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Adv Biomed Res 2016,  5:46

The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies


1 Department of Medical Sciences, Islamic Azad University, Najafabad Branch, Tehran; Isfahan Neurosciences Research Center, Al Zahra Hospital, Tehran University of Medical Sciences, Tehran, Iran
2 PhD Candidate in Epidemiology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
3 Isfahan Neurosciences Research Center, Al Zahra Hospital, Tehran University of Medical Sciences, Tehran, Iran
4 Isfahan Neurosciences Research Center, Al Zahra Hospital, Tehran University of Medical Sciences, Tehran; Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran

Date of Submission08-Feb-2014
Date of Acceptance19-Aug-2014
Date of Web Publication16-Mar-2016

Correspondence Address:
Dr. Amir Pouya Tanhaei
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-9175.178791

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  Abstract 

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promised treatments for MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal, and neural stem cells have the potential to restore self-tolerance, provide in situ immunomodulation and neuroprotection, as well as promote regeneration. Thus, in this article, we will first provide an overview of the cell sources for proposed mechanisms that contribute to the beneficial effects of stem cell transplantation, the ideal route and/or timing of stem cell-based therapies for each main stem cell group, and finally, an overview of the current status of stem cell research in clinical trial stages in MS by comparable and healthy therapeutic effects of different stem cell therapies for MS patients.

Keywords: Cell therapy and transplantation, clinical trial, hematopoietic stem cells, mesenchymal stem cells, multiple sclerosis, neural stem/precursor cells, stem cells


How to cite this article:
Meamar R, Nematollahi S, Dehghani L, Mirmosayyeb O, Shayegannejad V, Basiri K, Tanhaei AP. The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies. Adv Biomed Res 2016;5:46

How to cite this URL:
Meamar R, Nematollahi S, Dehghani L, Mirmosayyeb O, Shayegannejad V, Basiri K, Tanhaei AP. The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies. Adv Biomed Res [serial online] 2016 [cited 2019 May 19];5:46. Available from: http://www.advbiores.net/text.asp?2016/5/1/46/178791



This article has been retracted at the request of the Editor-in-Chief, Editorial Board and Authors.





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