Users Online: 987
Home Print this page Email this page
Home About us Editorial board Search Browse articles Submit article Ahead of Print Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2014  |  Volume : 3  |  Issue : 1  |  Page : 127

Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33) and asthma


1 Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Aquired Immunodeficiency Research Center, Infectious Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Cellular and Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Immunology, Faculty of Medicine; Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Mazdak Ganjalikhani Hakemi
Cellular and Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
Login to access the Email id

Source of Support: The research was funded by a grant (#188084) from the Isfahan University of Medical Sciences, Isfahan, Iran,, Conflict of Interest: None


DOI: 10.4103/2277-9175.133249

Rights and Permissions

Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-α and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3942    
    Printed60    
    Emailed0    
    PDF Downloaded1208    
    Comments [Add]    
    Cited by others 28    

Recommend this journal