Dul,M Stefanidou,P Porta,J Serve,C OæMahony,B Malissen,S Henri,Y Levin,E Kochba,FS Wong,C Dayan,SA Coulman,JC Birchall | | Journal of Controlled Release. 2017; | | [Pubmed] | [DOI] | | | 365 |
Polymeric nanoparticles as cancer-specific DNA delivery vectors to human hepatocellular carcinoma |
|
| Camila G. Zamboni,Kristen L. Kozielski,Hannah J. Vaughan,Maisa M. Nakata,Jayoung Kim,Luke J. Higgins,Martin G. Pomper,Jordan J. Green | | Journal of Controlled Release. 2017; | | [Pubmed] | [DOI] | | | 366 |
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases |
|
| Christos Tapeinos,Matteo Battaglini,Gianni Ciofani | | Journal of Controlled Release. 2017; | | [Pubmed] | [DOI] | | | 367 |
Genetically modified mesenchymal stem/stromal cells transfected with adiponectin gene can stably secrete adiponectin |
|
| Md. Murad Hossain,Malliga Raman Murali,Tunku Kamarul | | Life Sciences. 2017; 182: 50 | | [Pubmed] | [DOI] | | | 368 |
Acceleration of bone regeneration in bioactive glass/gelatin composite scaffolds seeded with bone marrow-derived mesenchymal stem cells over-expressing bone morphogenetic protein-7 |
|
| Saeid Kargozar,Seyed Jafar Hashemian,Mansooreh Soleimani,Peiman Brouki Milan,Mohammad Askari,Vahid Khalaj,Ali Samadikuchaksaraie,Sepideh Hamzehlou,Amir Reza Katebi,Noorahmad Latifi,Masoud Mozafari,Francesco Baino | | Materials Science and Engineering: C. 2017; 75: 688 | | [Pubmed] | [DOI] | | | 369 |
Freezing-Assisted Gene Delivery Combined with Polyampholyte Nanocarriers |
|
| Sana Ahmed,Tadashi Nakaji-Hirabayashi,Takayoshi Watanabe,Takahiro Hohsaka,Kazuaki Matsumura | | ACS Biomaterials Science & Engineering. 2017; | | [Pubmed] | [DOI] | | | 370 |
Green Transfection: Cationic Lipid Nanocarrier System Derivatized from Vegetable Fat, Palmstearin Enhances Nucleic Acid Transfections |
|
| Priya Dharmalingam,Hari Krishna R. Rachamalla,Brijesh Lohchania,Bhanuprasad Bandlamudi,Saravanabhavan Thangavel,Mohankumar K. Murugesan,Rajkumar Banerjee,Arabinda Chaudhuri,Chandrashekhar Voshavar,Srujan Marepally | | ACS Omega. 2017; 2(11): 7892 | | [Pubmed] | [DOI] | | | 371 |
Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells |
|
| Haixia Gong,Menglin Liu,Jeff Klomp,Bradley J. Merrill,Jalees Rehman,Asrar B. Malik | | Scientific Reports. 2017; 7: 42127 | | [Pubmed] | [DOI] | | | 372 |
Basic concepts and recent advances in nanogels as carriers for medical applications |
|
| Iordana Neamtu,Alina Gabriela Rusu,Alina Diaconu,Loredana Elena Nita,Aurica P. Chiriac | | Drug Delivery. 2017; 24(1): 539 | | [Pubmed] | [DOI] | | | 373 |
Ternary complex of plasmid DNA with NLS-Mu-Mu protein and cationic niosome for biocompatible and efficient gene delivery: a comparative study with protamine and lipofectamine |
|
| Mohammad Hadi Nematollahi,Masoud Torkzadeh-Mahanai,Abbas Pardakhty,Hossein Ali Ebrahimi Meimand,Gholamreza Asadikaram | | Artificial Cells, Nanomedicine, and Biotechnology. 2017; : 1 | | [Pubmed] | [DOI] | | | 374 |
Gene therapies development: slow progress and promising prospect |
|
| Eve Hanna,Cécile Rémuzat,Pascal Auquier,Mondher Toumi | | Journal of Market Access & Health Policy. 2017; 5(1): 1265293 | | [Pubmed] | [DOI] | | | 375 |
