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REVIEW ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 1  |  Page : 187

From conventional therapy toward microRNA-based therapy in acute promyelocytic leukemia


Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Mohammadreza Sharifi
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81744-176
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-9175.190996

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Acute promyelocytic leukemia (APL) is a hematopoietic malignancy that is known with its special cytogenetic feature. Several studies have surveyed expression signature of microRNAs (miRNAs) in APL patients, especially patients who are treated with conventional therapy of this disease. Using miRNAs as diagnostic or prognostic biomarkers in various cancers has been widely studied. Currently, most studies are focusing on exploiting miRNAs as therapeutic tools, and promising progress has been achieved in this field. Recently, studies in the field of miRNA-based therapy in APL have been started.


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