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REVIEW ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 79

Leptin and its cardiovascular effects: Focus on angiogenesis


1 Department of Physiology and Pharmacology, Birjand University of Medical Sciences, Birjand, Iran
2 Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Majid Khazaei
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-9175.156526

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Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone homeostasis, and angiogenesis. The plasma concentration of leptin significantly increases in obese individuals. In the present review, we give an introduction concerning leptin, its receptors, signaling pathways, and its effect on cardiovascular system, especially on angiogenesis.


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