Synthesis of magnetic cytosine-imprinted chitosan nanoparticles |
|
| Mei-Hwa Lee,Arti Ahluwalia,Jian-Zhou Chen,Neng-Lang Shih,Hung-Yin Lin | | Nanotechnology. 2017; 28(8): 085705 | | [Pubmed] | [DOI] | | | 376 |
Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering |
|
| Francesca Busuttil,Ahad A. Rahim,James B. Phillips | | Stem Cells and Development. 2017; | | [Pubmed] | [DOI] | | | 377 |
Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients with Intestinal Failure |
|
| Sung Noh Hong,James C.Y. Dunn,Matthias Stelzner,Martín G. Martín | | STEM CELLS Translational Medicine. 2017; 6(2): 666 | | [Pubmed] | [DOI] | | | 378 |
Bioengineered liposome–scaffold composites as therapeutic delivery systems |
|
| Claudia Zylberberg,Sandro Matosevic | | Therapeutic Delivery. 2017; 8(6): 425 | | [Pubmed] | [DOI] | | | 379 |
Stimuli-Regulated Smart Polymeric Systems for Gene Therapy |
|
| Ansuja Mathew,Ki-Hyun Cho,Saji Uthaman,Chong-Su Cho,In-Kyu Park | | Polymers. 2017; 9(4): 152 | | [Pubmed] | [DOI] | | | 380 |
Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery |
|
| Seulgi Lee,Sang Son,Su Song,Tai Ha,Joon Choi | | Polymers. 2017; 9(6): 224 | | [Pubmed] | [DOI] | | | 381 |
A mechanistic investigation exploring the differential transfection efficiencies between the easy-to-transfect SK-BR3 and difficult-to-transfect CT26 cell lines |
|
| Elizabeth Figueroa,Pallavi Bugga,Vishwaratn Asthana,Allen L. Chen,J. Stephen Yan,Emily Reiser Evans,Rebekah A. Drezek | | Journal of Nanobiotechnology. 2017; 15(1) | | [Pubmed] | [DOI] | | | 382 |
Block copolymer conjugated Au-coated Fe3O4 nanoparticles as vectors for enhancing colloidal stability and cellular uptake |
|
| Junbo Li,Sheng Zou,Jiayu Gao,Ju Liang,Huiyun Zhou,Lijuan Liang,Wenlan Wu | | Journal of Nanobiotechnology. 2017; 15(1) | | [Pubmed] | [DOI] | | | 383 |
Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs |
|
| Eun-Kyoung Bang,Hanna Cho,Sean S.-H. Jeon,Na Ly Tran,Dong-Kwon Lim,Wooyoung Hur,Taebo Sim | | Chemical Biology & Drug Design. 2017; | | [Pubmed] | [DOI] | | | 384 |
Transfection Studies with Colloidal Systems Containing Highly Purified Bipolar Tetraether Lipids from Sulfolobus acidocaldarius |
|
| Konrad H. Engelhardt,Shashank Reddy Pinnapireddy,Elias Baghdan,Jarmila Jedelská,Udo Bakowsky | | Archaea. 2017; 2017: 1 | | [Pubmed] | [DOI] | | | 385 |
Honing Cell and Tissue Culture Conditions for Bone and Cartilage Tissue Engineering |
|
| Johnny Lam,Esther J. Lee,Elisa C. Clark,Antonios G. Mikos | | Cold Spring Harbor Perspectives in Medicine. 2017; 7(12): a025734 | | [Pubmed] | [DOI] | | | 386 |
Molecular Communication and Nanonetwork for Targeted Drug Delivery: A Survey |
|
| Uche A. K. Chude-Okonkwo,Reza Malekian,B. T. Maharaj,Athanasios V. Vasilakos | | IEEE Communications Surveys & Tutorials. 2017; 19(4): 3046 | | [Pubmed] | [DOI] | | | 387 |
Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes |
|
| Marie Rouanet,Marine Lebrin,Fabian Gross,Barbara Bournet,Pierre Cordelier,Louis Buscail | | International Journal of Molecular Sciences. 2017; 18(6): 1231 | | [Pubmed] | [DOI] | | | 388 |
Technical Improvement and Application of Hydrodynamic Gene Delivery in Study of Liver Diseases |
