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  Indian J Med Microbiol
 

Figure 1: Histopathological evaluation of duodenum following whole body irradiation and treatment with melatonin or its combination with metformin. Treatment with melatonin and metformin did not cause any remarkable change in the histology of duodenum. (a): control; (b): melatonin treatment; (c): metformin treatment. Whole body irradiation led to shortening of villi (d, ×100) and also congestion, degeneration, and reduction of goblet cells (e, ×400). Irradiation plus melatonin treatment alleviate villi damage (f, ×100) and other degenerative changes (g, ×400). Irradiation plus melatonin and metformin treatment also reversed shortening of villi (h, ×100), damage to goblet cells and degenerative changes (i, ×400) (H and E staining)

Figure 1: Histopathological evaluation of duodenum following whole body irradiation and treatment with melatonin or its combination with metformin. Treatment with melatonin and metformin did not cause any remarkable change in the histology of duodenum. (a): control; (b): melatonin treatment; (c): metformin treatment. Whole body irradiation led to shortening of villi (d, ×100) and also congestion, degeneration, and reduction of goblet cells (e, ×400). Irradiation plus melatonin treatment alleviate villi damage (f, ×100) and other degenerative changes (g, ×400). Irradiation plus melatonin and metformin treatment also reversed shortening of villi (h, ×100), damage to goblet cells and degenerative changes (i, ×400) (H and E staining)