Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 1  |  Page : 64-

Interaction of Sex Hormones and the Renin–Angiotensin System in Ovariectomized Rats Subjected to Ischemia-Reperfusion Induction


Halimeh Lakzaei, Tahereh Safari, Gholam Reza Komeili 
 Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Correspondence Address:
Dr. Tahereh Safari
Department of Physiology, School of Medicine, Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan
Iran

Backgrounds: Ischemia-reperfusion (IR) injuries occur in a variety of clinical conditions, which lead to kidney damage. Most of the tissue damages after IR are due to the activation of the renin–angiotensin system (RAS). Hence, in this study, the interaction of sex hormones and RAS in ovariectomized (OV) rats subjected to IR induction has been studied. Materials and Methods: The animals were divided into different groups. Groups 1 (OV + E, OV rat + estradiol) and 2 (OV rat) each one consisted of three separate IR-induced subgroups treated with losartan, angiotensin 1–7 (Ang 1–7), and their combination, Group 3, as control and Group 4, as sham. Next, 72 h after IR, blood samples were collected, the right kidneys were homogenized, and left kidneys were fixed in 10% formalin. Results: Findings show that serum blood urea nitrogen, creatinine, and kidney tissue damage score levels increased significantly with induction of IR (P < 0.05). Mean serum levels of these factors in OV + E groups are higher than those of the OV. The presence or absence of estradiol did not affect the levels of antioxidants in the different groups receiving Los, Ang 1–7, and their combination. Los, Ang 1–7, and their combination reduced serum and kidney malondialdehyde levels in both OV and OV + E groups. Conclusion: Estrogen not only fails to improve renal functioning but it can also exacerbate it. While the treatments used in this study, in the absence of estradiol, it had a better effect on kidney damages and improved its functions.


How to cite this article:
Lakzaei H, Safari T, Komeili GR. Interaction of Sex Hormones and the Renin–Angiotensin System in Ovariectomized Rats Subjected to Ischemia-Reperfusion Induction.Adv Biomed Res 2019;8:64-64


How to cite this URL:
Lakzaei H, Safari T, Komeili GR. Interaction of Sex Hormones and the Renin–Angiotensin System in Ovariectomized Rats Subjected to Ischemia-Reperfusion Induction. Adv Biomed Res [serial online] 2019 [cited 2019 Nov 18 ];8:64-64
Available from: http://www.advbiores.net/article.asp?issn=2277-9175;year=2019;volume=8;issue=1;spage=64;epage=64;aulast=Lakzaei;type=0