Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 3  |  Issue : 1  |  Page : 261-

The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide


Shiva Seirafian, Yalda Haghdarsaheli, Mojgan Mortazavi, Mohsen Hosseini, Firouzeh Moeinzadeh 
 Department of Internal Medicine and Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Mojgan Mortazavi
Department of Internal Medicine and Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Background: The risk of cardiovascular disease in dialysis patients is higher than the general population. Vitamin D receptors exist in myocardium inhibit cardiac hypertrophy. N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a neurohormone secreted by the heart in response to ventricular mass increase. This study aimed to evaluate the effect of oral vitamin D on serum level of pro-B-type natriuretic peptide (pro-BNP) in peritoneal dialysis patients. Materials and Methods: In a randomized clinical trial, 84 peritoneal dialysis patients (49 males and 35 females) were randomly divided into two groups. The intervention group received 50000 units oral vitamin D per week, for 12 weeks if 25-hydroxy-vitamin D level was <10 ng/ml and for 8 weeks if it was between 10 ng/ml and 30 ng/ml. The control group received placebo. Parathyroid hormone, calcium, phosphor, 25-hydroxy-vitamin D, albumin and NT-pro-BNP were evaluated before and after the study. Results: The mean serum level of pro-BNP in patients receiving vitamin D and placebo group before the study was 875 pg/ml and 793 pg/ml, respectively. There was 895.9 pg/ml in the intervention group and 736.7 pg/ml in the control group (P = 0.7). Mean serum level of 25(OH) D in patients receiving oral vitamin D and placebo group before the study was 16.9 ng/ml and 31.9 ng/ml, respectively. There was 28.9 ng/ml in the intervention group and 12.9 ng/ml in the control group (P = 0.001). There were no significant differences regarding other indices (Alb, P, Ca, intact parathyroid hormone) between two groups. Conclusion: Vitamin D did not significantly change the serum level of pro-BNP in peritoneal dialysis patients.


How to cite this article:
Seirafian S, Haghdarsaheli Y, Mortazavi M, Hosseini M, Moeinzadeh F. The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide.Adv Biomed Res 2014;3:261-261


How to cite this URL:
Seirafian S, Haghdarsaheli Y, Mortazavi M, Hosseini M, Moeinzadeh F. The effect of oral vitamin D on serum level of N-terminal pro-B-type natriuretic peptide. Adv Biomed Res [serial online] 2014 [cited 2020 Sep 26 ];3:261-261
Available from: http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=261;epage=261;aulast=Seirafian;type=0