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  Indian J Med Microbiol
 

Figure 8: Characterized mechanisms of histone deacetylasesHDACs in pancreatic ductal adenocarcinomaPDAC. Three histone deacetylasesHDAC pathways are demonstrated. Right part: histone deacetylasesHDACs control expression of the CDKI p21Cip1/Waf1 and cyclin B1 to control the G1/S-phase or G2/M-phase or the cell cycle. Middle part: histone deacetylasesHDACs contribute to the imbalanced expression of the anti-apoptotic (BCLw, MCL1, BCLXL, and c-Flip) and pro-apoptotic (BIM, BAX, and NOXA) genes. Left part: histone deacetylases HDAC1 and 2 containing repressor complex is recruited to the E-box of the E-cadherin promoter by the transcription factor SNAIL

Figure 8: Characterized mechanisms of histone deacetylasesHDACs in pancreatic ductal adenocarcinomaPDAC. Three histone deacetylasesHDAC pathways are demonstrated. Right part: histone deacetylasesHDACs control expression of the CDKI p21Cip1/Waf1 and cyclin B1 to control the G1/S-phase or G2/M-phase or the cell cycle. Middle part: histone deacetylasesHDACs contribute to the imbalanced expression of the anti-apoptotic (BCLw, MCL1, BCLXL, and c-Flip) and pro-apoptotic (BIM, BAX, and NOXA) genes. Left part: histone deacetylases HDAC1 and 2 containing repressor complex is recruited to the E-box of the E-cadherin promoter by the transcription factor SNAIL