|
| Mei Huang,Rui Sun,Qiang Huang,Zhigang Tian | | Frontiers in Pharmacology. 2017; 8 | | [Pubmed] | [DOI] | | | 389 |
Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer |
|
| Faroogh Marofi,Ghasem Vahedi,Alireza Biglari,Abdolreza Esmaeilzadeh,Seyyed Shamsadin Athari | | Frontiers in Immunology. 2017; 8 | | [Pubmed] | [DOI] | | | 390 |
Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System |
|
| Diego Pignataro,Diego Sucunza,Lucia Vanrell,Esperanza Lopez-Franco,Iria G. Dopeso-Reyes,Africa Vales,Mirja Hommel,Alberto J. Rico,Jose L. Lanciego,Gloria Gonzalez-Aseguinolaza | | Frontiers in Neuroanatomy. 2017; 11 | | [Pubmed] | [DOI] | | | 391 |
Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases |
|
| Ibrahim M El-Sherbiny,Nancy M Elbaz,Mohammed Sedki,Abdulaziz Elgammal,Magdi H Yacoub | | Nanomedicine. 2017; | | [Pubmed] | [DOI] | | | 392 |
The use of nanoparticulates to treat breast cancer |
|
| Xiaomeng Tang,Welley S Loc,Cheng Dong,Gail L Matters,Peter J Butler,Mark Kester,Craig Meyers,Yixing Jiang,James H Adair | | Nanomedicine. 2017; | | [Pubmed] | [DOI] | | | 393 |
Multifaceted Applications of Chitosan in Cancer Drug Delivery and Therapy |
|
| Anish Babu,Rajagopal Ramesh | | Marine Drugs. 2017; 15(4): 96 | | [Pubmed] | [DOI] | | | 394 |
An Electrostatically Self-Assembled Ternary Nanocomplex as a Non-Viral Vector for the Delivery of Plasmid DNA into Human Adipose-Derived Stem Cells |
|
| Sun-Hee Cho,Young-Woock Noh,Mi Cho,Yong Lim | | Molecules. 2016; 21(5): 572 | | [Pubmed] | [DOI] | | | 395 |
MicroRNAs Regulate Cytokine Responses in Gingival Epithelial Cells |
|
| Steven C. Y. Chen,Christos Constantinides,Moritz Kebschull,Panos N. Papapanou,B. A. McCormick | | Infection and Immunity. 2016; 84(12): 3282 | | [Pubmed] | [DOI] | | | 396 |
Therapeutic nucleic acids: current clinical status |
|
| Kannan Sridharan,Nithya Jaideep Gogtay | | British Journal of Clinical Pharmacology. 2016; 82(3): 659 | | [Pubmed] | [DOI] | | | 397 |
Systematically probing the bottom-up synthesis of AuPAMAM conjugates for enhanced transfection efficiency |
|
| Elizabeth R. Figueroa,J. Stephen Yan,Nicolette K. Chamberlain-Simon,Adam Y. Lin,Aaron E. Foster,Rebekah A. Drezek | | Journal of Nanobiotechnology. 2016; 14(1) | | [Pubmed] | [DOI] | | | 398 |
Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases |
|
| Dipti Deshpande,David R. Janero,Victor Segura-Ibarra,Elvin Blanco,Mansoor M. Amiji | | Methodist DeBakey Cardiovascular Journal. 2016; 12(3): 134 | | [Pubmed] | [DOI] | | | 399 |
A COMPARISON OF UNILAMELLAR AND MULTILAMELLAR LIPOPLEXES IN TERMS OF TRANSFECTION EFFICIENCY OF HUMAN EMBRYONIC KIDNEY CELLS |
|
| Mohmood Tavallaie | | Journal of Nanotechnology and Materials Science. 2016; 3(2): 1 | | [Pubmed] | [DOI] | | | 400 |
New polymer of lactic-co-glycolic acid-modified polyethylenimine for nucleic acid delivery |
|
| Jian-Ming Lü,Zhengdong Liang,Xiaoxiao Wang,Jianhua Gu,Qizhi Yao,Changyi Chen | | Nanomedicine. 2016; 11(15): 1971 | | [Pubmed] | [DOI] | | | 401 |
Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles |
|
