Occult Hepatitis B in Hemodialysis Patients is a Debate
Seyed Moayed Alavian
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
|Date of Web Publication||25-Jun-2018|
Prof. Seyed Moayed Alavian
Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Alavian SM. Occult Hepatitis B in Hemodialysis Patients is a Debate. Adv Biomed Res 2018;7:104
I read with interest the published article by Kalantari et al. in your journal recently. The authors presented the zero prevalence for occult hepatitis B virus (HBV) in patients on hemodialysis in Isfahan. However, I would like to highlight some points about occult HBV among them. Occult HBV patients may be seronegative (both hepatitis B core antibody [anti-HBcAb] and hepatitis B surface [anti-HBs] antibody are negative) or seropositive (anti-HBc is positive with or without anti-HBs positivity). Occult HBV is predominantly detected in patients with isolated anti-HBc (hepatitis B surface antigen [HBsAg] negative, anti-HBs negative and anti-HBc positive). Ramezani et al. showed that 1% of patients on hemodialysis with HBsAg-negative had occult HBV with positive HBV DNA in their serum without considering their HBcAb status. It seems that if the authors would done in all hemodialysis HBsAg-negative group, the result would be clearer and it seems that the occult HBV had underestimated in their study group. However, currently available evidence suggests a relatively high prevalence of occult hepatitis B in hemodialysis patients. Conventional serologic testing used in most hemodialysis centers is not able to identify the occult infection.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Kalantari H, Ferdowsi F, Yaran M. Prevalence of occult hepatitis B virus infection in hemodialysis patients in Isfahan, Iran. Adv Biomed Res 2016;5:151.
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Ramezani A, Aghasadeghi MR, Ahmadi F, Razeghi E, Eslamifar A, Banifazl M, et al.
Isolated anti-HBc and occult HBV infection in dialysis patients. Nephrourol Mon 2014;7:e22674.
Hollinger FB, Habibollahi P, Daneshmand A, Alavian SM. Occult hepatitis B infection in chronic hemodialysis patients: Current concepts and strategy. Hepat Mon 2010;10:199-204.