Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 1  |  Page : 9-

Evaluation the effects of Eucalyptus essential oil and hypertonic saline as scolicidal agents in induction of sclerosing cholangitis in rabbits


Seyed Vahid Hosseini1, Maytham Hameed Al-Qanbar2, Hajar Khazraei1, Shahin Khodaei1, Maral Mokhtari3, Pooya Iranpour4 
1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Kufa Univerisity of Medical Sciences, Kufa, Iraq
3 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Dr. Hajar Khazraei
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz
Iran

Background: There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis (SC) and liver necrosis. The present study aimed to evaluate the adverse effects of Eucalyptus essential oil to induce SC in animal models. Materials and Methods: Eighteen rabbits weighting 2000–3500 g were included in three groups for this study. About 0.3 ml of Eucalyptus essential oil (1%), or 5% hypertonic saline, or normal saline was injected for 5 min in the gallbladder. After 4 months, the liver, common bile duct, and duodenum were resected and immediately sent for cholangiography and pathologic studies. Results: According to pathological studies, inflammation is more common in Eucalyptus and hypertonic saline groups. Due to cholangiographic studies, stricture was slightly higher in the hypertonic saline group than the Eucalyptus group. Conclusion: Thus, 1% Eucalyptus essential oil is at least as safe as 5% hypertonic saline, but for clinical uses, it must be confirmed with further studies.


How to cite this article:
Hosseini SV, Al-Qanbar MH, Khazraei H, Khodaei S, Mokhtari M, Iranpour P. Evaluation the effects of Eucalyptus essential oil and hypertonic saline as scolicidal agents in induction of sclerosing cholangitis in rabbits.Adv Biomed Res 2020;9:9-9


How to cite this URL:
Hosseini SV, Al-Qanbar MH, Khazraei H, Khodaei S, Mokhtari M, Iranpour P. Evaluation the effects of Eucalyptus essential oil and hypertonic saline as scolicidal agents in induction of sclerosing cholangitis in rabbits. Adv Biomed Res [serial online] 2020 [cited 2020 May 30 ];9:9-9
Available from: http://www.advbiores.net/article.asp?issn=2277-9175;year=2020;volume=9;issue=1;spage=9;epage=9;aulast=Hosseini;type=0