| Igor M Pongrac,Marina Dobrivojevic,Lada Brkic Ahmed,Michal Babic,Miroslav Šlouf,Daniel Horák,Srecko Gajovic | | Beilstein Journal of Nanotechnology. 2016; 7: 926 | | [Pubmed] | [DOI] | | | 402 |
Significance of stem cell marker Nanog gene in the diagnosis and prognosis of lung cancer |
|
| Zeng Liu,Jing Zhang,Honggang Kang,Guiming Sun,Baozhong Wang,Yanwen Wang,Mengxiang Yang | | Oncology Letters. 2016; 12(4): 2507 | | [Pubmed] | [DOI] | | | 403 |
Genetic Modification of the Lung Directed Toward Treatment of Human Disease |
|
| Dolan Sondhi,Katie Stiles,Bishnu P De,Ronald G Crystal | | Human Gene Therapy. 2016; | | [Pubmed] | [DOI] | | | 404 |
Integrated Electrowetting Nanoinjector for Single Cell Transfection |
|
| Elaheh Shekaramiz,Ganeshkumar Varadarajalu,Philip J. Day,H. Kumar Wickramasinghe | | Scientific Reports. 2016; 6: 29051 | | [Pubmed] | [DOI] | | | 405 |
Functional lipids based on [12]aneN3and naphthalimide as efficient non-viral gene vectors |
|
| Yong-Guang Gao,Uzair Alam,Quan Tang,You-Di Shi,Ying Zhang,Ruibing Wang,Zhong-Lin Lu | | Org. Biomol. Chem.. 2016; 14(26): 6346 | | [Pubmed] | [DOI] | | | 406 |
A novel non-viral gene vector for hepatocyte-targeting and in situ monitoring of DNA delivery in single cells |
|
| Yong-Guang Gao,Quan Tang,You-Di Shi,Ying Zhang,Ruibing Wang,Zhong-Lin Lu | | RSC Adv.. 2016; 6(55): 50053 | | [Pubmed] | [DOI] | | | 407 |
Nanomaterial mediated optogenetics: opportunities and challenges |
|
| Kai Huang,Qingqing Dou,Xian Jun Loh | | RSC Adv.. 2016; 6(65): 60896 | | [Pubmed] | [DOI] | | | 408 |
Vascular Repair by Circumferential Cell Therapy Using Magnetic Nanoparticles and Tailored Magnets |
|
| Sarah Vosen,Sarah Rieck,Alexandra Heidsieck,Olga Mykhaylyk,Katrin Zimmermann,Wilhelm Bloch,Dietmar Eberbeck,Christian Plank,Bernhard Gleich,Alexander Pfeifer,Bernd K. Fleischmann,Daniela Wenzel | | ACS Nano. 2016; 10(1): 369 | | [Pubmed] | [DOI] | | | 409 |
Effect of sustained PDGF nonviral gene delivery on repair of tooth-supporting bone defects |
|
| A B Plonka,B Khorsand,N Yu,J V Sugai,A K Salem,W V Giannobile,S Elangovan | | Gene Therapy. 2016; | | [Pubmed] | [DOI] | | | 410 |
Mapping of bionic array electric field focusing in plasmid DNA-based gene electrotransfer |
|
| C J Browne,J L Pinyon,D M Housley,E N Crawford,N H Lovell,M Klugmann,G D Housley | | Gene Therapy. 2016; | | [Pubmed] | [DOI] | | | 411 |
ORMOPLEXEs for gene therapy: In vitro and in vivo assays |
|
| J.C. Matos,A.R. Soares,I. Domingues,G.A. Monteiro,M.C. Gonçalves | | Materials Science and Engineering: C. 2016; 63: 546 | | [Pubmed] | [DOI] | | | 412 |
Therapeutic and diagnostic applications of extracellular vesicles |
|
| Stephan Stremersch,Stefaan C. De Smedt,Koen Raemdonck | | Journal of Controlled Release. 2016; | | [Pubmed] | [DOI] | | | 413 |
Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium |
|
| Sarah Vosen,Sarah Rieck,Alexandra Heidsieck,Olga Mykhaylyk,Katrin Zimmermann,Christian Plank,Bernhard Gleich,Alexander Pfeifer,Bernd K. Fleischmann,Daniela Wenzel | | Journal of Controlled Release. 2016; | | [Pubmed] | [DOI] | | | 414 |
Epigenome Editing: State of the Art, Concepts, and Perspectives |
|
| Goran Kungulovski,Albert Jeltsch | | Trends in Genetics. 2016; 32(2): 101 | | [Pubmed] | [DOI] | | | 415 |
