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BRIEF REPORT
Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 145

Serum inflammatory markers in obese mice: Effect of ghrelin


1 Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Birjand University of Medical Sciences, Birjand, Iran

Correspondence Address:
Dr. Majid Khazaei
Associate Professor of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2277-9175.161556

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Background: Ghrelin is involved in modulation of food intake and energy homeostasis; however, it may play a role in cardiovascular system and atherosclerosis process. This study aimed to investigate the effect of ghrelin on serum inflammatory markers in control and obese mice. Materials and Methods: Ghrelin (100 mg/kg/day, twice daily) was administered interaperitoneally to control and diet-induced obese mice. After 10 days, blood samples were taken. Results: Results showed that administration of ghrelin did not change serum hsCRP level; however, it reduced serum IL-6 concentration in obese mice (P < 0.05). Conclusion: It seems that the exact role and mechanism of ghrelin in prevention or treatment of atherosclerosis needs more studies.


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