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  Indian J Med Microbiol
 

Figure 2: Alterations of expression/level (ELISA) of cAMP response element-binding protein (total form) (a), phosphorylated forms of cAMP response element-binding protein, (b) and brain-derived neurotrophic factor (c) in hippocampus in negative control group and group under treatment with 10 mg/kg of methamphetamine (positive control) and groups under treatment by methamphetamine in combination with bupropion (20 mg/kg), forced exercise, or under bupropion in combination with forced exercise. All data are expressed as mean ± standard error of the mean (n = 8). METH: Methamphetamine, P-CREB: Phosphorylated forms of cAMP response element-binding protein. ***Significant level with P < 0.001 in comparison to negative control group, ###Significant level with P < 0.001 in comparison to methamphetamine-treated group (received 10 mg/kg of methamphetamine)

Figure 2: Alterations of expression/level (ELISA) of cAMP response element-binding protein (total form) (a), phosphorylated forms of cAMP response element-binding protein, (b) and brain-derived neurotrophic factor (c) in hippocampus in negative control group and group under treatment with 10 mg/kg of methamphetamine (positive control) and groups under treatment by methamphetamine in combination with bupropion (20 mg/kg), forced exercise, or under bupropion in combination with forced exercise. All data are expressed as mean ± standard error of the mean (<i>n</i> = 8). METH: Methamphetamine, P-CREB: Phosphorylated forms of cAMP response element-binding protein. ***Significant level with <i>P</i> < 0.001 in comparison to negative control group, <sup>###</sup>Significant level with <i>P</i> < 0.001 in comparison to methamphetamine-treated group (received 10 mg/kg of methamphetamine)