Coordinative Amphiphiles as Tunable siRNA Transporters |
|
| Jin Bum Kim,Yeong Mi Lee,Jooyeon Ryu,Eunji Lee,Won Jong Kim,Gyochang Keum,Eun-Kyoung Bang | | Bioconjugate Chemistry. 2016; | | [Pubmed] | [DOI] | | | 416 |
Gene delivery using calcium phosphate nanoparticles: Optimization of the transfection process and the effects of citrate and poly(l-lysine) as additives |
|
| Mohammed A. Khan,Victoria M. Wu,Shreya Ghosh,Vuk Uskokovic | | Journal of Colloid and Interface Science. 2016; 471: 48 | | [Pubmed] | [DOI] | | | 417 |
Gene transfer to the outflow tract |
|
| Yalong Dang,Ralitsa Loewen,Hardik A. Parikh,Pritha Roy,Nils A. Loewen | | Experimental Eye Research. 2016; | | [Pubmed] | [DOI] | | | 418 |
Gene based therapies for kidney regeneration |
|
| Manoe J. Janssen,Fanny O. Arcolino,Perry Schoor,Robbert Jan Kok,Enrico Mastrobattista | | European Journal of Pharmacology. 2016; | | [Pubmed] | [DOI] | | | 419 |
Micro and nanotechnologies in heart valve tissue engineering |
|
| Anwarul Hasan,John Saliba,Hassan Pezeshgi Modarres,Ahmed Bakhaty,Amir Nasajpour,Mohammad R.K. Mofrad,Amir Sanati-Nezhad | | Biomaterials. 2016; 103: 278 | | [Pubmed] | [DOI] | | | 420 |
Cationic ß-Cyclodextrin–Chitosan Conjugates as Potential Carrier for pmCherry-C1 Gene Delivery |
|
| Touba Eslaminejad,Seyed Noureddin Nematollahi-Mahani,Mehdi Ansari | | Molecular Biotechnology. 2016; 58(4): 287 | | [Pubmed] | [DOI] | | | 421 |
Conjugates of small targeting molecules to non-viral vectors for the mediation of siRNA |
|
| Defu Zhi,Yinan Zhao,Shaohui Cui,Huiying Chen,Shubiao Zhang | | Acta Biomaterialia. 2016; 36: 21 | | [Pubmed] | [DOI] | | | 422 |
Graphene-based materials for tissue engineering |
|
| Su Ryon Shin,Yi-Chen Li,HaeLin Jang,Parastoo Khoshakhlagh,Mohsen Akbari,Amir Nasajpour,Yu Shrike Zhang,Ali Tamayol,Ali Khademhosseini | | Advanced Drug Delivery Reviews. 2016; | | [Pubmed] | [DOI] | | | 423 |
Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry |
|
| Rong Ni,Junli Zhou,Naushad Hossain,Ying Chau | | Advanced Drug Delivery Reviews. 2016; | | [Pubmed] | [DOI] | | | 424 |
The promising alliance of anti-cancer electrochemotherapy with immunotherapy |
|
| Christophe Y. Calvet,Lluis M. Mir | | Cancer and Metastasis Reviews. 2016; | | [Pubmed] | [DOI] | | | 425 |
High-throughput screening of clinically approved drugs that prime polyethylenimine transfection reveals modulation of mitochondria dysfunction response improves gene transfer efficiencies |
|
| Albert Nguyen,Jared Beyersdorf,Jean-Jack Riethoven,Angela K. Pannier | | Bioengineering & Translational Medicine. 2016; | | [Pubmed] | [DOI] | | | 426 |
Neprilysin gene transfer: A promising therapeutic approach for Alzheimeræs disease |
|
| Yuanli Li,Junqing Wang,Shenghao Zhang,Zhaohui Liu | | Journal of Neuroscience Research. 2015; 93(9): 1325 | | [Pubmed] | [DOI] | | | 427 |
Generation of stable cell line by using chitosan as gene delivery system |
|
| Emine Salva,Suna Özbas Turan,Ceyda Ekentok,Jülide Akbuga | | Cytotechnology. 2015; | | [Pubmed] | [DOI] | | | 428 |
Using Stem Cells to Model Diseases of the Outer Retina |
|
