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  Indian J Med Microbiol
 

Figure 2: Effect of fluvoxamine on cyclooxygenase-2 expression in lipopolysaccharide-induced U937 macrophages. (a) The cells pretreated with the indicated concentrations of fluvoxamine (10−6 M: d), (10−7 M: c), and (10−8 M: b) for 1 h, and then, the cells were activated with lipopolysaccharide (1 μ g/ml) (a: untreated cells). After 24 h, expression of cyclooxygenase-2 was measured by flow cytometry. (b) Fluvoxamine considerably decreases the expression of cyclooxygenase-2 in 10−6 M and 10−7 M concentration. Mean ± standard deviation values of experiments are shown. *P < 0.05, ***P < 0.001 compared with control group

Figure 2: Effect of fluvoxamine on cyclooxygenase-2 expression in lipopolysaccharide-induced U937 macrophages. (a) The cells pretreated with the indicated concentrations of fluvoxamine (10−<sup>6</sup> M: d), (10−<sup>7</sup> M: c), and (10−<sup>8</sup> M: b) for 1 h, and then, the cells were activated with lipopolysaccharide (1 <b>μ</b> g/ml) (a: untreated cells). After 24 h, expression of cyclooxygenase-2 was measured by flow cytometry. (b) Fluvoxamine considerably decreases the expression of cyclooxygenase-2 in 10−<sup>6</sup> M and 10−<sup>7</sup> M concentration. Mean ± standard deviation values of experiments are shown. *<i>P</i> < 0.05, ***<i>P</i> < 0.001 compared with control group