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CASE REPORT
Year : 2013  |  Volume : 2  |  Issue : 1  |  Page : 6

An insight into genetics of non-syndromic cleft palate


1 Medical Genetics Laboratory, Alzahra University Hospital; Pediatric Inherited Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
3 Pediatric Surgery Department, Emam Hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4 Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Maryam Sedghi
Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: This work was funded by grant number 189087 from deputy for research, Isfahan University of Medical Sciences, Isfahan, Iran., Conflict of Interest: None


DOI: 10.4103/2277-9175.107969

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Our proband is a 29-year-old man, who is affected with soft cleft palate and hypernasality. A study of about six generations of this family pedigree shows that cleft palate has repeatedly occurred in males, with probably a X-linked recessive pattern of inheritance. Interestingly, the sister of the proband is affected with hypernasality and she has an affected son. This is the first report of X-linked inheritance pattern of cleft palate in Iran.


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