| Camille Yvon,Conor M. Ramsden,Amelia Lane,Michael B. Powner,Lyndon da Cruz,Peter J. Coffey,Amanda-Jayne F. Carr | | Computational and Structural Biotechnology Journal. 2015; 13: 382 | | [Pubmed] | [DOI] | | | 429 |
Anticancer effect of gene/peptide co-delivery system using transferrin-grafted LMWSC |
|
| Gyeong-Won Jeong,Seong-Cheol Park,Changyong Choi,Joung-Pyo Nam,Tae-Hun Kim,Soo-Kyung Choi,Jun-Kyu Park,Jae-Woon Nah | | International Journal of Pharmaceutics. 2015; 488(1-2): 165 | | [Pubmed] | [DOI] | | | 430 |
Polyamidoamine (PAMAM) dendrimers modified with short oligopeptides for early endosomal escape and enhanced gene delivery |
|
| Le Thi Thuy,Sudipta Mallick,Joon Sig Choi | | International Journal of Pharmaceutics. 2015; 492(1-2): 233 | | [Pubmed] | [DOI] | | | 431 |
Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy |
|
| Simeon K. Adesina,Emmanuel O. Akala | | Molecular Pharmaceutics. 2015; | | [Pubmed] | [DOI] | | | 432 |
Delivery of drugs and macromolecules to the mitochondria for cancer therapy |
|
| Phong Lu,Benjamin J. Bruno,Malena Rabenau,Carol S. Lim | | Journal of Controlled Release. 2015; | | [Pubmed] | [DOI] | | | 433 |
Poly(ethylenimine) conjugated bioreducible dendrimer for efficient gene delivery |
|
| Kihoon Nam,Simhyun Jung,Joung-Pyo Nam,Sung Wan Kim | | Journal of Controlled Release. 2015; 220: 447 | | [Pubmed] | [DOI] | | | 434 |
Nanotechnology for mesenchymal stem cell therapies |
|
| Bruna Corradetti,Mauro Ferrari | | Journal of Controlled Release. 2015; | | [Pubmed] | [DOI] | | | 435 |
Stimuli-responsive liposomes for the delivery of nucleic acid therapeutics |
|
| Fatemeh Movahedi,Rebecca G. Hu,David L. Becker,Chenjie Xu | | Nanomedicine: Nanotechnology, Biology and Medicine. 2015; 11(6): 1575 | | [Pubmed] | [DOI] | | | 436 |
A naphthalimide-based [12]aneN3compound as an effective and real-time fluorescence tracking non-viral gene vector |
|
| Yong-Guang Gao,You-Di Shi,Ying Zhang,Jing Hu,Zhong-Lin Lu,Lan He | | Chem. Commun.. 2015; 51(93): 16695 | | [Pubmed] | [DOI] | | | 437 |
Highly luminescent and cytocompatible cationic Ag2S NIR-emitting quantum dots for optical imaging and gene transfection |
|
| Fatma Demir Duman,Ibrahim Hocaoglu,Deniz Gulfem Ozturk,Devrim Gozuacik,Alper Kiraz,Havva Yagci Acar | | Nanoscale. 2015; 7(26): 11352 | | [Pubmed] | [DOI] | | | 438 |
Enhancement of nucleic acid delivery to hard-to-transfect human colorectal cancer cells by magnetofection at laminin coated substrates and promotion of the endosomal/lysosomal escape |
|
| María Belén Cerda,Milena Batalla,Martina Anton,Eduardo Cafferata,Osvaldo Podhajcer,Christian Plank,Olga Mykhaylyk,Lucia Policastro | | RSC Adv.. 2015; 5(72): 58345 | | [Pubmed] | [DOI] | | | 439 |
Synthesis of bifunctional molecules containing [12]aneN3and coumarin moieties as effective DNA condensation agents and new non-viral gene vectors |
|
| Pan Yue,Ying Zhang,Zhi-Fo Guo,Ao-Cheng Cao,Zhong-Lin Lu,Yong-Gong Zhai | | Org. Biomol. Chem.. 2015; 13(15): 4494 | | [Pubmed] | [DOI] | | | 440 |
Gene therapy for ocular diseases meditated by ultrasound and microbubbles (Review) |
|
| Caifeng Wan,Fenghua Li,Hongli Li | | Molecular Medicine Reports. 2015; | | [Pubmed] | [DOI] | | | 441 |
