Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 7  |  Issue : 1  |  Page : 82-

A 53 KDa Glycan Antigen of Hydatid Cyst Wall May Involve in Evasion from Host Immune System


Raheleh Rafiei Sefiddashti1, Seyedeh Maryam Sharafi2, Soltan Ahmad Ebrahimi3, Lame Akhlaghi1, Ali Moosavi4, Abasali Eskandarian5, Hossein Yousofi Darani5 
1 Department of Medical Parasitology and Mycology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Infectious Diseases and Tropical Medicine Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Pharmacology, Faculty of Medicine, Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
4 Department of Medical Parasitology and Mycology, Iran University of Medical Sciences, Tehran, Iran
5 Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Prof. Hossein Yousofi Darani
Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Recent studies have shown that similar host glycan antigens are expressed by helminths such as Echinococcus granulosus hydatid cysts to evade from host immune system. In this work to investigate these antigens further, immunological cross-reactivity between human sera and hydatid cyst wall antigens has been investigated. Materials and Methods: Hydatid cyst wall antigens were used in enzyme-linked immunosorbent assay and Western immunoblotting and probed with pooled sera of hydatidosis patients and healthy controls. Sodium metaperiodate treatment was used to investigate glycan antigens. Results: A band with molecular weight about 53 KDa reacted with both hydatid patients' sera and also normal human sera. It has been shown that this band was a glycan antigen. Conclusions: A 53 KDa glycan antigen of hydatid cyst wall that reacted with all human sera may have an important role for evasion from host immune system.


How to cite this article:
Sefiddashti RR, Sharafi SM, Ebrahimi SA, Akhlaghi L, Moosavi A, Eskandarian A, Darani HY. A 53 KDa Glycan Antigen of Hydatid Cyst Wall May Involve in Evasion from Host Immune System.Adv Biomed Res 2018;7:82-82


How to cite this URL:
Sefiddashti RR, Sharafi SM, Ebrahimi SA, Akhlaghi L, Moosavi A, Eskandarian A, Darani HY. A 53 KDa Glycan Antigen of Hydatid Cyst Wall May Involve in Evasion from Host Immune System. Adv Biomed Res [serial online] 2018 [cited 2019 Nov 17 ];7:82-82
Available from: http://www.advbiores.net/article.asp?issn=2277-9175;year=2018;volume=7;issue=1;spage=82;epage=82;aulast=Sefiddashti;type=0