Iron Oxide Nanoparticles Coated with a Phosphorothioate Oligonucleotide and a Cationic Peptide: Exploring Four Different Ways of Surface Functionalization |
|
| Frédéric Geinguenaud,Claire Banissi,Antoine Carpentier,Laurence Motte | | Nanomaterials. 2015; 5(4): 1588 | | [Pubmed] | [DOI] | | | 442 |
Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems |
|
| Babak Bakhshinejad,Majid Sadeghizadeh | | Expert Opinion on Drug Delivery. 2014; : 1 | | [Pubmed] | [DOI] | | | 443 |
Gene Therapy for Inherited Muscle Diseases |
|
| Robynne Braun,Zejing Wang,David L. Mack,Martin K. Childers | | American Journal of Physical Medicine & Rehabilitation. 2014; 93: S97 | | [Pubmed] | [DOI] | | | 444 |
Gene therapy in pancreatic cancer |
|
| Si-Xue Liu | | World Journal of Gastroenterology. 2014; 20(37): 13343 | | [Pubmed] | [DOI] | | | 445 |
Human umbilical cord blood derived mesenchymal stem cells were differentiated into pancreatic endocrine cell by Pdx-1 electrotransfer |
|
| Phuoc Thi-My Nguyen,Anh Thai-Quynh Nguyen,Nhung Thi Nguyen,Nguyet Thi-Minh Nguyen,Thu Thi Duong,Nhung Hai Truong,Ngoc Kim Phan | | Biomedical Research and Therapy. 2014; 1(2) | | [Pubmed] | [DOI] | | | 446 |
A dual gold nanoparticle system for mesenchymal stem cell tracking |
|
| L. M. Ricles,S. Y. Nam,E. A. Treviño,S. Y. Emelianov,L. J. Suggs | | J. Mater. Chem. B. 2014; 2(46): 8220 | | [Pubmed] | [DOI] | | | 447 |
Advances in Lipid-Based Platforms for RNAi Therapeutics |
|
| Sara Falsini,Laura Ciani,Sandra Ristori,Angelo Fortunato,Annarosa Arcangeli | | Journal of Medicinal Chemistry. 2014; 57(4): 1138 | | [Pubmed] | [DOI] | | | 448 |
Injection parameters and virus dependent choice of promoters to improve neuron targeting in the nonhuman primate brain |
|
| W Lerchner,B Corgiat,V Der Minassian,R C Saunders,B J Richmond | | Gene Therapy. 2014; | | [Pubmed] | [DOI] | | | 449 |
Effective Gene Delivery into Human Stem Cells with a Cell-Targeting Peptide-Modified Bioreducible Polymer |
|
| Jagadish Beloor,Suresh Ramakrishna,Kihoon Nam,Chang Seon Choi,Jongkil Kim,Sung Hwa Kim,Hyong Jin Cho,HeungSoo Shin,Hyongbum Kim,Sung Wan Kim,Sang-Kyung Lee,Priti Kumar | | Small. 2014; : n/a | | [Pubmed] | [DOI] | | | 450 |
Ultrasound-mediated transgene expression in endogenous stem cells recruited to bone injury sites |
|
| Galina Shapiro,Ilan Kallai,Dmitriy Sheyn,Wafa Tawackoli,Young Do Koh,Hyun Bae,Tamar Trietel,Riki Goldbart,Joseph Kost,Zulma Gazit,Dan Gazit,Gadi Pelled | | Polymers for Advanced Technologies. 2014; : n/a | | [Pubmed] | [DOI] | | | 451 |
Polymeric Nanoparticle System to Target activated microglia/macrophages in Spinal Cord Injury |
|
| Simonetta Papa,Raffaele Ferrari,Massimiliano De Paola,Filippo Rossi,Alessandro Mariani,Ilaria Caron,Eliana Sammali,Marco Peviani,Valentina Dell’Oro,Claudio Colombo,Massimo Morbidelli,Gianluigi Forloni,Giuseppe Perale,Davide Moscatelli,Pietro Veglianese | | Journal of Controlled Release. 2013; | | [Pubmed] | [DOI] | | | 452 |
Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles |
|
| Zhi-Yi Chen,Yan Lin,Feng Yang,Lan Jiang,Shu ping Ge | | Cardiovascular Ultrasound. 2013; 11(1): 11 | | [Pubmed] | [DOI] | |
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